ASIC2 / ACCN1 antibody

Principal name

ASIC2 / ACCN1 antibody

Alternative names for ASIC2 / ACCN1 antibody

BNAC1, MDEG, Brain sodium channel 1, Amiloride-sensitive cation channel 1, neuronal, Amiloride-sensitive brain sodium channel, Amiloride-sensitive cation channel neuronal 1, Acid-sensing ion channel 2

SwissProt ID

Q16515 (Human)

Gene ID

40 (ASIC2)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Eq (Equine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P)

Background of ASIC2 / ACCN1 antibody

ASIC2a is a member of a family of + channels that are activated by exterl protons. The family includes another three members ASIC1, ASIC2 and ASIC4. The ASICs are in fact part of a larger superfamily termed degenerin/epithelial + channels (DEG/EC) and share with it the same basic characteristics: two transmembrane spanning domains, a large extracellular domain and short intracellular N and C termini. There are two recognized splice variants of the ASIC2 gene that differ on their N-termini, ASIC2a and ASIC2b that have different tissue distributions and functions. ASIC2a is highly expressed in the central nervous system (CNS) and is less expressed in the peripheral nervous system (PNS) while ASIC2b is prominently expressed in the latter. The functiol channel is composed of 4 subunits that can be assembled as homo or heterotetramers with the other ASIC subunits. The ASIC2b splice variant does not appear to be functiol when expressed alone but it can modify the properties of ASIC2a and ASIC3 when co-expressed. The ASIC2 protein has been proposed to be involved in mechanosensation and sensory transduction.

General readings

Saugstad,J.A., et al., (2004) J. Biol. Chem. 279 (53), 55514-55519

12 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ASIC2 / ACCN1 antibody

  Rabbit polyclonal Anti-ASIC2a  
Western blot analysis of rat brain membranes: 1. Anti-ASIC2a antibody , (1:200). 2. Anti-ASIC2a antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

ASIC2 / ACCN1 antibody

  Rabbit Polyclonal Anti-ACCN1 Antibody  
WB Suggested Anti-ACCN1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ASIC2 / ACCN1 antibody

  Rabbit Polyclonal Anti-ACCN1 Antibody  
WB Suggested Anti-ACCN1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: THP-1 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

ASIC2 / ACCN1 (Center) antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with ACCN1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

ASIC2 - human gene knockout kit via CRISPR

ASIC2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ASIC2 - human gene knockout kit via CRISPR

ASIC2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ASIC2 - human gene knockout kit via CRISPR

ASIC2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ASIC2 - human gene knockout kit via CRISPR

ASIC2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ASIC2 / ACCN1 (transcript variant 2)

  Recombinant protein of human amiloride-sensitive cation channel 1, neuronal (ACCN1), transcript variant 2  
ASIC2 / ACCN1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

ASIC2 overexpression lysate

ASIC2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

ASIC2 overexpression lysate

ASIC2 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ASIC2 (mGFP-tagged) - Human amiloride-sensitive cation channel 1, neuronal (ACCN1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, ASIC2 (mGFP-tagged) - Human amiloride-sensitive cation channel 1, neuronal (ACCN1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

12 Item(s)

per page
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