Baboon antibody

Principal name

Baboon antibody

SwissProt ID

A1Z7L9 (Drome)

Gene ID


Available reactivities

Dros (Drosophila), Mky (Monkey), Ms (Mouse)

Available hosts


Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of Baboon antibody

Transmembrane receptor Patched regulates several developmental processes in both invertebrate and vertebrates. In higher vertebrates the patched (Ptc) also acts as tumor suppressor. The patched receptor signaling involves negatively regulating a GPCR, smoothened. The binding Hedgehog ligand to Ptc, removes the negative interaction of Ptc and allows the signaling by smoothened. It has been shown that Ptc D. melanogasater head development. During head morphogenesis in D. melanogaster Ptc positively interacts with smoothened, which leads to stimulation of Activin type 1 receptor Baboon and activation of cell proliferation in the eye-antennal disc (3). The expression of activated Baboon in the Ptc domain in Ptc mutant background completely abolish the head developmental defects. Baboon is a 601 amino acid long (Mr. Wt. 73 kDa) protein with a single transmembrane domain. FabGennix International Inc. has produced epitope specific anti-Baboon antibodies in rabbit. The Anti-Baboon-selective antibodies were generated against a peptide sequence near the C-terminal end of the protein that are unique to Baboon protein. The Baboon-selective antibodies are affinity purified against immobilized antigen based affinity chromatography which yielded epitope-specific antibodies. The Baboon antibodies label a 73-74 kDa protein in D. melanogaster extracts. Anti-Baboon-selective antibodies are also available in affinity-purified form for confocal, Western blotting and immunocytochemical analyses.

General readings

General / background references:Shyamala BV & Bhat KM A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila. Development 129:1839-47 (2002). PubMed PMID: 11934850
Xie T & Spradling AC decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell 94:251-60 (1998). PubMed PMID: 9695953
Singer MA et al. Signaling through both type I DPP receptors is required for anterior-posterior patterning of the entire Drosophila wing. Development 124:79-89 (1997). PubMed PMID: 9006069
Farooqui SM et al. Antibodies against synthetic peptides predicted from the nucleotide sequence of D2 receptor recognize native dopamine receptor protein in rat striatum. J Neurochem 57:1363-9 (1991). PubMed PMID: 1832709

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