BACE1 antibody

Principal name

BACE1 antibody

Alternative names for BACE1 antibody

BACE, KIAA1149, Beta-secretase 1, Memapsin-2, Aspartyl protease 2, ASP2, BACE-1, Beta-site amyloid precursor protein cleaving enzyme 1, Membrane-associated aspartic protease 2, Beta-site APP cleaving enzyme 1

SwissProt ID

P56817 (Human), P56818 (Mouse), P56819 (Rat), Q2HJ40 (Bovin)

Gene ID

23621 (BACE1), 23821 (Bace1), 29392

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), Mam (Mammalia), Bt (Bat), Can (Canine), Eq (Equine), GP (Guinea Pig), Hst (Hamster), Mky (Monkey), Por (Porcine), Rb (Rabbit)

Available hosts

Goat, Rabbit, Mouse

Available applications

Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F), ELISA (detection) (E(detection))

Background of BACE1 antibody

BACE1 is a protease responsible for the proteolytic processing of the amyloid precursor protein (APP). Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BACE1 antibody

  Rabbit Polyclonal Anti-BACE1 Antibody  
WB Suggested Anti-BACE1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

BACE1 (C-term) antibody

  Rabbit Polyclonal BACE Antibody  
Western blot analysis of BACE in human brain tissue lysate in the absence (A) or presence (B) of blocking peptide (2253P) and in mouse 3T3 cell lysate (C) with BACE antibody at 1 ug/mL. Rabbit IgG Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BACE1 antibody

  Rabbit polyclonal anti-BACE antibody  
Immunohistochemistry analysis of paraffin-embedded human brain tissue using BACE antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

BACE1 antibody

  Anti-BACE1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human thyroid and liver cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using BACE1 antibody at dilution 1/15, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

BACE1 antibody

  Rabbit Polyclonal Anti-BACE1 Antibody (Internal)  
Pancreas: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu P
50 µg / €400.00
  OriGene Technologies, Inc.

BACE1 (C-term) antibody

  Rabbit Polyclonal Anti-BACE1 Antibody (C-Terminus)  
Anti-BACE1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bov, Bt, Can, Chk, Elephant, Eq, GP, Hst, Hu, Mky, Ms, Platypus, Por, Rb, Rt P
50 µg / €400.00
  OriGene Technologies, Inc.

BACE1 antibody

  Rabbit Polyclonal Anti-Bace1 Antibody  
WB Suggested Anti-Bace1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Mouse Heart Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

BACE1 antibody

Western blot analysis using BACE (CT) antibody (AP05096PU-N) on Human brain tissue lysate in the absence (Lane 1) and presence (Lane 2) of blocking peptide and in Mouse 3T3 cell lysate (Lane 3). Rabbit IgG Purified Hu, Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

BACE1 antibody

Immunohistochemistry (IHC) analyzes of BACE antibody (Cat.-No.: AP06371PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms ICC/IF, P
0.1 mg / €350.00
  Acris Antibodies GmbH

BACE1 pSer498 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BACE1 antibody

Formalin-Fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BACE1 (N-term) antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with BACE1 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BACE1 pSer498 antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

BACE1 antibody

BACE1 Goat Serum Hu P
0.1 ml / €440.00
  Acris Antibodies GmbH

BACE1 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using BACE (Ab-498) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €230.00
  Assay Biotech

BACE1 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using BACE (Ab-498) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €330.00
  Assay Biotech

BACE1 antibody

Detection of BACE-1 in human cerebellum. Stained with HRP-DAP (brown) and counter-stained with hemtoxylin (blue).  Mouse IgG1 137612 Purified Hu, Ms E, F, P, WB
0.5 mg / €410.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

Bace1 - mouse gene knockout kit via CRISPR

Bace1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Bace1 - mouse gene knockout kit via CRISPR

Bace1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Bace1 - mouse gene knockout kit via CRISPR

Bace1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

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