ATXN3L antibody

Principal name

ATXN3L antibody

Alternative names for ATXN3L antibody

Putative ataxin-3-like protein, ATX3L, MJDL, Machado-Joseph disease protein 1-like

Gene ID

92552 (ATXN3L)

Available reactivities

Hu (Human)

Available hosts

Rabbit

Available applications

Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB)

Background of ATXN3L antibody

Defects in ATXN3 are the cause of spinocerebellar ataxia type 3 (SCA3) ; also known as Machado-Joseph disease (MJD). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA3 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. The molecular defect in SCA3 is the a CAG repeat expansion in ATXN3 coding region. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ATXN3L antibody

Immunohistochemistry-Paraffin: ATXN3L Antibody [NBP1-93456] Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

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