ATP2A2 / SERCA2 antibody

Principal name

ATP2A2 / SERCA2 antibody

Alternative names for ATP2A2 / SERCA2 antibody

Calcium pump 2 ATPase, ATP2B, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, SR Ca(2+)-ATPase 2, Endoplasmic reticulum class 1/2 Ca(2+) ATPase

SwissProt ID

O46674 (Canfa), O55143 (Mouse), P11507 (Rat), P11607 (Pig), P16615 (Human), P20647 (Rabit), Q00779 (Felca), Q03669 (Chick)

Gene ID

488 (ATP2A2), 29693 (Atp2a2), 11938

Available reactivities

Can (Canine), Dros (Drosophila), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Mky (Monkey), Rb (Rabbit)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of ATP2A2 / SERCA2 antibody

Three Ca2+ ATPases have been described in mammalian cells. They are located in the plasma membrane, endoplasmic reticulum or the Golgi apparatus. SERCA pumps are located in both the endoplasmic reticulum and in the Golgi membranes. They are known to transport two Ca2+ molecules per hydrolysis of one ATP. Their structure includes ten transmembrane domains and their main role is to remove cytoplasmic Ca2+ ions in order to promote muscle relaxation. In mammals three genes encode three SERCA pumps. Each transcript undergoes tissue-dependent altertive splicing. SERCA1a and 1b are expressed in adult and neotal skeletal muscle respectively. SERCA2a is also expressed in skeletal muscle, while SERCA2b is ubiquitously expressed. SERCA3 is expressed in a limited number of non-muscle cells. Although all SERCAs are regulated, SERCA2b undergoes extensive regulation at the protein level, such as protein-protein interaction, phosphorylation and glycosylation. SERCA2 catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal domint skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ATP2A2 / SERCA2 antibody

  Anti-ATP2A2 Rabbit Polyclonal Antibody  
Predicted band size: 115 kDa . Positive control: Heart tissue lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ATP2A2 / SERCA2 antibody

  Goat Anti-SERCA2 / ATP2A2 Antibody  
TA326319 (0.1µg/ml) staining of Human (A), Mouse (B) and Rat (C) Heart lysates (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ATP2A2 / SERCA2 antibody

  Rabbit Polyclonal Anti-SERCA2  
Western blot analysis of rat heart membranes (lanes 1 and 5), mouse heart membranes (lanes 2 and 6), rat PC12 pheochromocytoma cell line lysate (lanes 3 and 7) and human Jurkat T cell leukemia cell line lysate (lanes 4 and 8): 1- 4. Anti-SERCA2 antibody, (1:200). 5- 8. Anti-SERCA2 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt ICC/IF, WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

ATP2A2 - human gene knockout kit via CRISPR

ATP2A2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

ATP2A2 - human gene knockout kit via CRISPR

ATP2A2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

ATP2A2 - human gene knockout kit via CRISPR

ATP2A2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

ATP2A2 - human gene knockout kit via CRISPR

ATP2A2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Atp2a2 - mouse gene knockout kit via CRISPR

Atp2a2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Atp2a2 - mouse gene knockout kit via CRISPR

Atp2a2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Atp2a2 - mouse gene knockout kit via CRISPR

Atp2a2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Atp2a2 - mouse gene knockout kit via CRISPR

Atp2a2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ATP2A2 (mGFP-tagged) - Human ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ATP2A2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, ATP2A2 (mGFP-tagged) - Human ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ATP2A2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, ATP2A2 (mGFP-tagged)-Human ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ATP2A2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, ATP2A2 (mGFP-tagged)-Human ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ATP2A2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,040.00
  OriGene Technologies, Inc.

Lenti ORF particles, ATP2A2 (Myc-DDK tagged) - Human ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ATP2A2), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, ATP2A2 (Myc-DDK tagged) - Human ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ATP2A2), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, ATP2A2 (Myc-DDK-tagged)-Human ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ATP2A2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, ATP2A2 (Myc-DDK-tagged)-Human ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ATP2A2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,840.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Atp2a2 (GFP-tagged) - Mouse ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (Atp2a2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Atp2a2 (GFP-tagged) - Mouse ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (Atp2a2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,830.00
  OriGene Technologies, Inc.

Lenti ORF particles, Atp2a2 (Myc-DDK-tagged) - Mouse ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (Atp2a2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Atp2a2 (Myc-DDK-tagged) - Mouse ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (Atp2a2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,650.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Atp2a2 (GFP-tagged ORF) - Rat ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (Atp2a2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Atp2a2 (GFP-tagged ORF) - Rat ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (Atp2a2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,770.00
  OriGene Technologies, Inc.

Lenti ORF particles, Atp2a2 (GFP-tagged ORF) - Rat ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (Atp2a2), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, Atp2a2 (GFP-tagged ORF) - Rat ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (Atp2a2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €2,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, Atp2a2 (Myc-DDK-tagged ORF) - Rat ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (Atp2a2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Atp2a2 (Myc-DDK-tagged ORF) - Rat ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (Atp2a2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,598.00
  OriGene Technologies, Inc.

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