ASIC4 / ACCN4 antibody

Principal name

ASIC4 / ACCN4 antibody

Alternative names for ASIC4 / ACCN4 antibody

Amiloride-sensitive cation channel 4, Acid-sensing ion channel 4

SwissProt ID

Q7TNS7 (Mouse), Q96FT7 (Human), Q9JHS6 (Rat)

Gene ID

55515 (ASIC4), 63882 (Accn4), 241118

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Eq (Equine), GP (Guinea Pig), Ze (Zebrafish)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB)

Background of ASIC4 / ACCN4 antibody

Acid-sensing ion channels (ASICs) are + channels activated by exterl protons. ASIC4 is a member of the ASIC family that includes another three members: ASIC1, ASIC2 and ASIC3. The ASIC family is in fact part of a large channel superfamily known as degenerin/epithelial + channels (DEG/EC) and share the same basic characteristics: two transmembrane spanning domains, a large extracellular domain and short intracellular N and C termini. The functiol ASIC channel is composed of 4 subunits, which can form either a homo or heterotetramer. The subunit composition of the tetrameric channel will determine its biophysical properties such as pH sensitivity, ictivation kinetics and channel pharmacology. In fact, the ASIC4 protein does not appear to function as a proton-gated channel when expressed alone in heterologous systems and therefore a modulatory role for this subunit has been proposed. Expression of the ASIC4 protein has been detected in brain, pituitary gland, spil cord and inner ear. The functiol significance of ASIC4 expression in these tissues still awaits clarification.

General readings

Strausberg,R.L., et al., (2002) Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ASIC4 / ACCN4 antibody

  Rabbit polyclonal Anti-ASIC4  
Western blot analysis of ND7/23 cell line (lanes 1 and 3) and rat brain (lanes 2 and 4) lysates: 1, 2. Anti-ASIC4 antibody , (1:200). 3, 4. Anti-ASIC4 antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

ASIC4 / ACCN4 antibody

  Rabbit Polyclonal Anti-ACCN4 Antibody  
WB Suggested Anti-ACCN4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:12500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

ASIC4 / ACCN4 antibody

  Rabbit Polyclonal Anti-ACCN4 Antibody  
WB Suggested Anti-ACCN4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ASIC4 / ACCN4 (N-term) antibody

ACCN4 Antibody (N-term) (Cat. #AP50045PU-N) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ACCN4 antibody detected the ACCN4 protein (arrow) Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Asic4 - mouse gene knockout kit via CRISPR

Asic4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Asic4 - mouse gene knockout kit via CRISPR

Asic4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Asic4 - mouse gene knockout kit via CRISPR

Asic4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Asic4 - mouse gene knockout kit via CRISPR

Asic4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ASIC4 / ACCN4 (transcript variant 2)

  Recombinant protein of human amiloride-sensitive cation channel 4, pituitary (ACCN4), transcript variant 2  
ASIC4 / ACCN4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

ASIC4 overexpression lysate

ASIC4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Asic4 (GFP-tagged) - Mouse amiloride-sensitive cation channel 4, pituitary (Accn4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Asic4 (GFP-tagged) - Mouse amiloride-sensitive cation channel 4, pituitary (Accn4), 200 uL, >10^7 TU/mL  
200 µl / €1,170.00
  OriGene Technologies, Inc.

Lenti ORF particles, Asic4 (Myc-DDK-tagged) - Mouse amiloride-sensitive cation channel 4, pituitary (Accn4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Asic4 (Myc-DDK-tagged) - Mouse amiloride-sensitive cation channel 4, pituitary (Accn4), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Asic4 (GFP-tagged ORF) - Rat amiloride-sensitive cation channel 4, pituitary (Accn4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Asic4 (GFP-tagged ORF) - Rat amiloride-sensitive cation channel 4, pituitary (Accn4), 200 uL, >10^7 TU/mL  
200 µl / €1,170.00
  OriGene Technologies, Inc.

Lenti ORF particles, Asic4 (Myc-DDK-tagged ORF) - Rat amiloride-sensitive cation channel 4, pituitary (Accn4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Asic4 (Myc-DDK-tagged ORF) - Rat amiloride-sensitive cation channel 4, pituitary (Accn4), 200 uL, >10^7 TU/mL  
200 µl / €1,048.00
  OriGene Technologies, Inc.

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