BAP1 antibody

Principal name

BAP1 antibody

Alternative names for BAP1 antibody

BAP-1, KIAA0272, hucep-6, BRCA1-associated protein 1, Cerebral protein 6, Ubiquitin carboxyl-terminal hydrolase BAP1

SwissProt ID

Q92560 (Human), Q99PU7 (Mouse)

Gene ID

8314 (BAP1), 104416 (Bap1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of BAP1 antibody

'BRCA1-associated protein-1,' or BAP1 interacts with the RING finger domain of BRCA1. The N-terminal 240 amino acids of the predicted 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), thiol proteases that catalyze proteolytic processing of ubiquitin. In addition, BAP1 contains an acidic region, a highly charged C-terminal region, and 2 putative nuclear localization signals.. BAP1 and BRCA1 associate in vivo and have overlapping subnuclear localization patterns.1 BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth. Northern blot analysis indicates that BAP1 is expressed as a 4-kb mRNA in all human tissues tested, with A 4.8-kb transcript expressed exclusively in testis. Northern blot analysis and in situ hybridization reveal that BAP1 and BRCA1 are coexpressed during murine breast development and remodeling. The BAP1 gene has been mapped to 3p21.3, a region of loss of heterozygosity for breast cancer as well as frequently deleted in lung carcinomas.1 Intragenic homozygous rearrangements and deletions of BAP1 appear in lung carcinoma cell lines. It has been postulated that BAP1 is a tumor suppressor gene that functions in the BRCA1 growth control pathway.1

General readings

Jensen, D. E.; Proctor, M.; Marquis, S. T.; Gardner, H. P.; Ha, S. I.; Chodosh, L. A.; Ishov, A. M.; Tommerup, N.; Vissing, H.; Sekido, Y.; Minna, J.; Borodovsky, A.; Schultz, D. C.; Wilkinson, K. D.; Maul, G. G.; Barlev, N.; Berger, S. L.; Prendergast, G. C.; Rauscher, F. J., III : BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene 16: 1097-1112, 1998.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BAP1 antibody

  Mouse Monoclonal Antibody against BAP1 (1G8)  
Detection of BAP1 in HeLa WCE  (2ug/ml) Mouse IgG1 1G8 Purified Hu WB
0.1 ml / €416.00
  OriGene Technologies, Inc.

BAP1 antibody

  Rabbit Polyclonal BAP1 Antibody  
ELISA: BAP1 Antibody Rabbit IgG Purified Hu E
50 µg / €409.00
  OriGene Technologies, Inc.

BAP1 antibody

Lane 1: Rat Testicular tissue Lysate
Lane 2: Rat Ovarian tissue Lysate Mouse IgG1 BP-1 Purified Hu ICC/IF, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

BAP1 (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

BAP1 (C-term) antibody

Western Blot analysis using anti-BAP1 Pab (C-term) (Cat.#AP12078PU-N) to detect BAP1 in SK-BR-3 cell lysate. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

BAP1

  Recombinant protein of human BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (BAP1)  
BAP1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €438.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, BAP1 (mGFP-tagged) - Human BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (BAP1), 200 uL, >10^7 TU/mL

Lenti ORF particles, BAP1 (mGFP-tagged) - Human BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (BAP1), 200 uL, >10^7 TU/mL  
200 µl / €1,082.00
  OriGene Technologies, Inc.

Lenti ORF particles, BAP1 (Myc-DDK tagged) - Human BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (BAP1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, BAP1 (Myc-DDK tagged) - Human BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (BAP1) , 200 uL, >10^7 TU/mL  
200 µl / €969.00
  OriGene Technologies, Inc.

8 Item(s)

per page
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