Bax antibody

Principal name

Bax antibody

Alternative names for Bax antibody

Apoptosis regulator BAX, BCL2L4, Bcl2-L-4, Bcl-2-like protein 4, BCL2-associated X protein

SwissProt ID

O02703 (Bovin), Q07812 (Human), Q07813 (Mouse), Q63690 (Rat)

Gene ID

581 (BAX), 5644 (PRSS1), 12028 (Bax)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Rb (Rabbit), Bov (Bovine), Can (Canine), Fe (Feline), Mky (Monkey), Por (Porcine)

Available hosts

Rabbit, Mouse, Sheep

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Flow Cytometry (F), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP)

Background of Bax antibody

The human protein Bax sits at a critical regulatory junction of apoptosis, or programmed cell death. Activated Bax changes conformation, inserts into the MOM (Mitochondrial Outer Membrane), oligomerizes, and induces MOM permeabilization, causing the release of cytochrome c, which effectively commits the cell to die. (Ma J et al., 2012). Mechanisms of membrane perforation include formation of hetero-oligomeric complexes of Bax with other pro-apoptotic proteins such as Bak, or formation of lipidic pores physically aided by mitochondrial membrane-inserted proteins (Garg P et al., 2012). Connexins play important roles in many physiological and pathological processes. In the context of apoptosis, Cx43 translocated to the mitochondria, where it interacted with Bax to initiate the mitochondrial apoptotic pathway. The 241-382 aa region of Cx43 was required for interaction with Bax. Furthermore, this region was responsible for permeabilizing mitochondrial membrane potential. Recent studies elucidate a novel mechanism of the Cx43-mediated regulation of apoptosis in pancreatic cancer (Sun Y et al., 2012). 
Bax acts as a biomarker that exhibited a difference in sub-cellular localization between normal OCSE (Oral Cavity Squamous Epithelium) and OSCC (Oral Cavity Squamous Cell Carcinoma) and was also the only apoptotic protein significantly associated with prognosis. The translocation of Bax from the nucleus to the cytoplasm in OSCC is consistent with increased Bax function at the mitochondria, leading to improved sensitivity to radiotherapy-induced apoptosis in tumours with elevated Bax expression. Bax antibody can be used to study the intracellular redistribution of Bax protein upon induction of apoptosis and its unique subcellular localization. This product can also be used in immunoblot analysis to estimate variations in the expression of specific proteins involved in apoptosis signaling (Bose P et al., 2012).

General readings

1. Dinh C  et al. Short Interfering RNA against Bax Attenuates TNFa-Induced Ototoxicity in Rat Organ of Corti Explants. Otolaryngol Head Neck Surg 148:834-40 (2013). ICC/IF ; Rat . 
2. Monsalve DM  et al. Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression. Cell Death Dis 4:e513 (2013). Human . 

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Bax (N-term) antibody

Hela cell extract was resolved by electrophoresis, transferred to nitrocellulose, and probed with rabbit anti-Bax polyclonal antibody. Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence system. Rabbit IgG Purified Hu, Ms, Rt IP, P, WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

Bax (3-16) antibody

Formalin-Fixed, Paraffin-Embedded Hodgkin's lymphoma stained with Bax Antibody Cat.-No AM32861PU (Clone 2D2). Mouse IgG1 2D2 Purified Hu, Mky C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Bax (3-16) antibody

Formalin-Fixed, Paraffin-Embedded Hodgkin's lymphoma stained with Bax Antibody Cat.-No AM32861PU (Clone 2D2). Mouse IgG1 2D2 Purified Hu, Mky C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Bax (3-16) antibody

Formalin-Fixed, Paraffin-Embedded Hodgkin's lymphoma stained with Bax Antibody Cat.-No AM32861PU (Clone 2D2). Mouse IgG1 2D2 Purified Hu, Mky C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Bax (N-term) antibody

Hela cell extract was resolved by electrophoresis, transferred to nitrocellulose, and probed with rabbit anti-Bax polyclonal antibody. Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence system. Rabbit IgG Purified Hu, Ms, Rt IP, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

Bax antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-BAX Rabbit Polyclonal antibody. (TA590174) Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bax antibody

Human kidney; BAX antibody - N-terminal region (AVARP02020_T100) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

Bax (N-term) antibody

Western blot analysis of Bax protein in Mouse brain extract (A), Rat brain extract (B), HEK 293 cells (C). 200 μg of total protein loaded per well. GST-fusion recombinant Human Bax protein was tested under the same conditions at the concentrations of 100ng (D), 200ng (E), and 500ng (F). Rabbit G26-R Aff - Purified Hu, Ms, Rt C, E, ICC/IF, IP, P, WB
0.1 ml / €460.00
  DB Biotech, spol. s r.o.

Sample sizes available

Bax (N-term) antibody

Western blot analysis of Bax protein in Mouse brain extract (A), Rat brain extract (B), HEK 293 cells (C). 200 μg of total protein loaded per well. GST-fusion recombinant Human Bax protein was tested under the same conditions at the concentrations of 100ng (D), 200ng (E), and 500ng (F). Rabbit G26-R Aff - Purified Hu, Ms, Rt C, E, ICC/IF, IP, P, WB
50 µl / €310.00
  DB Biotech, spol. s r.o.

Sample sizes available

Bax antibody

Paraffin Sections of human normal breast tissue stained with anti-Bax Antibody Cat.-No AM11090PU (Clone SP47). Rabbit SP47 Purified Hu F, P
0.5 ml / €460.00
  Acris Antibodies GmbH

Bax antibody

Paraffin Sections of human normal breast tissue stained with anti-Bax Antibody Cat.-No AM11090PU (Clone SP47). Rabbit SP47 Purified Hu F, P
1 ml / €680.00
  Acris Antibodies GmbH

Bax antibody

Paraffin Sections of human normal breast tissue stained with anti-Bax Antibody Cat.-No AM11090PU (Clone SP47). Rabbit SP47 Purified Hu F, P
0.1 ml / €290.00
  Acris Antibodies GmbH

Bax antibody

Formalin-paraffin Hodgkin's lymphoma stained with Bax Antibody Cat.-No AM50160PU (Clone SPM336). Mouse IgG1 SPM336 Purified Hu, Mky F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Bax antibody

Formalin-paraffin Hodgkin's lymphoma stained with Bax Antibody Cat.-No AM50160PU (Clone SPM336). Mouse IgG1 SPM336 Purified Hu, Mky F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Bax antibody

Formalin-paraffin Hodgkin's lymphoma stained with Bax Antibody Cat.-No AM50160PU (Clone SPM336). Mouse IgG1 SPM336 Purified Hu, Mky F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Bax antibody

Normal breast stained with Anti-Bax antibody Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

Bax antibody

Normal breast stained with Anti-Bax antibody Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

Bax antibody

Normal breast stained with Anti-Bax antibody Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

Bax (N-term) antibody

Western blot analysis of Bax in HL-60 cell lysates with Bax antibody at (A) 1, (B) 2, and (C) 4 ug/mL. Rabbit IgG Purified Hu E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bax antibody

Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using BAX antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

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