Ataxin-2 antibody

Principal name

Ataxin-2 antibody

Alternative names for Ataxin-2 antibody

Ataxin 2, ATXN2, ATX2, SCA2, TNRC13, Spinocerebellar ataxia type 2 protein, Trinucleotide repeat-containing gene 13 protein

SwissProt ID

O70305 (Mouse), Q99700 (Human)

Gene ID

6311 (ATXN2)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Por (Porcine), Mky (Monkey), Eq (Equine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of Ataxin-2 antibody

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 12, and it has been determined that the diseased allele contains 36-52 CAG repeats, compared to 22-23 in the normal allele. A potential transcript variant, missing an internal coding exon, has been described; however, its full-length nature is not certain.

General readings

1 Pulst, S.-M., Nechiporuk, A., Nechiporuk, T., Gispert, S., Chen, X.-N., Lopes-Cendes, I., Pearlman, S., Starkman, S., Orozco-Diaz, G., Lunkes, A., DeJong, P., Rouleau, G. A., Auburger, G., Korenberg, J. R., Figueroa, C., Sahba, S. Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.
2 Ralser, M., Nonhoff, U., Albrecht, M., Lengauer, T., Wanker, E. E., Lehrach, H., Krobitsch, S. Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways. Hum. Molec. Genet. 14: 2893-2909, 2005.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ataxin-2 antibody

WB Suggested Anti-ATXN2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: PANC1 cell lysate Rabbit Aff - Purified Bov, Can, Hu, Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

Ataxin-2 antibody

Ataxin-2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Ataxin-2 antibody

Western blot analysis of extracts from HepG2/Jurkat/293 cells, using ATXN2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €205.00
  Assay Biotech

Ataxin-2 antibody

Western blot analysis of extracts from HepG2/Jurkat/293 cells, using ATXN2 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €310.00
  Assay Biotech

Ataxin-2 antibody

Human PANC1; WB Suggested Anti-ATXN2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: PANC1 cell lysate; ATXN2 antibody - middle region (ARP38210_P050) in Human PANC1 cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

Ataxin-2 antibody

Ataxin-2 Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

Ataxin-2 antibody

Immunohistochemical analysis of Ataxin 2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky IP, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Ataxin-2 antibody

Immunohistochemical analysis of Ataxin 2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky IP, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Ataxin-2 antibody

Immunohistochemical analysis of Ataxin 2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky IP, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Ataxin-2 antibody

Immunohistochemistry: ATX2/SCA2 Antibody [NB100-58797] -  Ataxin-2 Antibody [NB100-58797] - Detection of Ataxin-2 in cerebellar Purkinje neurons using NB100-58797 at 2.5ug/ml. Rabbit Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

Ataxin-2 antibody

Immunohistochemistry-Paraffin: ATX2 Antibody [NBP1-90062] - Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in neurons. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Ataxin-2 antibody

Immunohistochemistry-Paraffin: ATX2 Antibody [NBP1-90063] - Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells. Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Ataxin-2

Ataxin-2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Ataxin-2

Ataxin-2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

14 Item(s)

per page
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