ATP2B2 / PMCA2 antibody

Principal name

ATP2B2 / PMCA2 antibody

Alternative names for ATP2B2 / PMCA2 antibody

Calcium pump 2 ATPase, Plasma membrane calcium-transporting ATPase 2, Plasma membrane calcium ATPase isoform 2, Plasma membrane calcium pump isoform 2

SwissProt ID

P11506 (Rat), Q01814 (Human), Q9R0K7 (Mouse)

Gene ID

491 (ATP2B2), 24215 (Atp2b2)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of ATP2B2 / PMCA2 antibody

The plasma membrane Ca2+ ATPase (PMCA) is a transport protein in the plasma membrane of cells responsible for removing calcium (Ca2+) from the cell. This pump is vital for regulating the amount of Ca2+ within cells. The PMCA and the + calcium exchanger (NCX) are together the main regulators of intracellular Ca2+ concentrations. Since it transports Ca2+ into the extracellular space, the PMCA is also an important regulator of the Ca2+ concentration in the extracellular space. The PMCA belongs to a family of P-type primary ion transport ATPases, and is expressed in a variety of tissues, including the brain. The pump is powered by the hydrolysis of adenosine triphosphate (ATP), with a stoichiometry of one Ca2+ ion removed for each molecule of ATP hydrolyzed. It binds to Ca2+ ions with a high affinity (a Km of 100 to 200 nM) but does not remove Ca2+ at a very fast rate. This is in contrast to the NCX, which has a low affinity and a high capacity. Thus, the PMCA is effective at binding Ca2+ even when its concentration within the cell is very low, so it is suited for maintaining Ca2+ at its normally very low levels. The NCX is better suited for removing large amounts of Ca2+ quickly, as it is needed in neurons after an action potential. Thus the activities of the two types of pump complement each other.

5 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ATP2B2 / PMCA2 antibody

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes: 1, 2. Anti-PMCA2 antibody, (1:400). 3, 4. Anti-PMCA2 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

ATP2B2 / PMCA2 antibody

Western blot analysis of PMCA2 expression in HEK293T (A); mouse brain (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

ATP2B2 / PMCA2 antibody

Western blot analysis of PMCA2 expression in HEK293T (A); mouse brain (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

ATP2B2 / PMCA2 antibody

Western blot analysis of PMCA2 expression in HEK293T (A); mouse brain (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

ATP2B2 / PMCA2 (transcript variant 1)

ATP2B2 / PMCA2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

5 Item(s)

per page
  • LinkedIn