BCCIP / TOK1 antibody

Principal name

BCCIP / TOK1 antibody

Alternative names for BCCIP / TOK1 antibody

Protein TOK-1, BRCA2 and CDKN1A-interacting protein, P21- and CDK-associated protein 1

SwissProt ID

Q2NL37 (Bovin), Q9CWI3 (Mouse), Q9P287 (Human)

Gene ID

56647 (BCCIP)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Immunoprecipitation (IP)

Background of BCCIP / TOK1 antibody

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]. Transcript Variant: This variant (B) is alternatively spliced at the 3' end compared to transcript variant A. It encodes an isoform (BCCIPbeta) which has the same 258 N-terminal aa, but a different C-terminus compared to isoform BCCIPalpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Luedeke,M., et al. (2009) Cancer Epidemiol. Biomarkers Prev. 18 (11), 3030-3035Fan,J., et al. (2009) Cell Cycle 8 (18), 3019-3024

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

BCCIP / TOK1 antibody

BCCIP antibody detects BCCIP protein at nucleus on U373 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded U373 xenograft. BCCIP antibody (TA308557) dilution: 1:500. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

BCCIP / TOK1 antibody

Western blot analysis of extracts from JurKat cells, using BCCIP Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

BCCIP / TOK1 antibody

BCCIP / TOK1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

BCCIP / TOK1 antibody

Immunofluorescence of purified MaxPab antibody to BCCIP on HeLa cell. [antibody concentration 10 ug/ml] Mouse Serum Hu E(detection), ICC/IF, WB
50 µl / €370.00
  Abnova Taiwan Corp.

BCCIP / TOK1 antibody

Immunofluorescence of purified MaxPab antibody to BCCIP on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

BCCIP / TOK1 antibody

Immunofluorescence of purified MaxPab antibody to BCCIP on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

BCCIP / TOK1 antibody

Western Blot and Immunoprecipitation: BCCIP Antibody[NBP1-22993]-  Whole cell lysate from HeLa and 293T cells. BCCIP was also immunoprecipitated by rabbit anti-BCCIP antibody NBP1-22994. Rabbit IgG Aff - Purified Hu ICC/IF, IP, P, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

BCCIP / TOK1 antibody

Western Blot: BCCIP Antibody [NBP1-22994]-Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-BCCIP antibody used for IP at 3 mcg/mg lysate. BCCIP was also immunoprecipitated by rabbit anti- BCCIP antibody NBP1-22993, which recognizes an upstream epitope. Rabbit IgG Aff - Purified Hu IP, P
0.1 mg / €440.00
  Novus Biologicals Inc.

BCCIP / TOK1 antibody

Immunofluorescence: BCCIP Antibody [NBP1-31319] - Immunofluorescence analysis of HeLa, using BCCIP antibody at 1:200 dilution. Rabbit IgG Hu ICC/IF, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

BCCIP / TOK1

BCCIP / TOK1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

BCCIP / TOK1 (1-314, His-tag)

BCCIP / TOK1 Human Purified > 90 % by SDS - PAGE E. coli
0.25 mg / €730.00
  Acris Antibodies GmbH

BCCIP / TOK1 (1-314, His-tag)

BCCIP / TOK1 Human Purified > 90 % by SDS - PAGE E. coli
50 µg / €300.00
  Acris Antibodies GmbH

BCCIP / TOK1

BCCIP / TOK1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

BCCIP / TOK1

BCCIP / TOK1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

BCCIP / TOK1

BCCIP / TOK1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

BCCIP / TOK1

BCCIP / TOK1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

BCCIP / TOK1 Lysate(Denatured)

BCCIP / TOK1 Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

BCCIP / TOK1 Lysate(Denatured)

BCCIP / TOK1 Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

Lysates (Overexpressed)

Catalog No.    

BCCIP overexpression lysate

BCCIP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

BCCIP overexpression lysate

BCCIP overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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