ARHGDIB / D4-GDI antibody

Principal name

ARHGDIB / D4-GDI antibody

Alternative names for ARHGDIB / D4-GDI antibody

Rho GDI 2, GDIA2, GDID4, RAP1GN1, Rho-GDI beta, Ly-GDI, RhoGDI2, Rho GDP-dissociation inhibitor 2

SwissProt ID

P52566 (Human), Q61599 (Mouse), Q9TU03 (Bovin)

Gene ID

397 (ARHGDIB)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Paraffin Sections (P), Immunoprecipitation (IP), EPair for Elisa (EPair)

Background of ARHGDIB / D4-GDI antibody

D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kD mature form of D4-GDI to give a 23 kD and 5 kD size fragment. The 23 kD fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-terminal kinase, a regulator of apoptosis, may be one of the mechanisms.

General readings

1. Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N; EPICURO/Spanish Bladder Cancer Study i Genetic susceptibility to distinct bladder cancer subphenotypes.
European urology 2010 Feb 57 (2): 283-92.
PMID: 19692168

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ARHGDIB / D4-GDI antibody

Human tonsil stained with anti-D4GDI antibody Rabbit Purified Hu P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

ARHGDIB / D4-GDI antibody

Human tonsil stained with anti-D4GDI antibody Rabbit Purified Hu P, WB
1 ml / €440.00
  Acris Antibodies GmbH

ARHGDIB / D4-GDI antibody

Human tonsil stained with anti-D4GDI antibody Rabbit Purified Hu P, WB
0.1 ml / €180.00
  Acris Antibodies GmbH

ARHGDIB / D4-GDI (N-term) antibody

(0.1ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Por E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ARHGDIB / D4-GDI antibody

Western Blot: D4-GDI/RhoGDI2 Antibody (10D774) [TA336402] - Analysis of D4GDI in Jurkat cells using TA336402 at 2 ug/ml and D4-GDI (cleavage specific) at 0.1 ug/ml. Cells were treated with 2 uM staurosporine for different time periods. TA336402 detects bo Mouse IgG 10D774 Purified Hu F, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ARHGDIB / D4-GDI antibody

Western Blot: D4-GDI/RhoGDI2 (cleavage specific) Antibody (97A1015) [TA336465] - WB analysis: HL60 cells were treated for different time periods with 10 ng/ml of anti-Fas mAb (TA336465, Clone DX2). Harvested cells were lysed and resolved by SDS-PAGE and t Mouse IgG2b 97A1015 Purified Hu, Ms C, F, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ARHGDIB / D4-GDI antibody

Host: Rabbit; Target Name: ARHGDIB; Sample Tissue: 721_B Whole Cell lysates; Antibody Dilution: 1.0 ug/ml ARHGDIB is supported by BioGPS gene expression data to be expressed in 721_B Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

ARHGDIB / D4-GDI (full length) antibody

Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with ARHGDIB antibody AP22691PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Hu P
0.25 ml / €470.00
  Acris Antibodies GmbH

ARHGDIB / D4-GDI antibody

ARHGDIB / D4-GDI Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

ARHGDIB / D4-GDI antibody

ARHGDIB MaxPab polyclonal antibody. Western Blot analysis of ARHGDIB expression in human spleen. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

ARHGDIB / D4-GDI antibody

ARHGDIB MaxPab polyclonal antibody. Western Blot analysis of ARHGDIB expression in human spleen. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

ARHGDIB / D4-GDI antibody

Western Blot analysis of ARHGDIB expression in transfected 293T cell line (H00000397-T01) by ARHGDIB MaxPab polyclonal antibody.

Lane 1: ARHGDIB transfected lysate(23.00 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

ARHGDIB / D4-GDI antibody

Detection limit for recombinant GST tagged ARHGDIB is approximately 3ng/ml as a capture antibody. Mouse IgG1 2C12-B6 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

ARHGDIB / D4-GDI antibody

Western blot analysis of ARHGDIB in Jurkat cells using ARHGDIB monoclonal antibody, clone 10D774 ( Cat # MAB0058 ) at 2 µg/ml and ARHGDIB monoclonal antibody, clone 97A1015 ( Cat # MAB0059 ) at 0.1 µg/ml.
Cells were treated with 2 µM staurosporine for different time periods.
ARHGDIB monoclonal antibody, clone 10D774 ( Cat # MAB0058 ) detects both the full-length and cleaved forms of ARHGDIB while ARHGDIB monoclonal antibody, clone 97A1015 ( Cat # MAB0059 ) specifically detects only the cleaved form of the protein. Mouse IgG 10D774 Hu WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

ARHGDIB / D4-GDI antibody

Immunohistochemical analysis of ARHGDIB monoclonal antibody, clone 97A1015 ( Cat # MAB0059 ) in formalin-fixed, paraffin-embedded human breast tumor tissue using an isotype control ( top ) and ARHGDIB monoclonal antibody, clone 97A1015 ( Cat # MAB0059 ) ( bottom ) at 5 µg/ml. Mouse IgG2b 97A1015 Hu, Ms F, IP, P, WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

ARHGDIB / D4-GDI antibody

Intracellular flow cytometric analysis of cleaved ARHGDIB in 106 camptothecin-treated (red) and untreated (Green) HL-60 cells using 0.5 µg of ARHGDIB monoclonal antibody, clone 97A1015 (FITC) ( Cat # MAB0060 ). The shaded histogram represents cells without antibody. Mouse IgG2b 97A1015 Hu, Ms F
0.1 mg / €560.00
  Abnova Taiwan Corp.

ARHGDIB / D4-GDI antibody

Western blot analysis of ARHGDIB with Jurkat cell lysate. Rabbit Hu WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

ARHGDIB / D4-GDI antibody

Immunohistochemical staining of ARHGDIB on formalin fixed, paraffin embedded human tonsil with ARHGDIB polyclonal antibody. Rabbit Hu P, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

ARHGDIB / D4-GDI antibody

Western Blot: D4-GDI/RhoGDI2 Antibody (10D774) [NB100-55788] - Western blot analysis of NB100-55788 in whole Jurkat cell lysate. Mouse 10D774 Biotin Hu E
0.1 mg / €360.00
  Novus Biologicals Inc.

ARHGDIB / D4-GDI (cleaved) antibody

Flow Cytometry: cleaved D4-GDI/RhoGDI2  Antibody (97A1015) [FITC] [NB100-56060] - Intracellular flow cytometric analysis of cleaved D4-GDI in 10^6 camptothecin-treated (red) and untreated (green) HL60 cells using 0.5 ug of IMG-160C.  The shaded histogram represents cells without antibody. Mouse 97A1015 FITC Hu, Ms F
0.1 mg / €360.00
  Novus Biologicals Inc.

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