Artemin antibody

Principal name

Artemin antibody

Alternative names for Artemin antibody

Enovin, Neublastin, ARTN, EVN

SwissProt ID

Q5T4W7 (Human), Q6AYE8 (Rat), Q9Z0L2 (Mouse)

Gene ID

11876 (Artn), 9048 (ARTN), 362572

Available reactivities

Ms (Mouse), Hu (Human), Mky (Monkey), Prim (Primate), Rt (Rat)

Available hosts

Goat, Rabbit, Mouse, Rat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Artemin antibody

Artemin is a member of the Glia Cel-lDerived Neurotrophic factor (GDNF) family ligands, which include GDNF, Persephin, Artemin, and Neurturin. GDNF family ligands are distant members of the Transforming Growth Factor β (TGFβ) superfamily. Similar to other TGFβ family proteins, Artemin is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxyterminal domain. The carboxy terminal domain of Artemin contains the characteristic seven conserved cysteine residues necessary for the formation of the cysteine-knot and the single interchain disulfide bond. Biologically active Artemin is a disulfide-linked homodimer of the carboxyterminal 113 amino acid residues. Mature mouse Artemin shares 88.5% amino acid sequence similarity with human Artemin. Mature Artemin also shares approximately 40% amino acid sequence identity with the other three members of the GDNF family ligands. Bioactivities of all GDNF family ligands are mediated through a receptor complex composed of a high affinity ligand binding component (GFRα1GFRα4) and a common signaling component, cRET (receptor tyrosine kinase). Artemin prefers to bind to GFRα3 and activites the GFRα3RET. However, in the presence of RET, it can bind to GFRα1 as well. Artemin has been shown to promote the survival and growth of various peripheral and central neurons, including sympathetic and dopaminergic neurons. It may also play an important role in the development of sympathetic neurons and several organs.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Artemin antibody

  Rabbit Polyclonal Artemin Antibody  
Western Blot: Artemin Antibody - Western Blot analysis of Artemin in human dorsal root ganglia, using anti-Artemin. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Artemin antibody

  Goat Anti-ARTN Antibody  
(0.1ug/ml) staining of HEK293 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Artemin antibody

  Rabbit Polyclonal Anti-ARTN Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane 1-2: A431 cells, 231 cells, Primary antibody: (ARTN Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Artemin antibody

  Rabbit Polyclonal Anti-ARTN Antibody  
Gel: 12%SDS-PAGE, Lysate: 50 ug, Lane 1-3: 293T cells, SP20 cells, human fetal liver tissue, Primary antibody: (ARTN Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Artemin antibody

Immunofluorescence analysis of GFRA3-Ret51 receptor complex bound Artemin.  Human U2OS cells were transfected with GFRa3-Ret51 expression vector followed by treatment with 100 nM Artemin. Artemin bound to the GFRa3-Ret51 receptor complex was detected by anti-Artemin antibody clone 2A5. Goat anti-mouse Dylight 488 conjugated antibody (dilution 1:1000) was used as secondary antibody. For nuclear staining DAPI was used. ArrayScan VTI platform (Thermo Scientific) was used for image acquisition (10x objective). Composite picture was generated using pseudocolors green for Artemin and blue for nuclei. A. Artemin bound to the GFRa3-Ret51 receptor complex; B. Negative control - GFRa3-Ret51 receptor expressing U2OS cells Mouse IgG1 2A5 Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

Artemin antibody

Immunofluorescence analysis of GFRA3-Ret51 receptor complex bound Artemin.  Human U2OS cells were transfected with GFRa3-Ret51 expression vector followed by treatment with 100 nM Artemin. Artemin bound to the GFRa3-Ret51 receptor complex was detected by anti-Artemin antibody clone 2D12. Goat anti-mouse Dylight 488 conjugated antibody (dilution 1:1000) was used as secondary antibody. For nuclear staining DAPI was used. ArrayScan VTI platform (Thermo Scientific) was used for image acquisition (10x objective). Composite picture was generated using pseudocolors green for Artemin and blue for nuclei. A. Artemin bound to the GFRa3-Ret51 receptor complex; B. Negative control - GFRa3-Ret51 receptor expressing U2OS cells. Mouse IgG1 2D12 Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

Artemin antibody

Immunofluorescence analysis of GFRA3-Ret51 receptor complex bound Artemin.  Human U2OS cells were transfected with GFRa3-Ret51 expression vector followed by treatment with 100 nM Artemin. Artemin bound to the GFRa3-Ret51 receptor complex was detected by anti-Artemin antibody clone 1F3. Goat anti-mouse Dylight 488 conjugated antibody (dilution 1:1000) was used as secondary antibody. For nuclear staining DAPI was used. ArrayScan VTI platform (Thermo Scientific) was used for image acquisition (10x objective). Composite picture was generated using pseudocolors green for Artemin and blue for nuclei. A. Artemin bound to the GFRa3-Ret51 receptor complex; B. Negative control - GFRa3-Ret51 receptor expressing U2OS cells. Mouse IgG1 1F3 Aff - Purified Hu E, ICC/IF
0.1 mg / €400.00
  Acris Antibodies GmbH

Artemin antibody

Immunofluorescence analysis of GFRA3-Ret51 receptor complex bound Artemin.  Human U2OS cells were transfected with GFRa3-Ret51 expression vector followed by treatment with 100 nM Artemin. Artemin bound to the GFRa3-Ret51 receptor complex was detected by anti-Artemin antibody clone 2G7. Goat anti-mouse Dylight 488 conjugated antibody (dilution 1:1000) was used as secondary antibody. For nuclear staining DAPI was used. ArrayScan VTI platform (Thermo Scientific) was used for image acquisition (10x objective). Composite picture was generated using pseudocolors green for Artemin and blue for nuclei. A. Artemin bound to the GFRa3-Ret51 receptor complex; B. Negative control - GFRa3-Ret51 receptor expressing U2OS cells Mouse IgG1 2G7 Aff - Purified Hu E, ICC/IF
0.1 mg / €400.00
  Acris Antibodies GmbH

Artemin antibody

Artemin Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

Artemin antibody

Artemin Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

Artemin antibody

Artemin Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

Artemin antibody

Artemin Rabbit Aff - Purified Hu E, WB
50 µg / €220.00
  Acris Antibodies GmbH

Artemin (127-140) antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Mky, Prim P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Artemin antibody

Artemin Rat IgG2 6G32 Purified Ms C, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

Artemin antibody

Artemin Goat Purified Ms C, E, WB
0.1 mg / €450.00
  Neuromics Antibodies

Artemin antibody

Artemin Mouse IgG 185230 Purified Ms C, E, WB
0.5 mg / €410.00
  Neuromics Antibodies

Artemin antibody

Artemin Rabbit Purified Hu WB
0.1 ml / €330.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

ARTN - human gene knockout kit via CRISPR

ARTN - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ARTN - human gene knockout kit via CRISPR

ARTN - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ARTN - human gene knockout kit via CRISPR

ARTN - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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