ASIC3 / ACCN3 antibody

Principal name

ASIC3 / ACCN3 antibody

Alternative names for ASIC3 / ACCN3 antibody

SLNAC1, TNAC1, Amiloride-sensitive cation channel 3, Neuronal amiloride-sensitive cation channel 3, Acid-sensing ion channel 3, Testis sodium channel 1

SwissProt ID

O35240 (Rat), Q6X1Y6 (Mouse), Q9UHC3 (Human)

Gene ID

286920 (Accn3), 9311 (ASIC3)

Available reactivities

Rt (Rat), Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Guinea Pig, Rabbit, Goat, Mouse

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of ASIC3 / ACCN3 antibody

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium. Alternative splicing of this gene generates three transcript variants encoding distinct isoforms.; FUNCTION: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.; SUBUNIT: Homotetramer or heterotetramer with other ASIC proteins (Probable). Interacts with STOM and DLG4. Interacts with LIN7B, MAGI1/BAIAP1, GOPC and ACCN1.; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm. Note: Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells.; TISSUE SPECIFICITY: Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis.; DEVELOPMENTAL STAGE: Expressed in fetal tissues, expression increases in lung and kidney adult tissues.

General readings

Sutherland SP et al. Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons. Proc Natl Acad Sci U S A 98:711-6 (2001). PubMed PMID: 11120882

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ASIC3 / ACCN3 antibody

Western blot analysis of rat DRG lysate: 1. Anti-ASIC3 antibody , (1:200). 2. Anti-ASIC3 antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

ASIC3 / ACCN3 antibody

WB Suggested Anti-ACCN3 Antibody Titration: 2.5 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Kidney Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ASIC3 / ACCN3 antibody

ASIC3 / ACCN3 Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

ASIC3 / ACCN3 antibody

Human kidney; ACCN3 antibody - N-terminal region (ARP35152_T100) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

ASIC3 / ACCN3 antibody

ASIC3 / ACCN3 Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

ASIC3 / ACCN3 antibody

ASIC3 expression compared to other nociceptive ion channels. DRG sections double-labeled for ASIC3 (red) and either P2X3 (green, A) or TRPV1 (green, B); double-labeled cells are yellow or orange. Circle charts show the relative distribution of the three receptors among all DRG neurons. ASIC3 and P2X3 expression overlapped in only 4% of neurons, while some 35% of ASIC3-positive neurons also express TRPV1. The rare cells positive for both ASIC3 and P2X3 were large (eg. cell at lower left in A). 1406 cells counted for A; 995 for B. C, D, electrophysiological recordings reveal a qualitatively similar expression pattern for currents conforming to ASIC3, P2X3, or TRPV1. The cell that generated the currents in C counts as a co-expressor of ASIC3 and P2X3, fitting into the yellow bin in the circle plot. The cell in D is a co-expressor of ASIC3 and TRPV1. Cells were counted positive if they had at least 0.3 nA of current in response to pH 6.8 (ASIC3+), 50 μM ATP (P2X3+; transient current only), or 1 μM capsaicin (TRPV1). 182 cells recorded for C; 169 for D. Guinea Pig Serum Rt C
50 µl / €230.00
  Neuromics Antibodies

ASIC3 / ACCN3 antibody

ASIC3 expression compared to other nociceptive ion channels. DRG sections double-labeled for ASIC3 (red) and either P2X3 (green, A) or TRPV1 (green, B); double-labeled cells are yellow or orange. Circle charts show the relative distribution of the three receptors among all DRG neurons. ASIC3 and P2X3 expression overlapped in only 4% of neurons, while some 35% of ASIC3-positive neurons also express TRPV1. The rare cells positive for both ASIC3 and P2X3 were large (eg. cell at lower left in A). 1406 cells counted for A; 995 for B. C, D, electrophysiological recordings reveal a qualitatively similar expression pattern for currents conforming to ASIC3, P2X3, or TRPV1. The cell that generated the currents in C counts as a co-expressor of ASIC3 and P2X3, fitting into the yellow bin in the circle plot. The cell in D is a co-expressor of ASIC3 and TRPV1. Cells were counted positive if they had at least 0.3 nA of current in response to pH 6.8 (ASIC3+), 50 μM ATP (P2X3+; transient current only), or 1 μM capsaicin (TRPV1). 182 cells recorded for C; 169 for D. Guinea Pig Serum Rt C
0.15 ml / €440.00
  Neuromics Antibodies

ASIC3 / ACCN3 antibody

Immunohistochemistry: Amiloride-sensitive cation channel 3 Antibody [NB100-2067] - ASIC3 labeling is done on cryostat sections of rat DRG using HRP-DAB detection (brown color). Guinea Pig IgG Aff - Purified Rt C, ICC/IF, P
50 µl / €340.00
  Novus Biologicals Inc.

ASIC3 / ACCN3 antibody

ASIC3 / ACCN3 Rabbit Serum Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

ASIC3 / ACCN3 antibody

ASIC3 / ACCN3 Goat Purified Ms, Rt C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

10 Item(s)

per page
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