BCAR3 / SH2D3B antibody

Principal name

BCAR3 / SH2D3B antibody

Alternative names for BCAR3 / SH2D3B antibody

NSP2, Breast cancer anti-estrogen resistance protein 3, SH2 domain-containing protein 3B, Novel SH2-containing protein 2

SwissProt ID

O75815 (Human), Q58DL5 (Bovin), Q9QZK2 (Mouse)

Gene ID

8412 (BCAR3), 29815 (Bcar3)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Por (Porcine), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of BCAR3 / SH2D3B antibody

In breast cancer, the antiestrogen tamoxifen has been prescribed for both primary treatment and the treatment of advanced metastatic disease. Although the drug induces remission in most patients with estrogen receptor-positive disease, all patients eventually develop resistance. van Agthoven et al. (1998) applied an insertiol mutagenesis strategy to a breast cancer cell line. Infected cells were subjected to tamoxifen selection, and the resistant clones were screened for a common integration site linked with antiestrogen resistance. By screening a human testis cD library with the integration site-specific probe, they obtained a cD encoding BCAR3 (breast cancer antiestrogen resistance 3). The deduced 825 amino acid BCAR3 protein contains a putative Src homology 2 (SH2) domain and sequences homologous to yeast CDC48. Northern blot alysis detected abundant expression of a 3.4kb BCAR3 transcript in heart, placenta, skeletal muscle, spleen, prostate, testis, ovary, small intestine, colon, fetal kidney, and several cancer cell lines, but not in nonmalignt breast tissue; a 6kb BCAR3 transcript was also detected in skeletal muscle and heart.

General readings

van Agthoven T, van Agthoven TL, Dekker A, et al. Identification of BCAR3 by a random search for genes involved in antiestrogen resistnace of human breast cancer cells. EMBO J. 1998; 17:2799-808.

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Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  


  Recombinant protein of human breast cancer anti-estrogen resistance 3 (BCAR3)  
BCAR3 / SH2D3B Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €748.00
  OriGene Technologies, Inc.

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