Artemis antibody
Principal name
Artemis antibody
Alternative names for Artemis antibody
DCLRE1C, ASCID, SCIDA, SNM1C, SNM1-like protein, A-SCID protein, DNA cross-link repair 1C protein
Ncbi ID
NP_001029027.1, 9606, NP_001029029, NP_001029027, AAH22254, NM_022487, NM_001033855, NP_001103684.1, NM_146114, NM_147145, NM_001033858, NM_001033857
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)
Background of Artemis antibody
Artemis is a widely expressed 78 kD protein involved in non-homologous end joining. This protein has been reported to be involved in DNA double-strand break repair and the processing of hairpin coding ends during VDJ recombination. Artemis has endonuclease and exonuclease activity and has been shown to be mutated in human severe combined immune deficiency disorder (T-B- radiosensitive SCID). Artemis is phosphorylated by DNA-PKcs; phosphorylation regulates intrinsic endonuclease and exonuclease activity. Artemis has been shown to form a complex with DNA-PKcs.
Structure: Protein involved in non-homologous end joining, predicted molecular weight approximately 78 kD.
Distribution: Widely expressed.
Function: Involved in DNA double-strand break repair and the processing of hairpin coding ends during VDJ recombination. Has endonuclease and exonuclease activity. Mutated in human severe combined immune deficiency disorder (T-B- radiosensitive SCID).
Interaction: Forms a complex with DNA-PKcs.
General readings
1. Pannicke U, Ma Y, Hopfner KP, Niewolik D, Lieber MR, Schwarz K. (2004) Functional and biochemical dissection of the structure-specific nuclease ARTEMIS. EMBO J.;23(9):1987-97.
2. Kobayashi,N. et al. (2003) Novel Artemis gene mutations of radiosensitive severe combined immunodeficiency in Japanese families. Hum.Genet. 112 (4), 348-352.
3. Noordzij,J.G. et al. (2003) Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-Bcell receptor checkpoint in bone marrow. Blood 101 (4), 1446-1452.
4. Moshous,D. et al. (2003) Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis.
J. Clin. Invest. 111 (3), 381-387.
5. Rooney, S. et al. (2003) Defective DNA Repair and Increased Genomic Instability in Artemis-deficient Murine Cells. J. Exp. Med. 197;5: 553-565.
6. Hous D, Callebaut I, de Chasseval R, Corneo B, Cavazzana-Calvo M, Le Deist F, Tezcan I, Sanal O, Bertrand Y, Philippe N, Fischer A, De Villartay JP: (2001) Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell 105(2): 177-186.















Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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TA309620 | Artemis antibody |
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Rabbit Polyclonal Artemis Antibody | |||||||
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Rabbit | Purified | Hu | WB |
0.1 mg /
€334.00
|
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OriGene Technologies, Inc. | |||||||
TA319208 | Artemis antibody |
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Goat polyclonal anti-Artemis antibody | |||||||
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Goat | Aff - Purified | Hu | E, P, WB |
0.1 mg /
€503.00
|
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OriGene Technologies, Inc. | |||||||
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TA332790 | Artemis antibody |
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Rabbit anti-DCLRE1C Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | ICC/IF, WB |
0.1 mg /
€335.00
|
|
OriGene Technologies, Inc. | |||||||
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TA339872 | Artemis antibody |
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Rabbit Polyclonal Anti-DCLRE1C Antibody | |||||||
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Rabbit | IgG | Purified | Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze | WB |
50 µg /
€360.00
|
|
OriGene Technologies, Inc. | |||||||
TA339873 | Artemis antibody |
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Rabbit Polyclonal Anti-DCLRE1C Antibody | |||||||
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Rabbit | IgG | Purified | Bov, Can, Eq, GP, Hu, Ms, Rb, Rt | WB |
50 µg /
€360.00
|
|
OriGene Technologies, Inc. | |||||||
AP07832PU-N | Artemis antibody |
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Goat | Aff - Purified | Hu | E, P, WB |
50 µg /
€380.00
|
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Acris Antibodies GmbH | |||||||
AP33127PU-N | Artemis antibody |
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Rabbit | IgG | Aff - Purified | Hu | ICC/IF, WB |
0.2 ml /
€360.00
|
|
Acris Antibodies GmbH | |||||||
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AP51199PU-N | Artemis (N-term) antibody |
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Rabbit | Ig | Aff - Purified | Hu, Ms | P, WB |
0.4 ml /
€370.00
|
|
Acris Antibodies GmbH | |||||||
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A0456-1 | Artemis pSer516 antibody |
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Rabbit | Aff - Purified | Hu, Ms | E, P, WB |
50 µg /
€230.00
|
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Assay Biotech | |||||||
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A0456-2 | Artemis pSer516 antibody |
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Rabbit | Aff - Purified | Hu, Ms | E, P, WB |
0.1 mg /
€330.00
|
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Assay Biotech | |||||||
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B0456-1 | Artemis antibody |
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Rabbit | Aff - Purified | Hu | E, ICC/IF, P |
50 µg /
€230.00
|
||
Assay Biotech | |||||||
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B0456-2 | Artemis antibody |
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Rabbit | Aff - Purified | Hu | E, ICC/IF, P |
0.1 mg /
€330.00
|
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Assay Biotech | |||||||
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CRISPR
Catalog No. | Species | Donor Vector | |
---|---|---|---|
KN203407 | DCLRE1C - human gene knockout kit via CRISPR |
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Human | GFP-Puro |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN203407BN | DCLRE1C - human gene knockout kit via CRISPR |
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Human | mBFP-Neo |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN203407LP | DCLRE1C - human gene knockout kit via CRISPR |
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Human | Luciferase-Puro |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN203407RB | DCLRE1C - human gene knockout kit via CRISPR |
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Human | RFP-BSD |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN304328 | Dclre1c - mouse gene knockout kit via CRISPR |
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Mouse | GFP-Puro |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN304328BN | Dclre1c - mouse gene knockout kit via CRISPR |
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Mouse | mBFP-Neo |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. | |||
KN304328LP | Dclre1c - mouse gene knockout kit via CRISPR |
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Mouse | Luciferase-Puro |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. |
Lysates
Catalog No. | ||
---|---|---|
LY402945 | DCLRE1C overexpression lysate |
|
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0.1 mg /
€295.00
|
|
OriGene Technologies, Inc. |