ARHGEF7 antibody

Principal name

ARHGEF7 antibody

Alternative names for ARHGEF7 antibody

COOL1, KIAA0142, P85SPR, PAK3BP, PIXB, Nbla10314, Beta-Pix, COOL-1, p85, Rho guanine nucleotide exchange factor 7, PAK-interacting exchange factor beta

SwissProt ID

O55043 (Rat), Q14155 (Human), Q9ES28 (Mouse)

Gene ID

8874 (ARHGEF7), 4588745 (A1DB76)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Paraffin Sections (P)

Background of ARHGEF7 antibody

Cool/Pix proteins comprise a family of guanine nucleotide exchange factors (GEFs) localized to focal adhesions. The family consists of two isoforms, cool2/apix and cool1/ßPix, the latter having two splice variants that vary in their carboxy termini. Cool1/ßPix, like other GEFs, has a DH (Dbl homology) domain, which allows binding of small GTPases and GDP/GTP exchange, and a PH (Pleckstrin homology) domain, which is important in regulating subcellular localization. Cool1/ßPix also has an SH3 domain, which binds to the PAK kise, a downstream effector of cdc42 and Rac. Phosphorylation of cool1/ßPix by PAK2 downstream of MAPK sigling alters the localization of a complex containing PAK2 and cool-1/ßPix, regulating formation of growth cones in response to growth factors. Growth factor induced activation of Rac1 via cool1/ßPix was later shown to occur independently of subcellular localization. Endothelin-1 stimulation of mesangial cells stimulates the protein kise A (PKA) pathway, resulting in translocation of cool-1/ßPix and activation of cdc42.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ARHGEF7 antibody

Western blot analysis of extracts from rat muscle cells and rat heart cells, using ARHGEF7 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ARHGEF7 antibody

Western blot analysis of extracts of various cell lines, using ARHGEF7 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ARHGEF7 antibody

ARHGEF7 polyclonal antibody (A01), Lot # 051128JC01 Western Blot analysis of ARHGEF7 expression in U-2 OS ( Cat # L022V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

ARHGEF7 antibody

Western Blot analysis of ARHGEF7 expression in transfected 293T cell line (H00008874-T01) by ARHGEF7 MaxPab polyclonal antibody.

Lane 1: ARHGEF7 transfected lysate(73.10 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

ARHGEF7 antibody

Western blot analysis of extracts from rat muscle/rat heart cells, using ARHGEF7 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

ARHGEF7 antibody

Western blot analysis of extracts from rat muscle/rat heart cells, using ARHGEF7 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

ARHGEF7 antibody

ARHGEF7 Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

ARHGEF7 antibody

ARHGEF7 Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
50 µg / €290.00
  Novus Biologicals Inc.

ARHGEF7 antibody

Immunohistochemistry-Paraffin: ARHGEF7 Antibody [NBP1-88650] - Immunohistochemical staining of human duodenum shows cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ARHGEF7 (transcript variant 2)

ARHGEF7 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ARHGEF7 (transcript variant 5)

ARHGEF7 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ARHGEF7

ARHGEF7 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

ARHGEF7

ARHGEF7 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ARHGEF7 overexpression lysate

ARHGEF7 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

14 Item(s)

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