ASAP2 / DDEF2 antibody

Principal name

ASAP2 / DDEF2 antibody

Alternative names for ASAP2 / DDEF2 antibody

PAG3, PAP, KIAA0400, Arf-GAP with SH3 domain ANK repeat and PH domain-containing protein 2, Development and differentiation-enhancing factor 2, Paxillin-associated protein with ARF GAP activity 3, Pyk2 C-terminus-associated protein

SwissProt ID

O43150 (Human), Q7SIG6 (Mouse)

Gene ID

8853 (ASAP2), 211914 (Asap2)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Eq (Equine), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection))

Background of ASAP2 / DDEF2 antibody

This gene encodes a multidomain protein containing an N-termil alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-termil Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kise 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-termil proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport.

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