ATF2 antibody

Principal name

ATF2 antibody

Alternative names for ATF2 antibody

ATF-2, CREB2, CREBP1, Activating transcription factor 2, CRE-BP1, HB16, CREB-2, Cyclic AMP-dependent transcription factor ATF-2, cAMP-dependent transcription factor ATF-2, cAMP response element-binding protein CRE-BP1, Cyclic AMP-responsive element-binding protein 2

SwissProt ID

O93602 (Chick), P15336 (Human), P16951 (Mouse), Q00969 (Rat)

Gene ID

1386 (ATF2), 81647 (Atf2), 11909

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Can (Canine), Chk (Chicken), African clawed frog, Mky (Monkey), Bov (Bovine), Ze (Zebrafish)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Frozen Sections (C), Electrophoretic Mobility Shift Assay (EMSA), Dot blot (Dot), Flow Cytometry (F)

Background of ATF2 antibody

ATF2 (Activating Transcription Factor 2, CREBP, HB16, CREB2, TREB7) is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.

General readings

1. Rodríguez M  et al. The Unfolded Protein Response and the Phosphorylations of Activating Transcription Factor 2 in the trans-Activation of il23a Promoter Produced by ß-Glucans. J Biol Chem 289:22942-57 (2014). WB ; Mouse .
2. Diring J  et al. A Cytoplasmic Negative Regulator Isoform of ATF7 Impairs ATF7 and ATF2 Phosphorylation and Transcriptional Activity. PLoS One 6:e23351 (2011). WB ; Human .
3. Feng A  et al. Inhibitory effect of baicalin on iNOS and NO expression in intestinal mucosa of rats with acute endotoxemia. PLoS One 8:e80997 (2013). WB ; Rat .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ATF2 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ATF-2 antibody. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

ATF2 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ATF-2 antibody. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH

ATF2 antibody

Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using ATF-2 antibody. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

ATF2 antibody

Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using ATF-2 antibody. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH

ATF2 (C-term) antibody

  Goat Polyclonal Antibody against ATF2  
TA302732 staining (0.5µg/ml) of Human Placenta lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 12 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ATF2 antibody

  Rabbit Anti-ATF2 (Ser490,498) Antibody (Phospho-Specific)  
Western blot of human melanoma cells incubated with varying doses of the radiomimetic drug NCS showing specific immuno-labeling of the ~74k ATF2 protein phosphorylated at Ser490 and Ser498. Rabbit IgG Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATF2 antibody

  Rabbit polyclonal anti-ATF2 (Ab-73 or 55) antibody  
Western blot analysis of extracts from LOVO cells, using ATF2 Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATF2 antibody

  Rabbit polyclonal anti-ATF2(Ab-71 or 53) antibody  
Western blot analysis of extracts from HeLa cells, using ATF2 (Ab-71 or 53) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATF2 antibody

  Anti-ATF2 Rabbit Polyclonal Antibody  
Predicted cell location: Nucleus. Positive control: Human lymphoma and lung cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human lymphoma cancer tissue using ATF2 antibody at dilution 1/15, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATF2 antibody

  Anti-ATF2 Rabbit Polyclonal Antibody  
Predicted cell location: Nucleus. Positive control: Human lung cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded human lung cancer tissue using ATF2 antibody at dilution 1/15, on the right is treated with the fusion protein. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATF2 antibody

  Anti-ATF2 (Phospho-Thr69 or 51) Rabbit Polyclonal Antibody  
ATF2 Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATF2 antibody

  Anti-ATF2 (Phospho-Thr71 or 53) Rabbit Polyclonal Antibody  
ATF2 Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATF2 antibody

  Anti-ATF2 (Phospho-Ser112 or 94) Rabbit Polyclonal Antibody  
ATF2 Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATF2 antibody

  Rabbit polyclonal ATF2 Antibody (Center T339)  
ATF2 Antibody (pT339) (Cat. #TA324608) western blot analysis in Hela cell line and mouse brain tissue lysates (35ug/lane).This demonstrates the ATF2 antibody detected the ATF2 protein (arrow). Rabbit IgG Purified Hu, Ms WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

ATF2 antibody

  Rabbit Polyclonal ATF2 Antibody  
Western blot analysis of ATF2 expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATF2 antibody

  Rabbit Polyclonal ATF2 Antibody  
Western blot analysis of ATF2 expression in MDA-MB-435 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATF2 antibody

  Rabbit Polyclonal ATF2 (Ser112 or 94) Antibody (Phospho-specific)  
Western blot analysis of ATF2 phosphorylation expression in MDA-MB-435 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATF2 antibody

  Rabbit Polyclonal ATF2 (Ser62 or 44) Antibody (Phospho-specific)  
Western blot analysis of ATF2 phosphorylation expression in TNF-a treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATF2 antibody

  Rabbit Polyclonal ATF2 (Thr69 or 51) Antibody (Phospho-specific)  
Western blot analysis of ATF2 phosphorylation expression in LOVO whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATF2 antibody

  Rabbit Polyclonal ATF2 (Thr71 or 53) Antibody (Phospho-specific)  
Western blot analysis of ATF2 phosphorylation expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

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