Ataxin-3 antibody

Principal name

Ataxin-3 antibody

Alternative names for Ataxin-3 antibody

ATXN3, ATX3, MJD, MJD1, SCA3, Machado-Joseph disease protein 1, Spinocerebellar ataxia type 3 protein

SwissProt ID

O35815 (Rat), P54252 (Human), Q9CVD2 (Mouse), Q9W689 (Chick)

Gene ID

4287 (ATXN3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Can (Canine), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Sh (Sheep), Ze (Zebrafish)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Ataxin-3 antibody

ATXN3(ataxin 3), also known as AT3, MJD GENE, MJD1, SCA3 GENE, ATX3, JOS, Spinocerebellar ataxia-3, Machado-Joseph disease protein 1, is a protein that in humans is encoded by the ATXN3 gene. ATXN3 range in size from 360 to 374 amino acids. Using Northern blot analysis showed that ATXN3 mRNA was ubiquitously expressed in human tissues. They detected at least 4 ATXN3 transcripts of 1.4, 1.8, 4.5, and 7.5 kb and suggested that the different mRNA species probably result from differential splicing and polyadenylation.Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by the ATXN3 gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is an inverse correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Ataxin-3 interacted with 2 human homologs of the yeast DNA repair protein RAD23, HHR23A (RAD23A) and HHR23B (RAD23B). Both normal and mutant ataxin-3 proteins interacted with the ubiquitin-like domain at the N terminus of the HHR23 proteins, which is a motif important for nucleotide excision repair. However, in HEK 293 cells, HHR23A was recruited to intranuclear inclusions formed by the mutant ataxin-3 through its interaction with ataxin-3.

General readings

Doss Pepe EW., et al. (2003). Mol Cell Biol. 23(18):6469-83.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ataxin-3 antibody

Hela cell nuclear extracts were resolved by electrophoresis, transferred to nitrocellulose, and probed with purified monoclonal anti-Ataxin-3 Antibody Clone 1H9-2. Proteins were visualized using an anti-mouse-IgG secondary conjugated to HRP and chemiluminescence detection. Mouse IgG1 1H9-2 Purified Hu WB
0.1 mg / €360.00
  Acris Antibodies GmbH

Ataxin-3 antibody

Hela cell nuclear extracts were resolved by electrophoresis, transferred to nitrocellulose, and probed with purified monoclonal anti-Ataxin-3 Antibody Clone 1H9-2. Proteins were visualized using an anti-mouse-IgG secondary conjugated to HRP and chemiluminescence detection. Mouse IgG1 1H9-2 Purified Hu WB
25 µg / €240.00
  Acris Antibodies GmbH

Ataxin-3 antibody

Western blot analysis of MCF-7 cell lysate using ATXN3 antibody. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Ataxin-3 (Center) antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with ATXN3 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Ataxin-3 (120-250) antibody

Ataxin-3 Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt WB
20 µl / €50.00
  SICGEN

Ataxin-3 (120-250) antibody

Ataxin-3 Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt WB
0.6 mg / €320.00
  SICGEN

Ataxin-3 (120-250) antibody

Ataxin-3 Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt WB
1.5 mg / €450.00
  SICGEN

Ataxin-3 antibody

Ataxin 3 antibody detects Ataxin 3 protein by western blot analysis. Mouse tissue extracts (50 ug) was separated by 10 % SDS-PAGE, and blotted with Ataxin 3 antibody (TA308320) diluted by 1:500 Rabbit IgG Aff - Purified Hu, Ms P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Ataxin-3 antibody

Lanes: Lane 1: 2 ug hATX3 (isoform2); Josephin domain(1-182); Lane 2: 2 ug hATX3 (isoform2); C-terminal truncated Atx3 (1-264); Lane 3: 2ug hATX3 (isoform2); Lane 4: 2ug other protein; Primary Antibody Dilution: 1: 10, 000; Secondary Antibody: Anti-rabbit Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Sh, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Ataxin-3 antibody

Paraffin Sections of Human Brain Cortex stained with Ataxin-3 antibody Cat.-No AM21054PU-N after antigen retrieval Proteinase K pretreatment. Mouse IgG1 SCA-1H9 Ascites Hu, Mky, Ms, Rt E, F, P, WB
0.1 ml / €500.00
  Acris Antibodies GmbH

Ataxin-3 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

Ataxin-3 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with ATXN3 polyclonal antibody ( Cat # PAB1728 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Ataxin-3 (N-term) antibody

Human; . Lanes: Lane 1: 2ug hATX3 (isoform2); Josephin domain(1-182). Lane 2: 2ug hATX3 (isoform2); C-terminal truncated Atx3 (1-264). Lane 3: 2ug hATX3 (isoform2). Lane 4: 2ug other protein. Primary Antibody Dilution: 1:10,000. Secondary Antibody: Anti-rabbit HRP. Secondary Antibody Dilution: 1:20,000. Gene Name: ATXN3. Submitted by: Dr. Maria Macedo, Instituto de Biologia Molecular e Celular.; ATXN3 antibody - N-terminal region (ARP50507_P050) in Human cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Ataxin-3 antibody

Ataxin-3 Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

Ataxin-3 antibody

Western Blot:Ataxin 3 Antibody  [NBP1-32083]-  analysis of ATXN3 expression in transfected 293T cell line by ATXN3 polyclonal antibody. A:Non-transfected lysate. B:ATXN3 transfected lysate. 12% SDS PAGE diluted at 1:500 Rabbit IgG Hu ICC/IF, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Ataxin-3 (transcript variant 1)

Ataxin-3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Ataxin-3 (1-370)

Ataxin-3 Human Purified > 90 % by SDS - PAGE E. coli
0.25 mg / €750.00
  Acris Antibodies GmbH

Ataxin-3 (1-370)

Ataxin-3 Human Purified > 90 % by SDS - PAGE E. coli
50 µg / €300.00
  Acris Antibodies GmbH

Ataxin-3

Ataxin-3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Ataxin-3

Ataxin-3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

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