ASIC4 / ACCN4 antibody

Principal name

ASIC4 / ACCN4 antibody

Alternative names for ASIC4 / ACCN4 antibody

Amiloride-sensitive cation channel 4, Acid-sensing ion channel 4

SwissProt ID

Q7TNS7 (Mouse), Q96FT7 (Human), Q9JHS6 (Rat)

Gene ID

55515 (ASIC4), 63882 (Accn4)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Eq (Equine), GP (Guinea Pig), Ze (Zebrafish)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Paraffin Sections (P)

Background of ASIC4 / ACCN4 antibody

ACCN4 belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. ACCN4 is predominantly expressed in the pituitary gland, and might be a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder. FUNCTION: Probable cation channel with high affinity for sodium. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. SUBUNIT: Homotetramer or heterotetramer with other ASIC proteins (Probable). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: This gene is predominantly expressed in the pituitary gland. Expressed in brain, spinal chord and dorsal root ganglion (DRG). Expressed by a subset of sensory neurons in the DRG. Expressed by granule cells in the cerebellar cortex. In hippocampus, expression is detected in dentate gyrus granule cells, in pyramidal cells of CA1-CA3 subfields and in interneurons of the striatum oriens and radiatum of all subfields. In cerebral cortex expressed in small, medium and large pyramidal cells in layers 2, 3 and 5 respectively. Also expressed in striatum, globus pallidus, inferior and superior calliculi, amygdala, magnocellular preoptic nucleus, islands of Calleja and large neurons of olfactory tubercules. DEVELOPMENTAL STAGE: Highly expressed in newborn spinal chord but hardly detected in the cerebellum compared to adult. Expressed at postnatal day 1 in ependymal cells lining the central canal of spinal chord and in motor neurons. In adult, expression decreases in ependymal cells and increases in motor neurons. The number of positive interneurons decreases but the individual interneuron expression increases in adult spinal chord compared to newborn. MISCELLANEOUS: In vitro, has no proton-gated channel activity.

General readings

Strausberg,R.L., et al., (2002) Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903

8 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ASIC4 / ACCN4 antibody

Western blot analysis of ND7/23 cell line (lanes 1 and 3) and rat brain (lanes 2 and 4) lysates: 1, 2. Anti-ASIC4 antibody , (1:200). 3, 4. Anti-ASIC4 antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

ASIC4 / ACCN4 antibody

WB Suggested Anti-ACCN4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:12500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

ASIC4 / ACCN4 antibody

WB Suggested Anti-ACCN4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ASIC4 / ACCN4 (N-term) antibody

ACCN4 Antibody (N-term) (Cat. #AP50045PU-N) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ACCN4 antibody detected the ACCN4 protein (arrow) Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ASIC4 / ACCN4 antibody

ASIC4 / ACCN4 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

ASIC4 / ACCN4 antibody

Human Jurkat; WB Suggested Anti-ACCN4 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:500. Positive Control: Jurkat cell lysate; ACCN4 antibody - N-terminal region (ARP35536_P050) in Human Jurkat cells using Western Blot Rabbit IgG Aff - Purified Bov, Can, Hu, Ms, Rb, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ASIC4 / ACCN4 (transcript variant 2)

ASIC4 / ACCN4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

ASIC4 overexpression lysate

ASIC4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

8 Item(s)

per page
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