BAG4 antibody

Principal name

BAG4 antibody

Alternative names for BAG4 antibody

BAG-4, SODD, BAG family molecular chaperone regulator 4, Bcl-2-associated athanogene 4, Silencer of death domains

SwissProt ID

O95429 (Human), Q8CI61 (Mouse)

Gene ID

9530 (BAG4), 67384 (Bag4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Mky (Monkey)

Available hosts

Rabbit, Mouse, Goat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunoprecipitation (IP), Enzyme Immunoassay (E), ELISA (detection) (E(detection))

Background of BAG4 antibody

Several cell surface receptors that are involved in apoptosis contain intracellular death domains and are capable of triggering apoptosis when activated by their respective ligands. Due to presence of these death domains and presence of various stimuli in the serum as well as overexpression leading to receptor oligomerization, which leads to constitutive activation of the apoptotic pathway, it has been extremely difficult to generate permanent cell lines overexpressing specific receptors in culture. However, in normal states, this death domain activity is silenced presumably due to presence of other cellular factors. Recently, a DR3 associated protein has been isolated by yeast two-hybrid interaction assays. This cDNA encoding a 457-amino acid protein has been named as SODD (Silencer of Death Domain). SODD also associates with the intracellular domains of TNF-R1, but not with those of TNF-R2, Fas, DR4, or DR5. SODD overexpression suppressed the TNF induced cell death as well as NF-kB activation. SODD may act as a negative regulatory protein that is normally associated with death domain of TNF-R1 and probably inhibit self-oligomerization properties of death domain and maintain TNF-R1 in an inactive, monomeric state.
SODD (Silencer of Death Domain) is an important regulator of TNF induced apoptotic pathway. It associates with TNF-R1 to prevent constitutive activation of the signaling events downstream. It dissociates from the TNF-R1 after TNF binds TNF-R1 to allow the activation of apoptotic pathway. It is expressed ubiquitously in human tissues.

General readings

Annunziata CM, Kleinberg L, Davidson B, Berner A, Gius D, Tchabo N, Steinberg SM, Kohn EC.
BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian cancer.
Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6585-92
PMID: 18006758

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BAG4 antibody

  Goat Anti-SODD Antibody  
TA305759 (1ug/ml) staining of HEK293 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BAG4 antibody

  Rabbit Polyclonal SODD Antibody  
Western blot analysis of SODD in HeLa (1,3) and THP-1 (2,4) whole cell lysates in the absence (1,2) or presence (3,4) of blocking peptide (Catalog no. 2143P) with SODD antibody at 1:500 dilution. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BAG4 antibody

  Rabbit polyclonal anti-BAG4 antibody  
Western blot analysis of extracts from K562 cells, using BAG4 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

BAG4 antibody

  Rabbit Polyclonal Anti-BAG4 rabbit polyclonal antibody  
BAG4 Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

BAG4 antibody

  Rabbit Polyclonal BAG4 Antibody  
Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in glandular cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only. Rabbit IgG Purified Hu, Rt E, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

BAG4 antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Brain, cerebellum. Rabbit Purified Hu, Ms, Rt ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

BAG4 (C-term) antibody

BAG4 Antibody (C-term) (Cat. #AP50336PU-N) western blot analysis in Hela cell line lysates (35µg/lane).This demonstrates the BAG4 antibody detected the BAG4 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BAG4 (N-term) antibody

Immunocytochemical staining of Hela cells with Rabbit anti SODD (SP1301) Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

BAG4 (N-term) antibody

Immunocytochemical staining of Hela cells with Rabbit anti SODD (SP1301) Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, WB
50 µg / €280.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

BAG4 - human gene knockout kit via CRISPR

BAG4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

BAG4 - human gene knockout kit via CRISPR

BAG4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

BAG4 - human gene knockout kit via CRISPR

BAG4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

BAG4 - human gene knockout kit via CRISPR

BAG4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Bag4 - mouse gene knockout kit via CRISPR

Bag4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Bag4 - mouse gene knockout kit via CRISPR

Bag4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Bag4 - mouse gene knockout kit via CRISPR

Bag4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Bag4 - mouse gene knockout kit via CRISPR

Bag4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

BAG4

  Recombinant protein of human BCL2-associated athanogene 4 (BAG4)  
BAG4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Lysates

Catalog No.    

BAG4 overexpression lysate

BAG4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, BAG4 (mGFP-tagged) - Human BCL2-associated athanogene 4 (BAG4), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, BAG4 (mGFP-tagged) - Human BCL2-associated athanogene 4 (BAG4), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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