ASPSCR1 antibody

Principal name

ASPSCR1 antibody

Alternative names for ASPSCR1 antibody

ASPL, RCC17, TUG, UBXD9, UBXN9, Tether containing UBX domain for GLUT4, Alveolar soft part sarcoma chromosomal region candidate gene 1 protein, Alveolar soft part sarcoma locus, Renal papillary cell carcinoma protein 17, UBX domain-containing protein 9

SwissProt ID

Q8VBT9 (Mouse), Q9BZE9 (Human)

Gene ID

79058 (ASPSCR1), 68938 (Aspscr1)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), EPair for Elisa (EPair)

Background of ASPSCR1 antibody

ASPSCR1 is tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface.
Insulin stimulates glucose uptake in fat and muscle by mobilizing the GLUT4 glucose transporter. GLUT4 is sequestered intracellularly in the absence of insulin, and is redistributed to the plasma membrane within minutes of insulin stimulation. Bogan et al. (2003) described a functional screen to identify proteins that modulate GLUT4 distribution, and identified TUG as a putative tether, containing a UBX domain, for GLUT4. They identified the ASPL protein as the probable human homolog of murine TUG. In truncated form, TUG acts in a dominant-negative manner to inhibit insulin-stimulated GLUT4 redistribution in Chinese hamster ovary cells and 3T3-L1 adipocytes. Full-length TUG forms a complex specifically with GLUT4; in 3T3-L1 adipocytes, this complex is present in unstimulated cells and is largely disassembled by insulin. Endogenous TUG is localized with the insulin-mobilizable pool of GLUT4 in unstimulated 3T3-L1 adipocytes, and is not mobilized to the plasma membrane by insulin. Distinct regions of TUG are required to bind GLUT4 and to retain GLUT4 intracellularly in transfected, nonadipose cells. Bogan et al. (2003) concluded that TUG traps endocytosed GLUT4 and tethers it intracellularly, and that insulin mobilizes this pool of retained GLUT4 by releasing this tether. Bogan et al. (2003) found that TUG exists in 2 isoforms, the longer of which contains a sequence at the amino terminus with similarity to ubiquitin that is predicted to be 550 residues long. The probable start codon in the short form is equivalent to methionine-78 of the long form.

General readings

Bogan JS, Hendon N, et al. (2003). Nature. 425(6959):727-33.Argani P, Antonescu CR, et al. (2001). Am J Pathol. 159(1):179-92.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ASPSCR1 antibody

  Anti-ASPSCR1 Rabbit Polyclonal Antibody  
Predicted band size: 70-75 kDa . Positive control: HL60 cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lysate: 30 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ASPSCR1 antibody

  Rabbit Polyclonal Anti-ASPSCR1 Antibody  
WB Suggested Anti-ASPSCR1 Antibody; Titration: 1.0 ug/ml; Positive Control: Fetal Lung Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

ASPSCR1 (C-term) antibody

Western blot analysis of ASPSCR1/TUG Antibody (C-term) (Cat.#AP17891PU-N) in Hela cell line lysates (35ug/lane). ASPSCR1 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

ASPSCR1 (N-term) antibody

ASPSCR1 Antibody (N-term) (Cat. #AP50277PU-N) western blot analysis in A2058 cell line lysates (35µg/lane).This demonstrates the ASPSCR1 antibody detected the ASPSCR1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

ASPSCR1 - human gene knockout kit via CRISPR

ASPSCR1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ASPSCR1 - human gene knockout kit via CRISPR

ASPSCR1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ASPSCR1 - human gene knockout kit via CRISPR

ASPSCR1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ASPSCR1 - human gene knockout kit via CRISPR

ASPSCR1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Aspscr1 - mouse gene knockout kit via CRISPR

Aspscr1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Aspscr1 - mouse gene knockout kit via CRISPR

Aspscr1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ASPSCR1

  Recombinant protein of human alveolar soft part sarcoma chromosome region, candidate 1 (ASPSCR1)  
ASPSCR1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ASPSCR1 (1-553, His-tag)

ASPSCR1 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €730.00
  Acris Antibodies GmbH

ASPSCR1 (1-553, His-tag)

ASPSCR1 Human Purified > 85 % by SDS - PAGE E. coli
20 µg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

ASPSCR1 overexpression lysate

ASPSCR1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ASPSCR1 (mGFP-tagged) - Human alveolar soft part sarcoma chromosome region, candidate 1 (ASPSCR1), 200 uL, >10^7 TU/mL

Lenti ORF particles, ASPSCR1 (mGFP-tagged) - Human alveolar soft part sarcoma chromosome region, candidate 1 (ASPSCR1), 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, ASPSCR1 (Myc-DDK tagged) - Human alveolar soft part sarcoma chromosome region, candidate 1 (ASPSCR1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, ASPSCR1 (Myc-DDK tagged) - Human alveolar soft part sarcoma chromosome region, candidate 1 (ASPSCR1) , 200 uL, >10^7 TU/mL  
200 µl / €1,060.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Aspscr1 (GFP-tagged) - Mouse alveolar soft part sarcoma chromosome region, candidate 1 (human) (Aspscr1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Aspscr1 (GFP-tagged) - Mouse alveolar soft part sarcoma chromosome region, candidate 1 (human) (Aspscr1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, Aspscr1 (GFP-tagged) - Mouse alveolar soft part sarcoma chromosome region, candidate 1 (human) (Aspscr1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Aspscr1 (GFP-tagged) - Mouse alveolar soft part sarcoma chromosome region, candidate 1 (human) (Aspscr1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,080.00
  OriGene Technologies, Inc.

Lenti ORF particles, Aspscr1 (GFP-tagged) - Mouse alveolar soft part sarcoma chromosome region, candidate 1 (human) (Aspscr1), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, Aspscr1 (GFP-tagged) - Mouse alveolar soft part sarcoma chromosome region, candidate 1 (human) (Aspscr1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, Aspscr1 (Myc-DDK-tagged) - Mouse alveolar soft part sarcoma chromosome region, candidate 1 (human) (Aspscr1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Aspscr1 (Myc-DDK-tagged) - Mouse alveolar soft part sarcoma chromosome region, candidate 1 (human) (Aspscr1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €970.00
  OriGene Technologies, Inc.

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