Arrestin beta-2 / ARRB2 antibody

Principal name

Arrestin beta-2 / ARRB2 antibody

Alternative names for Arrestin beta-2 / ARRB2 antibody

Beta-arrestin-2, ARB2, ARR2

SwissProt ID

P29067 (Rat), P32120 (Bovin), P32121 (Human), Q91YI4 (Mouse)

Gene ID

409 (ARRB2), 25388 (Arrb2)

Available reactivities

Hu (Human), Rt (Rat), Bov (Bovine), Ms (Mouse), Can (Canine), Chk (Chicken), Por (Porcine), Rb (Rabbit), Ze (Zebrafish), African clawed frog, Xen (Xenopus), Eq (Equine), Prim (Primate)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Immunoprecipitation (IP), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of Arrestin beta-2 / ARRB2 antibody

Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to and interpreted by the brain. The process of converting light to an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active. In the active state, rhodopsin activates transducin, a GTP binding protein. Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentrations causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin's activity is believed to be shut off by its phosphorylation followed by binding of the soluble protein arrestin.
Arrestins are cytosolic proteins that are involved in G protein-coupled receptor (GPCR) desensitization. Arrestin binding to activated GPCRs is phosphorylation dependent and, once bound, uncouple the GPCR from the associated heterotrimeric G proteins. There are currently 4 known mammalian isoforms, beta-arrestin1 (arrestin2), beta-arrestin2 (arrestin3), visual arrestin (arrestin1), and cone arrestin. The beta- isoforms are ubiquitously expressed and are known to interact with acetylcholine and adrenergic receptors. Visual and cone arrestins are found to interact directly with transducin.

General readings

Mundell SJ et al. Characterization of arrestin expression and function. Methods Enzymol 343:600-11 (2002). PubMed PMID: 11665594
McDonald PH & Lefkowitz RJ Beta-Arrestins: new roles in regulating heptahelical receptors' functions. Cell Signal 13:683-9 (2001). PubMed PMID: 11602178
Penn RB et al. Arrestin specificity for G protein-coupled receptors in human airway smooth muscle. J Biol Chem 276:32648-56 (2001). PubMed PMID: 11418617

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Arrestin beta-2 / ARRB2 antibody

TA303022 (0.03µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt E, IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Arrestin beta-2 / ARRB2 antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 3G1 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Arrestin beta-2 / ARRB2 antibody

Immunoperoxidase of monoclonal antibody to ARRB2 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 3ug/ml] Mouse IgG2a 3G1 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Arrestin beta-2 / ARRB2 antibody

Western Blot: Arrestin beta 2 Antibody [TA337007] - analysis of ARRB2 in HUVEC cell lysate in the 1) absence and 2) presence of immunizing peptide using ARRB2 antibody at 0.25 ug/ml. I goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate Rabbit Purified Bov, Can, Eq, Hu, Ms, Prim, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Arrestin beta-2 / ARRB2 antibody

Immunofluorescence of monoclonal antibody to ARRB2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG2a 4D2 Purified Hu, Rt E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Arrestin beta-2 / ARRB2 antibody

ARRB2 polyclonal antibody ( Cat # PAB6785 ) ( 0.03 µg/ml ) staining of human spleen lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu, Ms, Rt E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Arrestin beta-2 / ARRB2 antibody

Human Skin; ARRB2 antibody - middle region (ARP48007_P050) in Human Skin cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

Arrestin beta-2 / ARRB2 antibody

Arrestin beta-2 / ARRB2 Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

Arrestin beta-2 / ARRB2 antibody

Western Blot: Arrestin beta 2 Antibody [NB100-1515]-(0.3µg/ml) staining of Human Brain lysate (35µg protein in RIPA buffer). Goat Aff - Purified Hu, Ms, Rt E, IP, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Arrestin beta-2 / ARRB2 antibody

Western Blot: Arrestin Antibody [NB300-587] - Figure 1 shows a Western blot of pan Arrestin in rat retina using NB300-587. Rabbit Aff - Purified Bov, Rt IP, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Arrestin beta-2 / ARRB2 antibody

Western Blot: Arrestin beta 2 Antibody [NBP1-79278] - HepG2 cell lysate probed with NBP1-79278 (1ug/ml), run on 12% gel. Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Por, Rb, Rt, Xen, Ze P, WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Arrestin beta-2 / ARRB2

Arrestin beta-2 / ARRB2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Arrestin beta-2 / ARRB2

Arrestin beta-2 / ARRB2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Arrestin beta-2 / ARRB2

Arrestin beta-2 / ARRB2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Arrestin beta-2 / ARRB2

Arrestin beta-2 / ARRB2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

ARRB2 overexpression lysate

ARRB2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

ARRB2 overexpression lysate

ARRB2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Arrestin beta-2 / ARRB2 Lysate (Non-Denatured)

Arrestin beta-2 / ARRB2 Lysate (Non-Denatured)  
0.1 mg / €270.00
  Abnova Taiwan Corp.

18 Item(s)

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