BBS4 antibody

Principal name

BBS4 antibody

Alternative names for BBS4 antibody

Bardet-Biedl syndrome 4 protein

SwissProt ID

Q1JQ97 (Bovin), Q8C1Z7 (Mouse), Q96RK4 (Human)

Gene ID

585 (BBS4), 102774 (Bbs4)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Por (Porcine), Bov (Bovine), Rt (Rat), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Rabbit, Goat

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP)

Background of BBS4 antibody

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome.

2 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BBS4 (33-46) antibody

AP23221PU-N BBS4 antibody staining of Human Testis lysate at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Por E, WB
0.1 mg / €350.00
  OriGene Technologies GmbH

BBS4 (125-139) antibody

  Goat Anti-BBS4 (aa 125-139) Antibody  
(1ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

2 Item(s)

per page
  • LinkedIn