BACE1 antibody

Principal name

BACE1 antibody

Alternative names for BACE1 antibody

BACE, KIAA1149, Beta-secretase 1, Memapsin-2, Aspartyl protease 2, ASP2, BACE-1, Beta-site amyloid precursor protein cleaving enzyme 1, Membrane-associated aspartic protease 2, Beta-site APP cleaving enzyme 1

SwissProt ID

P56817 (Human), P56818 (Mouse), P56819 (Rat), Q2HJ40 (Bovin)

Gene ID

23621 (BACE1), 23821 (Bace1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bt (Bat), Bov (Bovine), Can (Canine), Chk (Chicken), Eq (Equine), GP (Guinea Pig), Hst (Hamster), Mky (Monkey), Por (Porcine), Rb (Rabbit), Ze (Zebrafish), Mam (Mammalia)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Flow Cytometry (F), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C)

Background of BACE1 antibody

Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer's disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components. Found associated with the presenilins is the transmembrane glycoprotein nicastrin. Nicastrin has been found to bind to the carboxyl-terminus of beta APP and helps to modulate the production of the amyloid beta peptide.
Also found in the neurofibrillary lesions associated with Alzheimer's disease is a protein termed Tau. Tau is a neuronal microtubule-associated protein found predominantly on axons. Tau functions to promote tubulin polymerization and stabilize microtubules. Tau, in its hyperphosphorylated form, is the major constituent of paired helical filaments (PHF), which are the building block of neurofibrillary lesions found in brain tissue of Alzheimer's diseased patients.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BACE1 antibody

WB Suggested Anti-BACE1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human Liver Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

BACE1 antibody

Human Testis; Testis; BACE1 antibody - N-terminal region (ARP46851_P050) in Human Testis cells using Immunohistochemistry Rabbit Aff - Purified Bov, Chk, Hu, Ms, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

BACE1 (C-term) antibody

Western blot analysis of BACE in human brain tissue lysate in the absence (A) or presence (B) of blocking peptide (2253P) and in mouse 3T3 cell lysate (C) with BACE antibody at 1 ug/mL. Rabbit IgG Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BACE1 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue using BACE antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

BACE1 antibody

Predicted cell location: Cytoplasm. Positive control: Human thyroid and liver cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using BACE1 antibody at dilution 1/15, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

BACE1 antibody

Pancreas: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

BACE1 (C-term) antibody

Anti-BACE1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bov, Bt, Can, Chk, Elephant, Eq, GP, Hst, Hu, Mky, Ms, Platypus, Por, Rb, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

BACE1 antibody

WB Suggested Anti-Bace1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Mouse Heart Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

BACE1 antibody

Western blot analysis using BACE (CT) antibody (AP05096PU-N) on Human brain tissue lysate in the absence (Lane 1) and presence (Lane 2) of blocking peptide and in Mouse 3T3 cell lysate (Lane 3). Rabbit IgG Purified Hu, Ms WB
0.1 mg / €370.00
  Acris Antibodies GmbH

BACE1 antibody

Immunohistochemistry (IHC) analyzes of BACE antibody (Cat.-No.: AP06371PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms ICC/IF, P
0.1 mg / €350.00
  Acris Antibodies GmbH

BACE1 pSer498 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BACE1 antibody

Formalin-Fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BACE1 (N-term) antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with BACE1 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BACE1 pSer498 antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

BACE1 Control Peptide

BACE1
50 µg / €160.00
  Acris Antibodies GmbH

BACE1 antibody

BACE1 Goat Serum Hu P
0.1 ml / €440.00
  Acris Antibodies GmbH

BACE1 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between BACE1 and CSNK1D. HeLa cells were stained with anti-BACE1 rabbit purified polyclonal 1:1200 and anti-CSNK1D mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

BACE1 pSer498 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with BACE1 (phospho S498) polyclonal antibody ( Cat # PAB0414 ) which was peroxidase-conjugated to the secondary antibody followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu E, P, WB
0.4 ml / €400.00
  Abnova Taiwan Corp.

BACE1 antibody

Western blot analysis of BACE1 expression in human brain tissue ( lane 1 ) and in NIH/3T3 ( lane 2 ) with BACE1 polyclonal antibody. Rabbit Hu, Ms WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

BACE1 antibody

Immunocytochemistry of BACE1 in NIH/3T3 cells with BACE1 polyclonal antibody ( Cat # PAB9981 ) at 10 µg/ml. Hu, Ms
0.1 mg / €560.00
  Abnova Taiwan Corp.

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