ATP1A1 antibody

Principal name

ATP1A1 antibody

Alternative names for ATP1A1 antibody

Sodium pump ATPase subunit alpha-1, Sodium/potassium-transporting ATPase subunit alpha, Sodium/potassium-transporting ATPase subunit alpha-1, Na(+)/K(+) ATPase alpha-1 subunit

SwissProt ID

P04074 (Sheep), P05023 (Human), P05024 (Pig), P06685 (Rat), P50997, Q08DA1 (Bovin), Q8VDN2 (Mouse), Q92123, Q9N0Z6 (Rabit)

Gene ID

481 (ATP1B1), 476 (ATP1A1), 403992, 24211 (Atp1a1)

Available reactivities

Can (Canine), Hu (Human), Mky (Monkey), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Sh (Sheep), Xen (Xenopus), Bov (Bovine), Chk (Chicken), Ze (Zebrafish), Prim (Primate)

Available hosts

Mouse, Chicken, Rabbit

Available applications

Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP), Neutralisation (NEUT), Frozen Sections (C)

Background of ATP1A1 antibody

The ,K-ATPase is an integral membrane heterodimer belonging to the P-type ATPase family. This ion channel uses the energy derived from ATP hydrolysis to maintain membrane potential by driving sodium export and potassium import across the plasma membrane against their electrochemical gradients. It is composed of a catalytic a subunit and a ß subunit . Several phosphorylation sites have been identified for the a1 subunit. Tyr10 is phosphorylated by an as yet undetermined kise , Ser16 and Ser23 are phosphorylated by PKC, and Ser943 is phosphorylated by PKA . All of these sites have been implicated in the regulation of enzyme activity in response to hormones and neurotransmitters, altering trafficking and kinetic properties of ,K-ATPase. Altered phosphorylation in response to angiotensin II stimulates activity in the rat proximal tubule . ,K-ATPase is also involved in other sigl transduction pathways. Insulin regulates its localization in differentiated primary human skeletal muscle cells, and this regulation is dependent on ERK1/2 phosphorylation of the a subunit . ,K-ATPase and Src form a sigling receptor complex that affects regulation of Src kise activity and, subsequently, its downstream effectors.

General readings

This product has been used in:Ball WJ et al. Isolation and characterization of monoclonal antibodies to (Na+ + K+)-ATPase. Biochim Biophys Acta 719:413-23 (1982). PubMed PMID: 6295504
General / background references:Malik B et al. Identification of the amino acids comprising a surface-exposed epitope within the nucleotide-binding domain of the Na+,K(+)-ATPase using a random peptide library. Protein Sci 2:2103-11 (1993). PubMed PMID: 7507752
Abbott A & Ball WJ The epitope for the inhibitory antibody M7-PB-E9 contains Ser-646 and Asp-652 of the sheep Na+,K(+)-ATPase alpha-subunit. Biochemistry 32:3511-8 (1993). PubMed PMID: 7681692
Abbott A & Ball WJ The inhibitory monoclonal antibody M7-PB-E9 stabilizes E2 conformational states of Na+,K(+)-ATPase. Biochemistry 31:11236-43 (1992). PubMed PMID: 1332753
Sweadner KJ Isozymes of the Na+/K+-ATPase. Biochim Biophys Acta 988:185-220 (1989). PubMed PMID: 2541792

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ATP1A1 antibody

Western Blot: Alpha 1 Sodium Potassium ATPase Antibody (464.6) - Western Blot analysis detecting Na, K-ATPase (alpha) in porcine proximal tubule protein, using anti-ATP1A1. Mouse IgG1 Purified Can, Hu, Ms, Por, Prim, Rb, Rt, Sh, Xen F, ICC/IF, P, WB
50 µl / €325.00
  OriGene Technologies, Inc.

ATP1A1 antibody

Western blot analysis of extracts from HeLa cells, using ATP1a1/Na+K+ ATPase1 (Ab-23) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATP1A1 antibody

Predicted cell location: Cytoplasm. Positive control: Human brain tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using ATP1A1 antibody at dilution 1/15, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATP1A1 antibody

Predicted cell location: Cytoplasm. Positive control: Human cervical and colon cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human cervical cancer tissue using ATP1A1 antibody at dilution 1/35, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATP1A1 antibody

Western blot analysis of ATPase expression in PMA treated 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATP1A1 antibody

Western blot analysis of ATP1alpha1/Na+K+ ATPase1 expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATP1A1 antibody

Western blot analysis of extracts of A549 cell and 293 cell line, using ATP1A1 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ATP1A1 antibody

Western blot analysis of lysate from PC-12 cell line,using Rat Atp1a1 Antibody (S23)(Cat. #TA328196).TA328196 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug per lane. Rabbit RB43781 Purified Rt WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

ATP1A1 (alpha) antibody

Western blot analysis of Na+/K+ ATPase α expression in SK-N-SH cells (1), PC12 cells (2) and rat brain extracts (3) using AM26492AF. Mouse IgG1 9A7 Azide Free Hu, Rt ICC/IF, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

ATP1A1 antibody

Western blot (WB) analysis of ATP1A1 antibody (Cat.-No.: AP01364PU-N)  in extracts from HeLa cells. Rabbit Aff - Purified Hu, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

ATP1A1 antibody

Immunohistochemistry Analysis: AP20203PU-N ATP1A1 antibody staining of Paraffin-Embedded Human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

ATP1A1 pSer16 antibody

Western blot analysis of extracts from 293 cells treated with PMA using Phospho-ATPase (Ser16) antibody AP55890PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €340.00
  Acris Antibodies GmbH

ATP1A1 pSer16 antibody

Western blot analysis of extracts from 293 cells treated with PMA using Phospho-ATPase (Ser16) antibody AP55890PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €270.00
  Acris Antibodies GmbH

ATP1A1 antibody

ATP1A1 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

ATP1A1 pSer16 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using ATPase (Phospho-Ser16) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

ATP1A1 pSer16 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using ATPase (Phospho-Ser16) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

ATP1A1 pSer23 antibody

Immunofluorescence analysis of NIH-3T3 cells, using ATP1 alpha1/Na+K+ ATPase1 (Phospho-Ser23) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Rt E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

ATP1A1 pSer23 antibody

Immunofluorescence analysis of NIH-3T3 cells, using ATP1 alpha1/Na+K+ ATPase1 (Phospho-Ser23) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Rt E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

ATP1A1 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ATPase (Ab-16) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

ATP1A1 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ATPase (Ab-16) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

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