Aurora kinase C antibody

Principal name

Aurora kinase C antibody

Alternative names for Aurora kinase C antibody

AURKC, AIE2, AIK3, STK13, Aurora/Ipl1/Eg2 protein 2, Aurora/Ipl1-related kinase 3, Aurora-C, Serine/threonine-protein kinase 13

SwissProt ID

O88445 (Mouse), Q9UQB9 (Human)

Gene ID

6795 (AURKC)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Ze (Zebrafish), African clawed frog, Chk (Chicken), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Frozen Sections (C)

Background of Aurora kinase C antibody

Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases, members of the Ser/Thr protein kinase family, associate with microtubules during chromosome movement and segregation. Aurora kinase C may play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. This protein is localized to centrosome from anaphase to cytokinesis. Expression is limited to testis in normal cells. Elevated expression levels are seen only in a subset of cancer cells such as HepG2, HuH7 and HeLa cells. Aurora-C expression is maximum at M phase. 
Function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Cellular Location: Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis. 
Tissue Location: Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.

General readings

1. Dieterich K et al. The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population. Human molecular genetics 2009 Apr 18 (7): 1301-9.
PMID: 19147683

  1. Quick-Filters:
  2. Highly Validated (3)

Items 1 to 20 of 26 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Aurora kinase A/B/C antibody

HeLa cell cultures were stained with Aurora A/B/C kinase antibody (green). In this image, strong staining in spindle poles was seen in cells at anaphase. This antibody also stains the midbodies between the two daughter cells. Counterstained is our chicken polyclonal antibody against Vimentin, (red). Blue is a DNA stain. Mouse IgG Aff - Purified Bov, Chk, Eq, Hu, Ms, Por, Rt ICC/IF, P, WB
0.1 ml / €380.00
  Neuromics Antibodies

Aurora kinase C antibody

Immunohistochemical staining of paraffin-embedded endometrium tissue within the normal limits using anti-AURKCmouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500554, Dilution 1:50) Mouse IgG1 OTI10A7 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Aurora kinase C antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of breast tissue using anti-AURKC mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500602, Dilution 1:50) Mouse IgG1 OTI2B7 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Aurora kinase C antibody

Immunohistochemistry-Paraffin: IPL-1/STK13/Aurora C Antibody (2B7) [NBP1-47663] - Immunohistochemical staining of paraffin-embedded pancreas tissue using anti-AURKCmouse monoclonal antibody. (Dilution 1:50) Mouse 2B7 Aff - Purified Hu P, WB
0.1 ml / €620.00
  Novus Biologicals Inc.

Aurora kinase C antibody

(1.5ug/ml) staining of Human Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Aurora kinase C antibody

Western blot analysis of extracts from 293 cells, treated with Paclitaxel (1uM, 24hours), using AurB/C (Ab-202/175) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Aurora kinase C (N-term) antibody

The anti-Aurora C Pab (Cat. #TA324889) is used in WB to detect Aurora C in lysates of 293 cells expressing Flag tag (lane 1), Flag-tagged Aurora A (lane 2), Flag-tagged Aurora B (lane 3) or Flag-tagged Aurora C (lane 4). In the IF, staining of HeLa cells expressing GFP-Aurora C is performed at different cellular mitotic stages with the anti-Aurora C Pab (column A), GFP fluorescence (column B), DAPI nuclear staining (column C), and anti-Aurora C merged to DAPI staining (column D). Rabbit Ig Purified Hu E, ICC/IF, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Aurora kinase C (N-term) antibody

The anti-Aurora C Pab (Cat. #TA324890) is used in WB to detect Aurora C in lysates of 293 cells expressing Flag tag (lane 1), Flag-tagged Aurora A (lane 2), Flag-tagged Aurora B (lane 3) or Flag-tagged Aurora C (lane 4). In the IF, staining of HeLa cells expressing GFP-Aurora C is performed at different cellular mitotic stages with the anti-Aurora C Pab (column A), GFP fluorescence (column B), DAPI nuclear staining (column C), and anti-Aurora C merged to DAPI staining (column D). Rabbit Ig Purified Hu E, ICC/IF, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Aurora kinase C antibody

WB Suggested Anti-AURKC Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human Pancreas Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Aurora kinase C antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY AURKC (RC213890, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-AURKC. Mouse IgG1 OTI4F7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Aurora kinase C antibody

Western Blot analysis of AURKC expression in transfected 293T cell line (H00006795-T01) by AURKC MaxPab polyclonal antibody.

Lane 1: AURKC transfected lysate(33.99 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Aurora kinase C antibody

In the immunofluorescence experiment, staining of HeLa cells expressing GFP-AURKC is performed at different cellular mitotic stages with The AURKC polyclonal antibody ( Cat # PAB4510 ) ( column A ) , GFP fluorescence ( column B ) , DAPI nuclear staining ( column C ) , and antiAURKC merged to DAPI staining ( column D ) . Data is kindly provided by Drs . K . Sasai and S . Sen from the University of Texas MD Anderson Cancer Center ( Houston, TX ) . Rabbit Hu E, ICC/IF, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Aurora kinase C antibody

In the immunofluorescence experiment, staining of HeLa cells expressing GFP-AURKC is performed at different cellular mitotic stages with The AURKC polyclonal antibody ( Cat # PAB4511 ) as primary antibody ( column A ) , GFP fluorescence ( column B ) , DAPI nuclear staining ( column C ) , and anti-AURKC merged to DAPI staining ( column D ) . Data is kindly provided by Drs . K . Sasai and S . Sen from the University of Texas MD Anderson Cancer Center ( Houston, TX ) . Rabbit Hu E, ICC/IF, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Aurora kinase C antibody

The AURKC polyclonal antibody ( Cat # PAB4512 ) is used in Western blot to detect AURKC in lysates of 293 cells expressing Flag tag ( lane 1 ) , Flag-tagged AURKA ( lane 2 ) , Flag-tagged AURKB ( lane 3 ) , and Flag-tagged AURKC ( lane 4 ) . Data is kindly provided by Drs . K . Sasai and S . Sen from the University of Texas MD Anderson Cancer Center ( Houston, TX ) . Rabbit Hu E, ICC/IF, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Aurora kinase C antibody

Human Pancreas; WB Suggested Anti-AURKC Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Human Pancreas; AURKC antibody - middle region (ARP53575_P050) in Human Pancreas cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Por, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

Aurora kinase C antibody

Aurora kinase C Goat Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Aurora kinase C antibody

Western Blot: IPL-1/STK13/Aurora C Antibody [NBP1-54994] - This Anti-AURKC antibody was used in Western Blot of Fetal Pancreas   tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

Aurora kinase C antibody

Immunohistochemistry-Paraffin: IPL-1/STK13/Aurora C Antibody [NBP1-90819] Immunohistochemical staining of human liver shows strong granular cytoplasmic positivity in hepatocytes. Rabbit Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Aurora kinase C

Aurora kinase C Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Aurora kinase C

Aurora kinase C Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Items 1 to 20 of 26 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn