ARHGAP5 antibody

Principal name

ARHGAP5 antibody

Alternative names for ARHGAP5 antibody

RHOGAP5, p190-B, Rho GTPase-activating protein 5, Rho-type GTPase-activating protein 5

SwissProt ID

P97393 (Mouse), Q13017 (Human)

Gene ID

394 (ARHGAP5)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Flow Cytometry (F), Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of ARHGAP5 antibody

The p190 Rho GTPase activating protein RhoGAP) family includes two closely related proteins, p190-A and p190-B. p190-B contains an N-terminal GTPase domain and a C-terminal Rho-GAP domain (1). p190-B can be directly phosphorylated on a single identified tyrosine residue by the activated insulin and IGF-1 receptors. This phosphorylation causes p190-B to translocate to the lipid rafts of the plasma membrane, where it can facilitate the inactivation of the Rho GTPase. P190-B also has been shown to be tyrosine phosphorylated by c-Src and v-Src. Additionall; the GAP domain of p190-B as shown to attenuate signal-transducing activity of Rac, Rho and CDC42 (2-3).

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