ASIC3 / ACCN3 antibody

Principal name

ASIC3 / ACCN3 antibody

Alternative names for ASIC3 / ACCN3 antibody

SLNAC1, TNAC1, Amiloride-sensitive cation channel 3, Neuronal amiloride-sensitive cation channel 3, Acid-sensing ion channel 3, Testis sodium channel 1

SwissProt ID

O35240 (Rat), Q6X1Y6 (Mouse), Q9UHC3 (Human)

Gene ID

286920 (Accn3), 9311 (ASIC3), 171209

Available reactivities

Rt (Rat), Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse)

Available hosts

Guinea Pig, Rabbit, Mouse

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of ASIC3 / ACCN3 antibody

ASIC3 is a member of a family of + channels that are activated by exterl protons. The family includes another three members ASIC1, ASIC2 and ASIC4. The ASICs are in fact part of a larger superfamily termed degenerin/epithelial + channels (DEG/EC) and share with it the same basic characteristics: two transmembrane spanning domains, a large extracellular domain and short intracellular N and C termini. The functiol channel is composed of 4 subunits that can be assembled as homo or heterotetramers with the other ASIC subunits. A drop in exterl pH opens the channel resulting in an inward cation current that is quickly ictivated even in the continuous presence of protons in the medium, although a small residual current may persist. Several lines of evidence indicate that ASIC3 may function as a pain sensor. First, it is specifically located in dorsal root ganglia (DRG) neurons and in nociceptors that are involved in pain detection and transmission. In addition, in conditions such as inflammation and cardiac ischemia that include tissue acidosis and thus pain, ASIC3 currents have been detected. Filly, ASIC3 deficient mice display altered sensitivity to high intensity pain produced by heat or acid. Interestingly, while in rats ASIC3 is expressed almost exclusively in DRG neurons, in humans its expression is more widespread suggesting a more extensive role in human nociception.

General readings

Jones,N.G., et al., (2004) J. Neurosci. 24(48), 10974-9

11 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ASIC3 / ACCN3 antibody

Western blot analysis of rat DRG lysate: 1. Anti-ASIC3 antibody , (1:200). 2. Anti-ASIC3 antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

ASIC3 / ACCN3 antibody

WB Suggested Anti-ACCN3 Antibody Titration: 2.5 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Kidney Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ASIC3 / ACCN3 antibody

ASIC3 / ACCN3 Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

ASIC3 / ACCN3 antibody

Human kidney; ACCN3 antibody - N-terminal region (ARP35152_T100) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

ASIC3 / ACCN3 antibody

ASIC3 / ACCN3 Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

ASIC3 / ACCN3 antibody

ASIC3 expression compared to other nociceptive ion channels. DRG sections double-labeled for ASIC3 (red) and either P2X3 (green, A) or TRPV1 (green, B); double-labeled cells are yellow or orange. Circle charts show the relative distribution of the three receptors among all DRG neurons. ASIC3 and P2X3 expression overlapped in only 4% of neurons, while some 35% of ASIC3-positive neurons also express TRPV1. The rare cells positive for both ASIC3 and P2X3 were large (eg. cell at lower left in A). 1406 cells counted for A; 995 for B. C, D, electrophysiological recordings reveal a qualitatively similar expression pattern for currents conforming to ASIC3, P2X3, or TRPV1. The cell that generated the currents in C counts as a co-expressor of ASIC3 and P2X3, fitting into the yellow bin in the circle plot. The cell in D is a co-expressor of ASIC3 and TRPV1. Cells were counted positive if they had at least 0.3 nA of current in response to pH 6.8 (ASIC3+), 50 μM ATP (P2X3+; transient current only), or 1 μM capsaicin (TRPV1). 182 cells recorded for C; 169 for D. Guinea Pig Serum Rt C
50 µl / €230.00
  Neuromics Antibodies

ASIC3 / ACCN3 antibody

ASIC3 expression compared to other nociceptive ion channels. DRG sections double-labeled for ASIC3 (red) and either P2X3 (green, A) or TRPV1 (green, B); double-labeled cells are yellow or orange. Circle charts show the relative distribution of the three receptors among all DRG neurons. ASIC3 and P2X3 expression overlapped in only 4% of neurons, while some 35% of ASIC3-positive neurons also express TRPV1. The rare cells positive for both ASIC3 and P2X3 were large (eg. cell at lower left in A). 1406 cells counted for A; 995 for B. C, D, electrophysiological recordings reveal a qualitatively similar expression pattern for currents conforming to ASIC3, P2X3, or TRPV1. The cell that generated the currents in C counts as a co-expressor of ASIC3 and P2X3, fitting into the yellow bin in the circle plot. The cell in D is a co-expressor of ASIC3 and TRPV1. Cells were counted positive if they had at least 0.3 nA of current in response to pH 6.8 (ASIC3+), 50 μM ATP (P2X3+; transient current only), or 1 μM capsaicin (TRPV1). 182 cells recorded for C; 169 for D. Guinea Pig Serum Rt C
0.15 ml / €440.00
  Neuromics Antibodies

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ASIC3 (mGFP-tagged)-Human amiloride-sensitive cation channel 3 (ACCN3), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, ASIC3 (mGFP-tagged)-Human amiloride-sensitive cation channel 3 (ACCN3), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, ASIC3 (Myc-DDK-tagged)-Human amiloride-sensitive cation channel 3 (ACCN3), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, ASIC3 (Myc-DDK-tagged)-Human amiloride-sensitive cation channel 3 (ACCN3), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,060.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Asic3 (GFP-tagged) - Mouse amiloride-sensitive cation channel 3 (Accn3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Asic3 (GFP-tagged) - Mouse amiloride-sensitive cation channel 3 (Accn3), 200 uL, >10^7 TU/mL  
200 µl / €1,160.00
  OriGene Technologies, Inc.

Lenti ORF particles, Asic3 (Myc-DDK-tagged) - Mouse amiloride-sensitive cation channel 3 (Accn3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Asic3 (Myc-DDK-tagged) - Mouse amiloride-sensitive cation channel 3 (Accn3), 200 uL, >10^7 TU/mL  
200 µl / €1,040.00
  OriGene Technologies, Inc.

11 Item(s)

per page
  • LinkedIn