AVEN antibody

Principal name

AVEN antibody

Alternative names for AVEN antibody

PDCD12, Cell death regulator Aven, Programmed cell death 12

SwissProt ID

Q9D9K3 (Mouse), Q9NQS1 (Human)

Gene ID

57099 (AVEN)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C)

Background of AVEN antibody

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients. Despite its predicted molecular weight, Aven often migrates at 55 kDa in SDS-PAGE.

General readings

Figueroa B Jr, et al: (2004) Biotechnol Bioeng. 85(6), 589-600.
Cheng EH, et al: (2000) Mol Cell. 6(1), 31-40.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AVEN antibody

Paraffin embedded sections of human breast lobule tissue were incubated with anti-human PDCD12 (1:50) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB) Mouse IgG2a 3G4 Purified Hu, Ms E, P, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

AVEN antibody

Paraffin embedded sections of human breast lobule tissue were incubated with anti-human PDCD12 (1:50) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB) Mouse IgG2a 3G4 Purified Hu, Ms E, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

AVEN (C-term) antibody

Western blot analysis of Aven in Raji cell lysate with Aven antibody at 1 ug/ml in (A) the presence and (B) the absence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AVEN (N-term) antibody

Western blot analysis of Aven in Raji cell lysate with Aven antibody at 1 ug/ml in (A) the presence and (B) the absence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

AVEN antibody

Western blot analysis of extracts from LOVO cells and COS-7 cells, using AVEN antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AVEN antibody

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using AVEN Antibody at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AVEN antibody

Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane 1-2: Raji cells, Hela cells, Primary antibody: AVEN Antibody at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

AVEN antibody

Skin: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

AVEN antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Testis. Rabbit Aff - Purified Hu, Ms, Rt P, WB
25 µg / €470.00
  Acris Antibodies GmbH

AVEN Control Peptide

AVEN
50 µg / €160.00
  Acris Antibodies GmbH

AVEN Control Peptide

AVEN
50 µg / €160.00
  Acris Antibodies GmbH

AVEN antibody

AVEN monoclonal antibody (M08), clone 2B10. Western Blot analysis of AVEN expression in NIH/3T3(Cat # L018V1 ). Mouse IgG2b 2B10 Purified Hu, Ms, Rt E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

AVEN antibody

The extract of mouse kidney ( 50 µg ) was resolved by SDS-PAGE and probed with AVEN monoclonal antibody, clone 3G4 ( Cat # MAB2053 ) ( 1:1000 ). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Mouse IgG2a 3G4 Hu, Ms E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

AVEN antibody

Immunohistochemistry of AVEN in human spleen tissue with AVEN polyclonal antibody ( Cat # PAB13091 ) at 5 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

AVEN antibody

Immunohistochemistry of AVEN in human spleen tissue with AVEN polyclonal antibody ( Cat # PAB13093 ) at 5 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

AVEN antibody

Western blot analysis of extracts from COS7/LOVO cells, using AVEN Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

AVEN antibody

Western blot analysis of extracts from COS7/LOVO cells, using AVEN Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

AVEN antibody

AVEN Mouse IgG2a 3G4 Purified Hu E, P, WB
0.1 ml / €380.00
  Novus Biologicals Inc.

AVEN antibody

Immunohistochemistry-Paraffin: AVEN Antibody [NBP1-76764] - Human spleen tissue with Aven antibody at 5 u/mL. _x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

AVEN antibody

Immunohistochemistry-Paraffin: AVEN Antibody [NBP1-76771] - Human spleen tissue with Aven antibody at 5 u/mL. _x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

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