ARHGEF2 antibody

Principal name

ARHGEF2 antibody

Alternative names for ARHGEF2 antibody

KIAA0651, LFP40, GEF-H1, Rho guanine nucleotide exchange factor 2, Guanine nucleotide exchange factor H1, Microtubule-regulated Rho-GEF, Proliferating cell nucleolar antigen p40

SwissProt ID

B2DCZ9 (Pig), Q5FVC2 (Rat), Q60875 (Mouse), Q865S3 (Canfa), Q92974 (Human)

Gene ID

9181 (ARHGEF2), 16800 (Arhgef2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Por (Porcine), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Sheep, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C), Paraffin Sections (P)

Background of ARHGEF2 antibody

GEFH1 is an ~110 kDa protein belonging to the Dbl family of proto-oncogenes. GEF-H1 can activate the small GTPase RhoA, but not Rac1 or Cdc42. Rho family GTPases are central regulators of epithelial tight junctions and the cytoskeleton. GEF-H1 can associate with different cytoskeletal structures, namely microtubules and the actin cytoskeleton. It has also been proposed to mediate crosstalk between the two types of filaments.
Localization of GEF-H1 differs between cell types. In MRC-5 fibroblast cells, GEF-H1 localizes to stress fibers. In epithelial cells, GEF-H1 is associated with apical tight junctions and involved in regulating paracellular permeability of small hydrophilic tracers. Furthermore, its subcellular localization changes in mitotic cells, where endogenous GEF-H1 is concentrated at mitotic spindles. GEF-H1 is capable of binding to the F-actin binding junctional adaptor cingulin. Binding to cingulin inhibits GEF-H1 and results in the downregulation of RhoA and inhibition of G1/S phase transition. In low confluent cultured cells, the localization of GEF-H1 is predominantly cytoplasmic. With increasing density of the cells, free GEF-H1 is sequestered at the tight junctions by cingulin.
GEF-H1 is part of the signaling pathway connecting epithelial polarity with the cell cycle, and as such involved in oncogenesis.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ARHGEF2 antibody

Western blot analysis of extracts from RAW264.7 cells, using ARHGEF2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ARHGEF2 antibody

Western blot analysis of extracts of various cell lines, using ARHGEF2 antibody. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ARHGEF2 antibody

WB Suggested Anti-ARHGEF2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Human Placenta Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ARHGEF2 antibody

ARHGEF2 Mouse IgG1 B4/7 Purified Can, Hu, Ms C, ICC/IF, IP, WB
0.1 mg / €490.00
  Acris Antibodies GmbH

ARHGEF2 antibody

Western blot analysis using anti-Lfc antibody on HEK-293 cell transfected with vector alone (Lane 1), LFC-short (Lane 2) and LFC-long (Lane 3). Sheep IgG Purified Ms ICC/IF, IP, WB
0.25 mg / €360.00
  Acris Antibodies GmbH

ARHGEF2 antibody

Western blot (WB) analysis of ARHGEF2 antibody (Cat.-No.: AP20505PU-N) in extracts from NIH cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

ARHGEF2 antibody

ARHGEF2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

ARHGEF2 antibody

ARHGEF2 Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

ARHGEF2 antibody

Western blot analysis using Arhgef2 polyclonal antibody ( Cat # PAB10113 ) on HEK293 cell transfected with vector alone (lane 1), Arhgef2-short (lane 2) and Arhgef2-long (lane 3). Sheep IgG Purified Ms WB
50 µg / €400.00
  Abnova Taiwan Corp.

ARHGEF2 pSer885 antibody

Western blot analysis of extracts from HeLa cells treated with TSA 400nM 24H and Jurkat cells treated with forskolin 40nM 30', using Rho/Rac Guanine Nucleotide Exchange Factor 2 (Phospho-Ser885) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

ARHGEF2 pSer885 antibody

Western blot analysis of extracts from HeLa cells treated with TSA 400nM 24H and Jurkat cells treated with forskolin 40nM 30', using Rho/Rac Guanine Nucleotide Exchange Factor 2 (Phospho-Ser885) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

ARHGEF2 antibody

Western blot analysis of extracts from NIH-3T3 cells, using Rho/Rac Guanine Nucleotide Exchange Factor 2 (Ab-885) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

ARHGEF2 antibody

Western blot analysis of extracts from NIH-3T3 cells, using Rho/Rac Guanine Nucleotide Exchange Factor 2 (Ab-885) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

ARHGEF2 antibody

Western blot analysis of extracts from RAW264.7 cells, using ARHGEF2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Rt E, WB
50 µg / €205.00
  Assay Biotech

ARHGEF2 antibody

Western blot analysis of extracts from RAW264.7 cells, using ARHGEF2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

ARHGEF2 (C-term) antibody

Human Placenta; WB Suggested Anti-ARHGEF2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Human Placenta; ARHGEF2 antibody - C-terminal region (ARP59669_P050) in Human Placenta cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

ARHGEF2 antibody

Western blot analysis of GEF H1 expression in HeLa (A); NIH3T3 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

ARHGEF2 antibody

Western blot analysis of GEF H1 expression in HeLa (A); NIH3T3 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

ARHGEF2 antibody

Western blot analysis of GEF H1 expression in HeLa (A); NIH3T3 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

ARHGEF2 antibody

Western blot analysis of GEF H1 expression in Hela (A); Jurkat (B); NIH3T3 (C) whole cell lysates. Rabbit Aff - Purified Can, Hu, Ms, Por, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

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