ATR / FRP1 antibody

Principal name

ATR / FRP1 antibody

Alternative names for ATR / FRP1 antibody

FRAP-related protein 1, Serine/threonine-protein kinase ATR, Ataxia telangiectasia and Rad3-related protein

SwissProt ID

Q13535 (Human), Q9JKK8 (Mouse)

Gene ID

545 (ATR)

Available reactivities

Hu (Human), Ms (Mouse), Hst (Hamster), Bov (Bovine), Xen (Xenopus), Mky (Monkey), Rt (Rat), Can (Canine), Fi (Fish)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of ATR / FRP1 antibody

Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidylinositol kinase (PK)-related kinase which functions in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle. ATR activates checkpoint signaling upon genotoxic stresses, such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. ATR is a member of the DNA-PK kinase family and is closely related to ATM and DNAPK for which DNA stimulates the observed kinase activity. Chromosomal remodeling proteins have also been reported to associate with ATR complexes, including histone deacetylases (HDAC1, HDAC2 and CHD4). ATR is known to phosphorylate BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and TP53/p53 which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. ATR is a nuclear protein, but can also be found in PML nuclear bodies in certain cell types. ATR is recruited to chromatin during Sphase and redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ATR / FRP1 antibody

Western blot using anti-ATR antibody shows detection of ATR in HeLa cell nuclear extract (lane 1). Lane 2 shows negligible staining after pre-incubation of antibody with the immunizing peptide (50 ?g peptide for 1 h at room temperature followed by centrifugation). A 4-8% gradient gel was used for separation. Goat serum was used at 5% for blocking. The arrowhead corresponds to 301 kDa ATR when compared to MW markers (Lane M). The primary antibody was used at a 1:1,400 dilution. Rabbit IgG Aff - Purified Can, Fi, Hu, Mky, Ms, Rt, Xen E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ATR / FRP1 (2545-2645) antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 1E9 Purified Hu E, P
50 µg / €530.00
  Acris Antibodies GmbH

ATR / FRP1 antibody

Western blot analysis of ATR expression in Lu99A (1) and T24 (2) using AM26640AF-N. Mouse IgG1 4D7 Azide Free Hu WB
0.1 mg / €350.00
  Acris Antibodies GmbH

ATR / FRP1 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ATR Antibody (AP08085PU). Rabbit Aff - Purified Hu P
0.1 ml / €270.00
  Acris Antibodies GmbH

ATR / FRP1 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ATR Antibody (AP08085PU). Rabbit Aff - Purified Hu P
50 µl / €230.00
  Acris Antibodies GmbH

ATR / FRP1 antibody

ATR / FRP1 Rabbit Serum Hst, Hu, Ms WB
0.1 ml / €520.00
  Acris Antibodies GmbH

ATR / FRP1 antibody

ATR / FRP1 Rabbit Serum Bov, Hst, Hu, Ms WB
0.1 ml / €530.00
  Acris Antibodies GmbH

ATR / FRP1 antibody

ATR / FRP1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

ATR / FRP1 antibody

Immunofluorescence of monoclonal antibody to ATR on HeLa cell . [antibody concentration 10 ug/ml] Mouse IgG1 3F2 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

ATR / FRP1 antibody

Immunoperoxidase of monoclonal antibody to ATR on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml] Mouse IgG1 1E9 Purified Hu E, P
0.1 mg / €370.00
  Abnova Taiwan Corp.

ATR / FRP1 antibody

Western blotting in normal ( 1 ) and Etoposide stimulated ( 2 ) of HeLa whole cell lysates.
Panel A : Incubated with ATR polyclonal antibody ( Cat # PAB9924 ) at 1 :2000 dilution.
Panel B : Incubated with ATR polyclonal antibody ( Cat # PAB9924 ) and 5 fold excess of immunogen peptide in peptide competition assay. Hu, Mky, Ms, Rt
0.1 mg / €560.00
  Abnova Taiwan Corp.

ATR / FRP1 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ATR polyclonal antibody ( Cat # PAB12228 ). Rabbit Hu P
0.1 mg / €390.00
  Abnova Taiwan Corp.

ATR / FRP1 pSer428 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using ATR (Phospho-Ser428) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P
50 µg / €205.00
  Assay Biotech

ATR / FRP1 pSer428 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using ATR (Phospho-Ser428) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P
0.1 mg / €310.00
  Assay Biotech

ATR / FRP1 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using ATR (Ab-428) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P
50 µg / €205.00
  Assay Biotech

ATR / FRP1 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using ATR (Ab-428) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P
0.1 mg / €310.00
  Assay Biotech

ATR / FRP1 antibody

Western Blot: ATR Antibody (2B5) [NB100-308] - Western Blot analysis of ATR, using NB100-308. Sample: Raji whole cell extracts. Mouse IgG 2B5 Purified Hu ICC/IF, IP, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

ATR / FRP1 (Super Novus Pack) antibody

Western Blot: ATR Antibody Pack 2 vials [NB100-916] - Human ATR detected in HeLa and U205 cell lysates using NB 100-322 Rabbit Aff - Purified Hu, Ms WB
2 vials / €510.00
  Novus Biologicals Inc.

ATR / FRP1 antibody

ATR / FRP1 Rabbit IgG Aff - Purified Hu E, P
0.1 mg / €360.00
  Novus Biologicals Inc.

ATR / FRP1 antibody

ATR / FRP1 Rabbit IgG Aff - Purified Hu E, P
50 µg / €290.00
  Novus Biologicals Inc.

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