Atrial Natriuretic Factor (ANF) antibody

Principal name

Atrial Natriuretic Factor (ANF) antibody

Alternative names for Atrial Natriuretic Factor (ANF) antibody

Atrial Natriuretic Peptide, Prepronatriodilatin, NPPA, ANP, PND

SwissProt ID

O46540 (Sheep), P01160 (Human), P01161 (Rat), P05125 (Mouse), P07499 (Canfa), P07500 (Rabit), P07501 (Bovin), P18908 (Chick), P24259 (Pig), P27104 (Horse), Q9GLD0 (Felca)

Gene ID

4878 (NPPA), 24602 (Nppa), 1114878 (aldR)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine), Fe (Feline), GP (Guinea Pig), Por (Porcine), Mky (Monkey)

Available hosts

Rabbit, Mouse, Sheep, Goat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Radioimmunoassay (R), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of Atrial Natriuretic Factor (ANF) antibody

The family of natriuretic peptides comprise of several 22-53 amino acid petides with vasoadilator and diuretic properties and play a pivotal role in cardiovascular homeostasis. So far we have five natriuretic peptides known ANP, urodilin, ANP, CNP and DNP. The prohormones for ANP, BNP and CNP are encoded by different genes. The arterial natriuretic peptide (ANP) and the brain natriuretic peptide (BNP) are serected as prohormones (Pro-ANP and Pro-BNP) and their levels are significantly increases in non survival cardiacdysfunction patients (1). They are also useful as a laboratory markers for myocardial dysfunction and various other clinical conditions such as pulmonary thrombo embolism, transient tachypnea, sepsis and stroke. The levels of these peptides may also differentiate between survival and non-survival acute sepsis. The Pro ANP is stored in the cells and are released upon stretch from artria into circulation. The rate limiting protease, corin, a trans-membrane serine protease converts Pro-ANP in to ANP for immediate release in to circulation. The release of ANP cuases an increase in cGMP in the cells by acting on 3 types of ANP receptors (ANPA, ANPB and ANPC).
In situ, ANP is phosphorylated by cAMP-dependent Kinase at ser-104 however, only a subpopulation of the ANP molecules are regulated by this mechanism. The pro-ANP gene is a 151 amino acid soluble protein with a low complexity amino terminal region. The proANP (15 kDa) is cleaved by cardiomyocytes to 3kDa active ANP. There is a significant homology in the primary amino acid sequence and of physiological effects of ANP across different species.
The ProANP protein is a approximately 18kDa (151 amino acids) protein.

General readings

1. Hartter E, Khalafpour S, Missbichler A, Hawa G, Woloszczuk W (2000). Enzyme immunoassays for
fragments (epitopes) of human proatrial natriuretic peptides. Clin Chem Lab Med 38:27-32.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Atrial Natriuretic Factor (ANF) (C-term) antibody

TA309531 (0.01µg/ml) staining of Mouse Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Atrial Natriuretic Factor (ANF) antibody

Western blot analysis of extracts of PC-3 cell lines, using NPPA antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Atrial Natriuretic Factor (ANF) (ANP 1-28) antibody

Atrial Natriuretic Factor (ANF) Mouse IgG1 L11-11-D6-B4 Purified Hu E
0.1 mg / €500.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (ANP 1-28) antibody

Atrial Natriuretic Factor (ANF) Mouse IgG1 L11-11-D6-B4 Purified Hu E
10 µg / €180.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (40-55) antibody

Atrial Natriuretic Factor (ANF) Mouse M14/19/F9 Purified Hu E
0.1 mg / €500.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (40-55) antibody

Atrial Natriuretic Factor (ANF) Mouse M14/19/F9 Purified Hu E
10 µg / €180.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (40-55) antibody

Atrial Natriuretic Factor (ANF) Mouse A137/M6/19/B6 Purified Hu E
0.1 mg / €500.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (40-55) antibody

Atrial Natriuretic Factor (ANF) Mouse A137/M6/19/B6 Purified Hu E
10 µg / €180.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (40-55) antibody

Atrial Natriuretic Factor (ANF) Mouse A137/M6/21/D5 Purified Hu E
0.1 mg / €500.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (40-55) antibody

Atrial Natriuretic Factor (ANF) Mouse A137/M6/21/D5 Purified Hu E
10 µg / €180.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (80-93) antibody

Atrial Natriuretic Factor (ANF) Mouse M14/19/H3 Purified Hu E
0.1 mg / €500.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (80-93) antibody

Atrial Natriuretic Factor (ANF) Mouse M14/19/H3 Purified Hu E
10 µg / €180.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (ANP 1-28) antibody

Atrial Natriuretic Factor (ANF) Rabbit Serum Hu E
0.1 ml / €400.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (ANP 1-28) antibody

Atrial Natriuretic Factor (ANF) Rabbit Serum Hu E
20 µl / €160.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (ANP 1-28) antibody

Atrial Natriuretic Factor (ANF) Sheep Serum Hu E, R
0.1 ml / €400.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (ANP 1-28) antibody

Atrial Natriuretic Factor (ANF) Sheep Serum Hu E, R
20 µl / €160.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (ANP 1-28) antibody

Atrial Natriuretic Factor (ANF) Rabbit Serum Rt R
0.1 ml / €440.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (ANP 1-28) antibody

Atrial Natriuretic Factor (ANF) Rabbit Serum Rt R
20 µl / €170.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (1-30) antibody

Atrial Natriuretic Factor (ANF) Sheep Serum Hu E, R
0.1 ml / €440.00
  Acris Antibodies GmbH

Atrial Natriuretic Factor (ANF) (1-30) antibody

Atrial Natriuretic Factor (ANF) Sheep Serum Hu E, R
20 µl / €130.00
  Acris Antibodies GmbH

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