ATP2B2 / PMCA2 antibody

Principal name

ATP2B2 / PMCA2 antibody

Alternative names for ATP2B2 / PMCA2 antibody

Calcium pump 2 ATPase, Plasma membrane calcium-transporting ATPase 2, Plasma membrane calcium ATPase isoform 2, Plasma membrane calcium pump isoform 2

SwissProt ID

P11506 (Rat), Q01814 (Human), Q9R0K7 (Mouse)

Gene ID

491 (ATP2B2), 24215 (Atp2b2), 11941

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB)

Background of ATP2B2 / PMCA2 antibody

The plasma membrane Ca2+ ATPase (PMCA) is a transport protein in the plasma membrane of cells responsible for removing calcium (Ca2+) from the cell. This pump is vital for regulating the amount of Ca2+ within cells. The PMCA and the + calcium exchanger (NCX) are together the main regulators of intracellular Ca2+ concentrations. Since it transports Ca2+ into the extracellular space, the PMCA is also an important regulator of the Ca2+ concentration in the extracellular space. The PMCA belongs to a family of P-type primary ion transport ATPases, and is expressed in a variety of tissues, including the brain. The pump is powered by the hydrolysis of adenosine triphosphate (ATP), with a stoichiometry of one Ca2+ ion removed for each molecule of ATP hydrolyzed. It binds to Ca2+ ions with a high affinity (a Km of 100 to 200 nM) but does not remove Ca2+ at a very fast rate. This is in contrast to the NCX, which has a low affinity and a high capacity. Thus, the PMCA is effective at binding Ca2+ even when its concentration within the cell is very low, so it is suited for maintaining Ca2+ at its normally very low levels. The NCX is better suited for removing large amounts of Ca2+ quickly, as it is needed in neurons after an action potential. Thus the activities of the two types of pump complement each other.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ATP2B2 / PMCA2 antibody

  Rabbit Polyclonal Anti-PMCA2  
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes: 1, 2. Anti-PMCA2 antibody, (1:400). 3, 4. Anti-PMCA2 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €622.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ATP2B2 / PMCA2 (transcript variant 1)

  Recombinant protein of human ATPase, Ca++ transporting, plasma membrane 2 (ATP2B2), transcript variant 1  
ATP2B2 / PMCA2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, ATP2B2 (mGFP-tagged) - Human ATPase, Ca++ transporting, plasma membrane 2 (ATP2B2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, ATP2B2 (mGFP-tagged) - Human ATPase, Ca++ transporting, plasma membrane 2 (ATP2B2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,503.00
  OriGene Technologies, Inc.

Lenti ORF particles, ATP2B2 (mGFP-tagged)-Human ATPase, Ca++ transporting, plasma membrane 2 (ATP2B2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, ATP2B2 (mGFP-tagged)-Human ATPase, Ca++ transporting, plasma membrane 2 (ATP2B2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,431.00
  OriGene Technologies, Inc.

Lenti ORF particles, ATP2B2 (Myc-DDK-tagged)-Human ATPase, Ca++ transporting, plasma membrane 2 (ATP2B2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, ATP2B2 (Myc-DDK-tagged)-Human ATPase, Ca++ transporting, plasma membrane 2 (ATP2B2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,194.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Atp2b2 (GFP-tagged) - Mouse ATPase, Ca++ transporting, plasma membrane 2 (cDNA clone MGC:100113 IMAGE:30621322), 200 uL, >10^7 TU/mL

Lenti ORF particles, Atp2b2 (GFP-tagged) - Mouse ATPase, Ca++ transporting, plasma membrane 2 (cDNA clone MGC:100113 IMAGE:30621322), 200 uL, >10^7 TU/mL  
200 µl / €1,206.00
  OriGene Technologies, Inc.

Lenti ORF particles, Atp2b2 (Myc-DDK-tagged) - Mouse ATPase, Ca++ transporting, plasma membrane 2 (cDNA clone MGC:100113 IMAGE:30621322), 200 uL, >10^7 TU/mL

Lenti ORF particles, Atp2b2 (Myc-DDK-tagged) - Mouse ATPase, Ca++ transporting, plasma membrane 2 (cDNA clone MGC:100113 IMAGE:30621322), 200 uL, >10^7 TU/mL  
200 µl / €1,082.00
  OriGene Technologies, Inc.

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