BACE2 antibody

Principal name

BACE2 antibody

Alternative names for BACE2 antibody

Beta-secretase 2, AEPLC, ALP56, ASP21, Memapsin-1, Aspartic-like protease 56 kDa, Down region aspartic protease, ASP1, Beta-site APP-cleaving enzyme 2, Aspartyl protease 1, Membrane-associated aspartic protease 1, Beta-site APP-cleaving enzyme 2

SwissProt ID

Q6IE75, Q9JL18, Q9Y5Z0 (Human)

Gene ID

25825 (BACE2), 288227

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of BACE2 antibody

Beta-secretase beta-site APP cleaving enzyme 1/2 (BACE1/2), are membrane-bound aspartyl proteases are rate limiting enzymes in the production of amyloid beta peptides, the primary component of senile plaque pathology in Alzheimer’s disease (AD). The beta amyloid peptides are derived from APP by sequential cleavages of beta and gamma-secretases. The beta-site APP cleaving enzyme (BACE) are the major beta seretases in vivo. There are 2 types of BACE, BACE 1 and BACE 2. BACE 2 is located on chromosome 21 and it is speculated that BACE 2 may play a role in AD and Down syndrome (DS) also called Trisomy 21. A characteristic neuropathological feature of the aging brain is deposition of amyloid β protein (Aβ), initially as diffuse plaques, and more significantly as senile plaques in AD. Aβ is derived from processing of APP by two enzymatic activities: β-secretase (β-site APP-cleaving enzyme, BACE) that releases the N-terminus of Aβ from APP, and a presenilin-dependent γ-secretase complex that releases the C-terminus of Aβ from the membrane. BACE 2 cleaves APP at a novel theta site down stream of the alpha site (1). Over-expression of BACE 2 reduced Aβ production in primary neurons derived from Swedish mutant APP transgenic mice (1). The regulatory regions of the BACE gene contain several functional domains but lack the canonical TATA and CAAT boxes. BACE1 gene contains several repetitive elements compared to non in BACE 2 gene. BACE 2 is under several transcriptional regulatory pathways which partially suppress the expression of BACE 2 in normal neuronal cells and exhibit highly regulated tissue-specific gene expression (2). BACE 2 is highly expressed in breast cancer and may be involved in normal and abnormal process of muscle biology (3).
BACE 2 is secreted as a prozymogen requiring the cleavage of its pro sequence during the maturation process. BACE 2 also interacts with neuronal receptor for APP called SorLA and it affect the intracellular transport and processing (3). APP Crystal structure of BACE 2 reveals the general fold of A1 aspartic proteases. The crystal structure of BACE 2 also reveals differences in the S3, S2, S1 active site substrate pocket. These differences will facilitate designing BACE 2 and BACE 1 selective inhibitors. At least 3 subtypes of BACE 2 enzymes are cloned (BACE2A, 2B and 2C), the relative expression of these three subtypes is not known.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BACE2 antibody

BACE2 Rabbit IgG Purified Hu E, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

BACE2 antibody

Immunohistochemistry: BACE1/beta-secretase 1  Antibody [16520002] - Strong cytoplasmic staining was found in most normal cells. Nuclear staining was also found in rare cases. Secreted positivity was found gastro intestinal tract. Malignant cells were weaker stained than normal cells, almost all samples were weak to moderately stained. Additional nuclear staining was found in a few malignant cells.  Image and statement courtesy of the Human Protein Atlas (HPA). Rabbit Hu E, P
50 µg / €400.00
  Novus Biologicals Inc.

BACE2 (N-term) antibody

Western blot analysis of BACE2 in human (A) and mouse (B) heart tissue lysates with BACE2 antibody at 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BACE2 (C-term) antibody

Western blot analysis of BACE2 in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide with BACE2 antibody at 1 ug/ml. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BACE2 antibody

WB Suggested Anti-BACE2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: ACHN cell lysate.BACE2 is supported by BioGPS gene expression data to be expressed in ACHN Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

BACE2 antibody

WB Suggested Anti-BACE2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: PANC1 cell lysate Rabbit IgG Purified Bov, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

BACE2 (44-59) antibody

Western blot analysis using BACE2 (NT) antibody on human (1) and mouse (2) heart tissue lysate Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €370.00
  Acris Antibodies GmbH

BACE2 (496-511) antibody

Western blot analysis using BACE2 (CT) antibody on human heart tissue lysate in the absence (1) and presence (2) of blocking peptide Rabbit IgG Purified Hu WB
0.1 mg / €370.00
  Acris Antibodies GmbH

BACE2 (44-59) antibody

Figure 2. Staining BACE2 in Lung by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

BACE2 control peptide

BACE2 Hu
0.25 mg / €250.00
  Acris Antibodies GmbH

BACE2 (Isoform A/C) (N-term) antibody

BACE2 Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

BACE2 control peptide

BACE2
0.25 mg / €250.00
  Acris Antibodies GmbH

BACE2 (Isoform B) (N-term) antibody

BACE2 Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

BACE2 (Isoform C) (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BACE2 (Center) antibody

The anti-BACE2 Ctr Pab is used in Western blot to detect BACE2 in HL60 cell lysate. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BACE2 (44-59) antibody

Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

BACE2 (C-term) antibody

Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

BACE2 Control Peptide

BACE2
50 µg / €160.00
  Acris Antibodies GmbH

BACE2 Control Peptide

BACE2
50 µg / €160.00
  Acris Antibodies GmbH

BACE2 antibody

BACE2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

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