ASIC1 / ACCN2 antibody

Principal name

ASIC1 / ACCN2 antibody

Alternative names for ASIC1 / ACCN2 antibody

BNAC2, Amiloride-sensitive cation channel 2 neuronal, Acid-sensing ion channel 1, Brain sodium channel 2

SwissProt ID

P55926 (Rat), P78348 (Human), Q1XA76 (Chick), Q6NXK8 (Mouse)

Gene ID

79123 (Accn2), 41 (ASIC1), 11419

Available reactivities

Rt (Rat), Hu (Human), Chk (Chicken), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Por (Porcine)

Available hosts

Guinea Pig, Rabbit, Sheep, Mouse, Goat

Available applications

Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of ASIC1 / ACCN2 antibody

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. FUNCTION: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Localizes in synaptosomes at dendritic synapses of neurons. TISSUE SPECIFICITY: Expressed in dorsal root ganglia (DRG) and sciatic nerve (at protein level). Widely distributed throughout the brain. Expressed in olfactory bulb, neo and allocortical regions, dentate granule cells, pyramidal cells of CA1-CA3 subfields of the hippocampal formation, habenula, basolateral amygdaloid nuclei, and in the Purkinje and granule cells of the cerebellum. Diffusely detected over most other regions of the basal ganglia, including thalamic nuclei, substantia nigra, striatum and globus pallidus, hypothalamus, midbrain, pons, medulla and choroid plexus. Isoform 3 is expressed only in dorsal root ganglion while isoform 1 is expressed in DRG, spinal chord, trigeminal ganglia and the trigeminal mesencephalic nucleus.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ASIC1 / ACCN2 antibody

Host: Rabbit; Target Name: ACCN2; Sample Tissue: Human Adult Placenta; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ASIC1 / ACCN2 antibody

Hum. Fetal Heart; Host: Rabbit. Target Name: ACCN2. Sample Tissue: Human Fetal Heart. Antibody Dilution: 1.0ug/ml.; ACCN2 antibody - N-terminal region (ARP35298_P050) in Hum. Fetal Heart cells using Western Blot Rabbit Aff - Purified Chk, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

ASIC1 / ACCN2 (460-526, Cytopl. Dom.) antibody

WB of rat brain lysate showing detection of ~60 kDa ASIC1 protein using Anti-ASIC1.  Lane 1: MW ladder. Lane 2: Anti-ASIC1 (1:100). Lane 3: Anti-ASIC1 (1:250). Lane 4: Anti-ASIC1 (1:500). Lane 5: Anti-ASIC1 (1:1000).  Load: 20 µg RB lysate per lane. Block: 5% milk + TBST 1hr at RT. Primary antibody: Mouse Anti-ASIC1 monoclonal antibody incubated for 60 min at RT. Secondary antibody: Goat Anti-Mouse HRP antibody at 1:50 for 60 min at RT. Colour Development: TMB solution for 30 min at RT. Mouse IgG1 S271-44 Purified Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ASIC1 / ACCN2 antibody

Western blot analysis of rat brain membranes: 1. Anti-ASIC1 antibody , (1:200). 2. Anti-ASIC1 antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

ASIC1 / ACCN2 antibody

TA348936 (0.3 ug/ml) staining of Mouse fetal Brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Purified Bov, Can, Ms, Por, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ASIC1 / ACCN2 antibody

Immunoblot versus whole brain lysates from adult WT, ASIC1 KO and ASIC2 KO mice probed with N271/44 (left) and N52A/42 (right) TC supe. Mouse brain samples courtesy of Julie Saugstad (Robert S. Dow Neurobiology Laboratories, Legacy Research Institute). Mouse IgG1 N271/44 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

ASIC1 / ACCN2 antibody

Immunoblot versus whole brain lysates from adult WT, ASIC1 KO and ASIC2 KO mice probed with N271/44 (left) and N52A/42 (right) TC supe. Mouse brain samples courtesy of Julie Saugstad (Robert S. Dow Neurobiology Laboratories, Legacy Research Institute). Mouse IgG1 N271/44 Purified Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

ASIC1 / ACCN2 (C-term) antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with ACCN2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ASIC1 / ACCN2 (N-term) antibody

Mouse Heart; WB Suggested Anti-Accn2 Antibody. . Titration: 1.0 ug/ml. . Positive Control: Mouse Heart; Accn2 antibody - N-terminal region (ARP35035_P050) in Mouse Heart cells using Western Blot Rabbit Aff - Purified Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

ASIC1 / ACCN2 antibody

Western blot analysis of ASIC1 expression in 293T (A); mouse brain (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

ASIC1 / ACCN2 antibody

Western blot analysis of ASIC1 expression in 293T (A); mouse brain (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

ASIC1 / ACCN2 antibody

Western blot analysis of ASIC1 expression in 293T (A); mouse brain (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

ASIC1 / ACCN2 antibody

ASIC1 / ACCN2 Guinea Pig Serum Rt C
50 µl / €210.00
  Neuromics Antibodies

ASIC1 / ACCN2 antibody

ASIC1 / ACCN2 Guinea Pig Serum Rt C

Regular Price: 0.15 ml / €390.00

Special Price: 0.15 ml / €301.00

  Neuromics Antibodies

ASIC1 / ACCN2 control peptide

ASIC1 / ACCN2
20 µg / €150.00
  Neuromics Antibodies

ASIC1 / ACCN2 antibody

ASIC1 / ACCN2 Rabbit Serum Hu, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

ASIC1 / ACCN2 antibody

ASIC1 / ACCN2 Guinea Pig Purified Rt P
50 µl / €310.00
  Novus Biologicals Inc.

ASIC1 / ACCN2 antibody

ASIC1 / ACCN2 Sheep Purified Hu, Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ASIC1 / ACCN2 (transcript variant 2)

ASIC1 / ACCN2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ASIC1 / ACCN2

ASIC1 / ACCN2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

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