Ataxin-7 antibody

Principal name

Ataxin-7 antibody

Alternative names for Ataxin-7 antibody

Ataxin 7, ATXN7, SCA7, Spinocerebellar ataxia type 7 protein

SwissProt ID

O15265 (Human), Q8R4I1 (Mouse)

Gene ID

6314 (ATXN7)

Available reactivities

Hu (Human), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of Ataxin-7 antibody

ATXN7 is involved in neurodegeneration. ATXN7 acts as component of the STAGA transcription coactivator-HAT complex. ATXN7 mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation.The autosomal domint cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spil cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, desigted spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retil degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with Spinocerebellar ataxia-7, contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The exact function of this gene is not known, however, since the encoded protein contains a nuclear localization sequence, and is found to be localized in the nucleus, it has been postulated to be a potential transcription factor. Altertive splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.

General readings

J. Cell Biol., Jul 2006; 174: 65 - 76.

6 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ataxin-7 antibody

WB Suggested Anti-ATXN7 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: ACHN cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Ataxin-7 antibody

Ataxin-7 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

Ataxin-7 antibody

Human ACHN; WB Suggested Anti-ATXN7 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: ACHN cell lysate; ATXN7 antibody - middle region (ARP33364_P050) in Human ACHN cells using Western Blot Rabbit Aff - Purified Can, Chk, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Ataxin-7 antibody

Western Blot: Ataxin 7 Antibody [NBP1-42657]-Whole cell lysate (5, 15 and 50 mcg) from 293T cells.  Affinity purified rabbit anti-Ataxin-7 antibody used for WB at 0.4 mcg/ml. Rabbit Hu WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Ataxin-7 antibody

Immunohistochemistry-Paraffin: Ataxin 7 Antibody [NBP1-90236] - Immunohistochemical staining of human skeletal muscle shows strong cytoplasmic positivity in subsets of myocytes. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

ATXN7 overexpression lysate

ATXN7 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

6 Item(s)

per page
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