BCAR1 / CRKAS antibody

Principal name

BCAR1 / CRKAS antibody

Alternative names for BCAR1 / CRKAS antibody

p130cas, CASS1, Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, p130cas, Cas scaffolding protein family member 1

SwissProt ID

P56945 (Human), Q61140 (Mouse), Q63767 (Rat)

Gene ID

9564 (BCAR1), 25414 (Bcar1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), Bov (Bovine), Can (Canine), Mky (Monkey)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F)

Background of BCAR1 / CRKAS antibody

p130 represents one of several known substrates for v-Crk encoded p47. p130 Cas (for Crk-associated substrate) exhibits a high level of tyrosine phosphorylation and is tightly associated with v-Crk, suggesting a role in v-Crk-mediated cell signaling. The molecular cloning of p130 Cas has shown it to represent a novel SH3 containing signaling molecule with a cluster of multiple putative SH2-binding motifs for v-Crk. By immunoprecipitation analysis, p130 Cas has been shown to be highly phosphorylated at tyrosine residues subsequent to either v-Src p60 or v-Crk-mediated transformation and to form stable complexes with both of these transforming proteins. p130 Cas behaves as an extremely potent substrate for protein tyrosine kinases and has been reported to relocate from the cytoplasm to cell membrane upon tyrosine phosphorylation. One proposed model is that the SH2 domain of v-Crk functions to activate c-Src kinase, which in turn phosphorylates p130 Cas.

General readings

Konstantinovsky,S, et al. (2012) Clin. Exp. Metastasis 29 (6), 527-540
Huang,W., et al. (2012) PLoS ONE 7 (4), E36124

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BCAR1 / CRKAS antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-BCAR1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502536) Mouse IgG1 OTI3A11 Purified Can, Hu, Mky, Ms, Rt F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

BCAR1 / CRKAS antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-BCAR1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502613) Mouse IgG1 OTI1A9 Purified Can, Hu, Mky, Ms, Rt F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BCAR1 / CRKAS antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-BCAR1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502614) Mouse IgG1 OTI3A5 Purified Can, Hu, Mky, Ms, Rt F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BCAR1 / CRKAS antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-BCAR1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502663) Mouse IgG1 OTI1B1 Purified Can, Hu, Mky, Rt F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

BCAR1 / CRKAS antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-BCAR1 rabbit polyclonal antibody. (TA590531) Rabbit IgG Purified Hu E, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

BCAR1 / CRKAS antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using p130 Cas antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

BCAR1 / CRKAS antibody

Western blot analysis of extracts from NIH/3T3 cells, using p130 Cas (Ab-410) antibody (#TA312726).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

BCAR1 / CRKAS antibody

Anti-BCAR1 (1ug/ml) staining of MCF7 (A) and Human Breast cancer (B) lysates (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BCAR1 / CRKAS antibody

Western blot analysis of p130 Cas expression in NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

BCAR1 / CRKAS antibody

Western blot analysis on NIH-3T3 cell lysate using p130 Cas Antibody Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

BCAR1 / CRKAS antibody

Western blot analysis of p130 Cas expression in NIH-3T3 whole cell lysates, the lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

BCAR1 / CRKAS antibody

Immunohistochemistry (IHC) analyzes of p130 Cas antibody (Cat.-No.: AP06404PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

BCAR1 / CRKAS antibody

Immunohistochemistry analyzes of p130 Cas antibody (AP20260PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

BCAR1 / CRKAS pTyr410 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using p130 Cas (Phospho-Tyr410) antibody AP55694PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

BCAR1 / CRKAS pTyr410 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using p130 Cas (Phospho-Tyr410) antibody AP55694PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µl / €270.00
  Acris Antibodies GmbH

BCAR1 / CRKAS antibody

Western Blot analysis of BCAR1 expression in transfected 293T cell line (H00009564-T01) by BCAR1 MaxPab polyclonal antibody.

Lane 1: BCAR1 transfected lysate(95.7 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

BCAR1 / CRKAS antibody

Western Blot analysis of BCAR1 expression in transfected 293T cell line (H00009564-T01) by BCAR1 MaxPab polyclonal antibody.

Lane 1: BCAR1 transfected lysate(95.7 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

BCAR1 / CRKAS antibody

Western Blot analysis of BCAR1 expression in transfected 293T cell line (H00009564-T01) by BCAR1 MaxPab polyclonal antibody.

Lane 1: BCAR1 transfected lysate(93.40 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

BCAR1 / CRKAS antibody

BCAR1 / CRKAS Mouse IgG1 M144 Chk, Hu, Ms, Rt E, ICC/IF, IP, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

BCAR1 / CRKAS antibody

BCAR1 / CRKAS Rabbit Hu, Ms, Rt E, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

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