Bacillus anthracis Edema Factor antibody

Principal name

Bacillus anthracis Edema Factor antibody

Alternative names for Bacillus anthracis Edema Factor antibody

Calmodulin-sensitive adenylate cyclase, cya, ATP pyrophosphate-lyase, Adenylyl cyclase, Anthrax edema toxin adenylate cyclase component, Edema factor, EF

Gene ID

1158701 (cyaA), 3361726 (P40136)

Available reactivities

Bac (Bacteria)

Available hosts


Available applications

Enzyme Immunoassay (E)

Background of Bacillus anthracis Edema Factor antibody

Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF) (1,2 for review). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) (3) and capillary morphogenesis protein 2 (CMG2) (4), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm (5). EF is a calmodulin and Ca++-dependent adenylate cyclase responsible for the edema seen in the disease. It is thought to benefit the B. anthracis bacteria by inhibiting cells of the host immune system (reviewed in 6).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Bacillus anthracis Edema Factor Control Peptide

Bacillus anthracis Edema Factor
50 µg / €160.00
  Acris Antibodies GmbH

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