Bassoon antibody

Principal name

Bassoon antibody

Alternative names for Bassoon antibody

BSN, KIAA0434, ZNF231, Zinc finger protein 231

SwissProt ID

O88737 (Mouse), O88778 (Rat), Q9UPA5 (Human)

Gene ID

8927 (BSN)

Available reactivities

Ms (Mouse), Rt (Rat), Hu (Human)

Available hosts

Mouse, Rabbit, Goat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Bassoon antibody

Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle (1-3). Bassoon does not belong to any known protein families. It has been found in rat and mouse with sequence identity of the two proteins at 96% (1). The human BASSOON gene has recently been cloned and localized (3). Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains (1). The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntingtin, abnormal amplification of this region can cause late-onset neurodegeneration (1,3). Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to colocalize with GABA (A) and glutamate (GluR1) receptors (2). Another presynaptic protein, Piccolo (4) was found to colocalize with Bassoon in cultured hippocampal neurons (1). These observations suggested that they serve specific functions at synaptic junctions and may be involved in organization of the cytoskeleton at the site of neurotransmitter release (1).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Bassoon antibody

Western blot analysis of Bassoon in mouse and rat brain lysate using a 1:1000 dilution of the antibody Rabbit Purified Hu, Ms ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

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