Bcl-10 antibody

Principal name

Bcl-10 antibody

Alternative names for Bcl-10 antibody

BCL10, CIPER, CLAP, cCARMEN, mE10, c-E10, hCLAP, B-cell CLL/lymphoma 10, CED-3/ICH-1 prodomain homologous E10-like regulator, CARD-containing molecule enhancing NF-kappa-B, Cellular homolog of vCARMEN, Mammalian CARD-containing adapter molecule E10, Cellular-E10, CARD-like apoptotic protein

SwissProt ID

O95999 (Human), Q9QYN5 (Rat), Q9Z0H7 (Mouse)

Gene ID

8915 (BCL10)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine)

Available hosts

Mouse, Rabbit, Rat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Flow Cytometry (F), Immunoprecipitation (IP)

Background of Bcl-10 antibody

Bcl10/CIPER/CLAP/mE10 is a widely expressed CARD (caspase recruitment domain) containing protein shown to induce apoptosis and activate NF-?B. The CARD domain mediates self-oligomerization, interactions with other CARD proteins and is necessary for NF-?B activation, although the precise mechanism which Bcl10 regulates these processes is not fully understood. The discovery of Bcl10 came from observations of the chromosomal translocation t(1;14)(p22;q32) from B cell lymphomas of the mucosa-associated lymphoid tissue (MALT). This translocation results in deregulated expression of a truncated form of Bcl10 which lacks apoptotic activity and enhances transformation. Studies from Bcl10 deficient mice demonstrate that Bcl10 is essential for the activation of NF-?B by T- and B-cell receptors. One third of Bcl10 deficient mice developed lethal exencephaly. Surviving mice were uffected by various apoptotic stimuli, but were severely immunodeficient and defective in antigen receptor-induced NF-?Bactiviation. PKC or T-cell receptor sigling results in a downregulation of Bcl10 protein levels, attenuating both NF-?B activation and cellular proliferation and also provides a negative feedback regulation of the NF-?B sigling to T cell sigling.

General readings

General / background references:Ye H et al. BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma. Am J Pathol 157:1147-54 (2000). PubMed PMID: 11021819
Du MQ et al. BCL10 gene mutation in lymphoma. Blood 95:3885-90 (2000). PubMed PMID: 10845924
Willis TG et al. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell 96:35-45 (1999). PubMed PMID: 9989495

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Bcl-10 antibody

Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-BCL10  mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501237, Dilution 1:50) Mouse IgG1 OTI4A8 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Bcl-10 antibody

Anti-BCL10 mouse monoclonal antibody (TA502233) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY BCL10(RC208752). Mouse IgG1 OTI6A4 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Bcl-10 antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-BCL10 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA800451) Mouse IgG1 OTI6A8 Purified Can, Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Bcl-10 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma (A) and liver carcinoma (B), showing cytoplasmic localization using BCL10 antibody Cat.-No AM06073PU-N with DAB staining. Mouse IgG1 4F8 Purified Hu, Ms E, ICC/IF, P, WB
0.1 ml / €360.00
  Acris Antibodies GmbH

Bcl-10 (N-term) antibody

BCL10 antibody (N-term) (Cat. #AP50354PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of the BCL10 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms F, ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Bcl-10 antibody

Immunohistochemistry-Paraffin: Bcl10 Antibody (4F8) [NBP1-51524] -  Immunohistochemical analysis of paraffin-embedded human breast carcinoma (A) and liver carcinoma (B), showing cytoplasmic localization using BCL10 mouse mAb with DAB staining. Mouse IgG1 4F8 Aff - Purified Hu, Ms E, F, ICC/IF, P, WB
0.1 mg / €380.00
  Novus Biologicals Inc.

Bcl-10 antibody

Human MALT B-Cell Lymphoma stained with anti-BCL-10 Antibody Cat.-No AM32440PU (Clone SP153). Rabbit IgG SP153 Purified Hu F, P
0.5 ml / €520.00
  Acris Antibodies GmbH

Bcl-10 antibody

Human MALT B-Cell Lymphoma stained with anti-BCL-10 Antibody Cat.-No AM32440PU (Clone SP153). Rabbit IgG SP153 Purified Hu F, P
1 ml / €730.00
  Acris Antibodies GmbH

Bcl-10 antibody

Human MALT B-Cell Lymphoma stained with anti-BCL-10 Antibody Cat.-No AM32440PU (Clone SP153). Rabbit IgG SP153 Purified Hu F, P
0.1 ml / €300.00
  Acris Antibodies GmbH

Bcl-10 (122-168) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with Bcl-10 Antibody Cat.-No AM32814PU (Clone BL10/411). Mouse IgG1 BL10/411 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Bcl-10 (122-168) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with Bcl-10 Antibody Cat.-No AM32814PU (Clone BL10/411). Mouse IgG1 BL10/411 Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Bcl-10 (122-168) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with Bcl-10 Antibody Cat.-No AM32814PU (Clone BL10/411). Mouse IgG1 BL10/411 Purified Hu C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Bcl-10 (122-168) antibody

Formalin-Paraffin Human tonsil stained with Bcl-10 Antibody Cat.-No AM33259PU (Clone SPM520). Mouse IgG1 SPM520 Purified Hu C, F, ICC/IF, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Bcl-10 (122-168) antibody

Formalin-Paraffin Human tonsil stained with Bcl-10 Antibody Cat.-No AM33259PU (Clone SPM520). Mouse IgG1 SPM520 Purified Hu C, F, ICC/IF, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Bcl-10 (122-168) antibody

Formalin-Paraffin Human tonsil stained with Bcl-10 Antibody Cat.-No AM33259PU (Clone SPM520). Mouse IgG1 SPM520 Purified Hu C, F, ICC/IF, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Bcl-10 antibody

AP21306PU BCL10 antibody staining of Human Tonsil. Rabbit IgG Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

Bcl-10 antibody

AP21306PU BCL10 antibody staining of Human Tonsil. Rabbit IgG Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

Bcl-10 antibody

AP21306PU BCL10 antibody staining of Human Tonsil. Rabbit IgG Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

Bcl-10 antibody

Western blot analysis of Bcl-10 in Raji whole cell lysate in the absence (A) or presence (B) of peptide (2161P) with Bcl-10 antibody at 1:500 dilution. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-10 antibody

Western blot analysis of ovary cell and lung cell lysate using BCL10 antibody. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

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