Arrestin beta-1 / ARRB1 antibody

Principal name

Arrestin beta-1 / ARRB1 antibody

Alternative names for Arrestin beta-1 / ARRB1 antibody

ARR1, Beta-arrestin-1

SwissProt ID

P17870 (Bovin), P29066 (Rat), P49407 (Human), Q8BWG8 (Mouse), Q95223 (Rabit)

Gene ID

408 (ARRB1), 25387 (Arrb1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Rb (Rabbit), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Immunoprecipitation (IP)

Background of Arrestin beta-1 / ARRB1 antibody

Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Arrestin beta-1 / ARRB1 antibody

Western blot analysis of extracts of various cell lines, using ARRB1 antibody. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Arrestin beta-1 / ARRB1 antibody

Western blot analysis of extracts from Jurkat cells and HUVEC cells, using ARRB1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Arrestin beta-1 / ARRB1 (C-term) antibody

ARRB1 Antibody (C-term) (Cat. #TA324455) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the ARRB1 antibody detected the ARRB1 protein (arrow). Rabbit Ig Aff - Purified Bov, Hu, Ms, Rb, Rt F, ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Arrestin beta-1 / ARRB1 antibody

Western blot detection of beta Arrestin 1 in PC12,Raw264.7,MCF7 and mouse brain cell lysates using beta Arrestin 1 mouse mAb (1:500 diluted).Predicted band size:50KDa.Observed band size:50KDa. Mouse 1H4-F5-C11 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Arrestin beta-1 / ARRB1 antibody

Immunohistochemistry (IHC) analyzes of Arrestin 1 antibody (Cat.-No.: AP06496PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Arrestin beta-1 / ARRB1 antibody

Western blot (WB) analysis of Arrestin-β-1 antibody (Cat.-No.: AP06791PU-N) at 1/500 dilution.Lane1: MCF-7 whole cell lysateLane2: Mouse brain tissue lysateLane3: H9C2 whole cell lysate Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Arrestin beta-1 / ARRB1 pSer412 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Arrestin 1 (Phospho-Ser412) antibody AP55695PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu P, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

Arrestin beta-1 / ARRB1 pSer412 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Arrestin 1 (Phospho-Ser412) antibody AP55695PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu P, WB
50 µl / €270.00
  Acris Antibodies GmbH

Arrestin beta-1 / ARRB1 antibody

Western Blot analysis of ARRB1 expression in transfected 293T cell line (H00000408-T02) by ARRB1 MaxPab polyclonal antibody.

Lane 1: ARRB1 transfected lysate(47.10 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Arrestin beta-1 / ARRB1 antibody

Arrestin beta-1 / ARRB1 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Arrestin beta-1 / ARRB1 antibody

Western Blot analysis of ARRB1 expression in transfected 293T cell line (H00000408-T02) by ARRB1 MaxPab polyclonal antibody.

Lane 1: ARRB1 transfected lysate(47.10 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Arrestin beta-1 / ARRB1 pSer412 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Arrestin 1 (Phospho-Ser412) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P, WB
50 µg / €205.00
  Assay Biotech

Arrestin beta-1 / ARRB1 pSer412 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Arrestin 1 (Phospho-Ser412) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P, WB
0.1 mg / €310.00
  Assay Biotech

Arrestin beta-1 / ARRB1 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Arrestin 1 (Ab-412) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

Arrestin beta-1 / ARRB1 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Arrestin 1 (Ab-412) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

Arrestin beta-1 / ARRB1 antibody

Western blot analysis of extracts from Jurkat/HuvEc cells, using ARRB1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

Arrestin beta-1 / ARRB1 antibody

Western blot analysis of extracts from Jurkat/HuvEc cells, using ARRB1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

Arrestin beta-1 / ARRB1 (Center) antibody

Human THP-1; WB Suggested Anti-ARRB1 Antibody Titration: 0.2-1 ug/ml. Positive Control: THP-1 cell lysate; ARRB1 antibody - middle region (ARP30523_P050) in Human THP-1 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Arrestin beta-1 / ARRB1 pSer412 antibody

Immunohistochemical analysis of Beta-arrestin-1 (pS412) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
30 µl / €210.00
  Cohesion Biosciences Ltd.

Arrestin beta-1 / ARRB1 pSer412 antibody

Immunohistochemical analysis of Beta-arrestin-1 (pS412) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €330.00
  Cohesion Biosciences Ltd.

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