ARHGEF7 antibody

Principal name

ARHGEF7 antibody

Alternative names for ARHGEF7 antibody

COOL1, KIAA0142, P85SPR, PAK3BP, PIXB, Nbla10314, Beta-Pix, COOL-1, p85, Rho guanine nucleotide exchange factor 7, PAK-interacting exchange factor beta

SwissProt ID

O55043 (Rat), Q14155 (Human), Q9ES28 (Mouse)

Gene ID

8874 (ARHGEF7), 54126 (Arhgef7), 114559

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection))

Background of ARHGEF7 antibody

Cool/Pix proteins comprise a family of guanine nucleotide exchange factors (GEFs) localized to focal adhesions. The family consists of two isoforms, cool2/apix and cool1/ßPix, the latter having two splice variants that vary in their carboxy termini. Cool1/ßPix, like other GEFs, has a DH (Dbl homology) domain, which allows binding of small GTPases and GDP/GTP exchange, and a PH (Pleckstrin homology) domain, which is important in regulating subcellular localization. Cool1/ßPix also has an SH3 domain, which binds to the PAK kise, a downstream effector of cdc42 and Rac. Phosphorylation of cool1/ßPix by PAK2 downstream of MAPK sigling alters the localization of a complex containing PAK2 and cool-1/ßPix, regulating formation of growth cones in response to growth factors. Growth factor induced activation of Rac1 via cool1/ßPix was later shown to occur independently of subcellular localization. Endothelin-1 stimulation of mesangial cells stimulates the protein kise A (PKA) pathway, resulting in translocation of cool-1/ßPix and activation of cdc42.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ARHGEF7 antibody

  Rabbit polyclonal anti-ARHGEF7 antibody  
Western blot analysis of extracts from rat muscle cells and rat heart cells, using ARHGEF7 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ARHGEF7 antibody

  ARHGEF7 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using ARHGEF7 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ARHGEF7 antibody

  Rabbit Polyclonal Anti-ARHGEF7 Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane 1-3: Human brain malignant glioma tissue, A172 cells, 293T cells, Primary antibody: (ARHGEF7 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ARHGEF7 antibody

Western blot analysis of extracts from rat muscle/rat heart cells, using ARHGEF7 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

ARHGEF7 antibody

Western blot analysis of extracts from rat muscle/rat heart cells, using ARHGEF7 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

ARHGEF7 - human gene knockout kit via CRISPR

ARHGEF7 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ARHGEF7 - human gene knockout kit via CRISPR

ARHGEF7 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ARHGEF7 - human gene knockout kit via CRISPR

ARHGEF7 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ARHGEF7 - human gene knockout kit via CRISPR

ARHGEF7 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Arhgef7 - mouse gene knockout kit via CRISPR

Arhgef7 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Arhgef7 - mouse gene knockout kit via CRISPR

Arhgef7 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Arhgef7 - mouse gene knockout kit via CRISPR

Arhgef7 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Arhgef7 - mouse gene knockout kit via CRISPR

Arhgef7 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ARHGEF7 (transcript variant 2)

  Recombinant protein of human Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 2  
ARHGEF7 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ARHGEF7 (transcript variant 5)

  Recombinant protein of human Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 5  
ARHGEF7 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

ARHGEF7 overexpression lysate

ARHGEF7 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ARHGEF7 (mGFP-tagged) - Human Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, ARHGEF7 (mGFP-tagged) - Human Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, ARHGEF7 (mGFP-tagged) - Human Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, ARHGEF7 (mGFP-tagged) - Human Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,700.00
  OriGene Technologies, Inc.

Lenti ORF particles, ARHGEF7 (mGFP-tagged)-Human Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, ARHGEF7 (mGFP-tagged)-Human Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, ARHGEF7 (mGFP-tagged)-Human Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, ARHGEF7 (mGFP-tagged)-Human Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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