ASGR1 antibody

Principal name

ASGR1 antibody

Alternative names for ASGR1 antibody

ASGP-R 1, ASGPR 1, Asialoglycoprotein receptor 1, Hepatic lectin H1

SwissProt ID

P02706 (Rat), P07306 (Human), P34927 (Mouse)

Gene ID

432 (ASGR1), 24210 (Asgr1), 11889

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Frozen Sections (C)

Background of ASGR1 antibody

The asialoglycoprotein (ASGP) receptor is a transmembrane hepatocellular surface carbohydrate binding glycoproteins lacking terminal sialic acid residues (asialoglycoproteins). Characterization of the ASGP receptor  revealed its functional role in the binding, internalization and transport of a wide range of glycoproteins, which have exposed galactose or N-acetylgalactosamine residues, via the process of receptor-mediated endocytosis (RME). The ASGP receptor can bind a variety of important plasma proteins including transport proteins (i.e. transferrin), enzymes such as alkaline phosphatase, immunoglobulins including IgA, apoptotic hepatocytes, fibronectin and platelets. Additionally, the expression of the ASGP receptor has been clinically correlated to the level of hepatic function that is lost during liver diseases related to cancer, viral hepatitis, and cirrhosis. The ASGP receptor consists of major and minor subunits, which in the rat were identified as rat hepatic lectin (RHL) 1 and RHL 2/3, with molecular weights of respectively 42, 49 and 54 kDa. The selective binding (calcium and pH depended) and uptake of terminal galactosyl bearing proteins requires the formation of hetero-oligomers between these major and minor forms The total ASGP receptor population consisted of two functionally distinct receptor populations, designated State 1 and State 2, which were involved in the endocytosis and intracellular processing of ligands by different pathways.

General readings

Yik,J.H. et al., (2002) J. Biol. Chem. 277 (49), 47305-47312

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ASGR1 antibody

  Rabbit Polyclonal Anti-ASGR1 Antibody  
WB Suggested Anti-ASGR1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Liver Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ASGR1 antibody

  Rabbit Polyclonal Anti-ASGR1 Antibody  
WB Suggested Antibody Titration: 0.2-1 ug/ml; Positive Control: Liver Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Por, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ASGR1 antibody

ASGR1 Mouse IgG1 8D7 FITC Hu, Rt C, E, ICC/IF, WB
0.1 mg / €530.00
  Acris Antibodies GmbH

ASGR1 antibody

ASGR1 Mouse IgG1 8D7 Purified Hu, Rt C, E, ICC/IF, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

ASGR1 (N-term) antibody

ASGR1 Antibody (N-term) (Cat. #AP50272PU-N) western blot analysis in MDA-MB231 cell line lysates (35µg/lane).This demonstrates the ASGR1 antibody detected the ASGR1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

ASGR1 - human gene knockout kit via CRISPR

ASGR1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ASGR1 - human gene knockout kit via CRISPR

ASGR1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ASGR1 - human gene knockout kit via CRISPR

ASGR1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ASGR1 - human gene knockout kit via CRISPR

ASGR1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Asgr1 - mouse gene knockout kit via CRISPR

Asgr1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Asgr1 - mouse gene knockout kit via CRISPR

Asgr1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Asgr1 - mouse gene knockout kit via CRISPR

Asgr1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Asgr1 - mouse gene knockout kit via CRISPR

Asgr1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ASGR1

  Recombinant protein of human asialoglycoprotein receptor 1 (ASGR1)  
ASGR1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

ASGR1 (full length, C-term flag tag)

  Recombinant protein of human desmin(DES),full length,with C-terminal flag tag, expressed in sf9 cells  
ASGR1 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
SF9 cells
20 µg / €399.00
  OriGene Technologies, Inc.

ASGR1 (transcript variant 1)

  Purified recombinant protein of Human asialoglycoprotein receptor 1 (ASGR1), transcript variant 1  
ASGR1 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

ASGR1 overexpression lysate

ASGR1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Asgr1 (GFP-tagged) - Mouse asialoglycoprotein receptor 1 (Asgr1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Asgr1 (GFP-tagged) - Mouse asialoglycoprotein receptor 1 (Asgr1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Asgr1 (Myc-DDK-tagged) - Mouse asialoglycoprotein receptor 1 (Asgr1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Asgr1 (Myc-DDK-tagged) - Mouse asialoglycoprotein receptor 1 (Asgr1), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Asgr1 (GFP-tagged ORF) - Rat asialoglycoprotein receptor 1 (Asgr1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Asgr1 (GFP-tagged ORF) - Rat asialoglycoprotein receptor 1 (Asgr1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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