BAI1 antibody

Principal name

BAI1 antibody

Alternative names for BAI1 antibody

BAI-1, Brain-specific angiogenesis inhibitor 1

SwissProt ID

O14514 (Human), Q3UHD1 (Mouse)

Gene ID

575 (BAI1), 107831 (Bai1)

Available reactivities

Bov (Bovine), Can (Canine), Hst (Hamster), Hu (Human), Mky (Monkey), Ms (Mouse), Op (Opossum), Prim (Primate), Bear, Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB)

Background of BAI1 antibody

The three members of the brain angiogenesis inhibitor (BaI1-3) are receptors belonging to the adhesion subfamily of G-protein coupled receptor superfamily. Like all members of GPCRs, all three BaIs have seven transmembrane domains, an intracellular C-termil tail and extracellular N-terminus. Like other adhesion members, the N-terminus is quite large. Many domains are localized to the N-terminus; various glycosylations sites are present, there is a GPCR proteolysis site, a putative hormone binding domain and thrombospondin type 1 repeats which regulate the anti-angiogenic activity of thrombospondin-1. The C-termil tail interacts with PDZ-domain proteins. Unique to BaI1 is a proline-rich domain required for interacting with Src homology domains and WW domain proteins. Like most adhesion GPCRs, BaI also undergo proteolysis at the N-terminus at a highly rich cystein domain. Following autocleavage, the N-termil fragment remains associated to the receptor. In BaI1, proteolysis yields a partly secreted 120 kDa. fragment (vasculostatin-120) or a 40 kDa. fragment both having antiangiogenic effects. At the mR level, all BaIs are expressed in fetal and adult human brain. BaI2 is detected in the human heart and skeletal muscle. BaI3 is expressed in the human heart, testis and small intestine. In mouse, both BaI2 and BaI3 are restricted to the brain. These receptors are implicated in various diseases and disorders such as primary glioma, pulmory adenocarcinomas, gastric and colorectal cancers.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BAI1 (N-term) antibody

Brain: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Elephant, Hu, Mky E, P
50 µg / €425.00
  OriGene Technologies GmbH

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