BACE1 antibody

Principal name

BACE1 antibody

Alternative names for BACE1 antibody

BACE, KIAA1149, Beta-secretase 1, Memapsin-2, Aspartyl protease 2, ASP2, BACE-1, Beta-site amyloid precursor protein cleaving enzyme 1, Membrane-associated aspartic protease 2, Beta-site APP cleaving enzyme 1

SwissProt ID

P56817 (Human), P56818 (Mouse), P56819 (Rat), Q2HJ40 (Bovin)

Gene ID

23621 (BACE1), 23821 (Bace1), 29392

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), Mam (Mammalia), Bt (Bat), Can (Canine), Eq (Equine), GP (Guinea Pig), Hst (Hamster), Mky (Monkey), Por (Porcine), Rb (Rabbit)

Available hosts

Goat, Rabbit, Mouse

Available applications

Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F), ELISA (detection) (E(detection))

Background of BACE1 antibody

BACE1 is a protease responsible for the proteolytic processing of the amyloid precursor protein (APP). Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimers disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remnant. This remnant is then processed by another protease termed gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BACE1 antibody

Detection of BACE-1 in human cerebellum. Stained with HRP-DAP (brown) and counter-stained with hemtoxylin (blue).  Mouse IgG1 137612 Purified Hu, Ms E, F, P, WB
0.5 mg / €410.00
  Neuromics Antibodies

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