AXL / UFO antibody

Principal name

AXL / UFO antibody

Alternative names for AXL / UFO antibody

Tyrosine-protein kinase receptor UFO

SwissProt ID

P30530 (Human), Q00993 (Mouse)

Gene ID

558 (AXL), 26362 (Axl)

Available reactivities

Hu (Human), Bov (Bovine), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), ELISA (detection) (E(detection)), Paraffin Sections (P), EPair for Elisa (EPair), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of AXL / UFO antibody

Axl, also known as UFO, Tyro 7 and ARK, is a receptor tyrosine kinase, is involved in cell survival, proliferation, and migration and have sequence homology with other 2 members of the receptor tyrosine kinase family, MER and Tyro3. This tyrosine kinase is activated by the Growth Arrest Gene 6 (GAS 6) that binds and activated the kinase domin of this receptor kinase. Based on sequence homology and secondary structure predictions, AXL putative protein has a tyrosine kinase domain with unique 2 immunoglobulin like domain in the C-terminal end. It also has 2 fibronectin type III domains which are found on proteins such as receptor tyrosine phosphatases, and cell adhesion molecules. The expression of mRNA for this gene was noted in broad spectrum of developing tissues (e.g. subepidermal cells of the skin, mesenchymal cells of the periosteum). AXL expression is also detected in most cell lines and adult tissues except those of the hmatopoietic lineage (1, 2). The receptor Axl is expressed in primary prostate carcinoma and in prostate cancer cell lines as such as PC-3 and DU 145.

Axl expression increases in the neointima of balloon-injured rat carotids due to the oxidative stress which also plays a role in remodeling of injured vessels. Several cancer cell lines express Axl protein including primary prostate carcinoma and in prostate cancer cell lines as such as PC-3 and DU 145, myeloid leukemia. GAS 6 activation of Axl is also invloved in experimental nephritis model and spermatogenesis (3). IN testis, AXL is expressed in sertoli and leydig cell of the mature testis. The receptor tyrosine kinase AXL protein has has at least 2 variants (AXL1, AXL 2) and is a approximately 130 kDa (888 amino acids) protein. The AXL protein has simlar functional domins as its other family members and has a tyrosine kinase domain closer to the C-terminal region and putative phosphorylation sites.

General readings

1. Rescigno J, Mansukhani A, Basilico C. A putative receptor tyrosine kinase with unique structural topology. Oncogene. 1991 Oct;6(10):1909-13.
2. Sainaghi PP, Castello L, Bergamasco L, Galletti M, Bellosta P, Avanzi GC. Gas6 induces proliferation in prostate carcinoma cell lines expressing the
Axl receptor. J Cell Physiol. 2005 Jul;204(1):36-44.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

AXL / UFO antibody

Brain, cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 7E10 Ascites Hu E, ICC/IF, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

AXL / UFO antibody

Western blot analysis using AXL antibody Cat.-No AM06260SU-N against truncated Trx-AXL recombinant protein (Lane 1). Mouse IgG1 1B3A2 Ascites Hu WB
0.1 ml / €340.00
  Acris Antibodies GmbH

AXL / UFO antibody

Confocal Immunofluorescence analysis of methanol-fixed HEK293 cells trasfected with AXL-hIgGFc using AXL antibody Cat.-No AM06326SU-N (green), showing cytoplasmic and membrane localization. Blue: DRAQ5 fluorescent DNA dye. Mouse IgG1 7E10 Ascites Hu E, ICC/IF, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

AXL / UFO (N-term) antibody

Western blot analysis of anti-AXL N-term Pab in SKBR3 cell lysate. AXL (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

AXL / UFO (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

AXL / UFO antibody

Western blot analysis of anti-AXL Antibody in A375 cell line lysates (35ug/lane). AXL(arrow) was detected using the purified Pab Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

AXL / UFO pTyr691 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using AXL (Phospho-Tyr691) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

AXL / UFO pTyr691 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using AXL (Phospho-Tyr691) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

AXL - human gene knockout kit via CRISPR

AXL - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

AXL - human gene knockout kit via CRISPR

AXL - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

AXL - human gene knockout kit via CRISPR

AXL - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

AXL - human gene knockout kit via CRISPR

AXL - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

AXL / UFO (transcript variant 1)

  Recombinant protein of human AXL receptor tyrosine kinase (AXL), transcript variant 1  
AXL / UFO Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

AXL / UFO (C-term DDK/His tag, transcript variant 1)

  Purified recombinant protein of human AXL receptor tyrosine kinase(AXL), transcript variant 1, with C-terminal DDK/His tag, expressed in human cells, 20 µg  
AXL / UFO Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

AXL / UFO (C-term DDK/His tag, transcript variant 2)

  Purified recombinant protein of human AXL receptor tyrosine kinase(AXL), transcript variant 2, with C-terminal DDK/His tag, expressed in human cells, 20 µg  
AXL / UFO Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

ELISA Kits

Catalog No.    

Human AXL ELISA Kit

Human AXL ELISA Kit  
1 kit / €389.00
  OriGene Technologies, Inc.

Mouse AXL ELISA Kit

Mouse AXL ELISA Kit  
1 kit / €389.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

AXL overexpression lysate

AXL overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, AXL (mGFP-tagged) - Human AXL receptor tyrosine kinase (AXL), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, AXL (mGFP-tagged) - Human AXL receptor tyrosine kinase (AXL), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, AXL (mGFP-tagged)-Human AXL receptor tyrosine kinase (AXL), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, AXL (mGFP-tagged)-Human AXL receptor tyrosine kinase (AXL), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,850.00
  OriGene Technologies, Inc.

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