Bcl-11A antibody

Principal name

Bcl-11A antibody

Alternative names for Bcl-11A antibody

BCL11A, CTIP1, EVI9, KIAA1809, B-cell lymphoma/leukemia 11A, B-cell CLL/lymphoma 11A, COUP-TF-interacting protein 1, Ecotropic viral integration site 9 protein homolog

SwissProt ID

D3ZSY3, Q9H165 (Human), Q9QYE3 (Mouse)

Gene ID

53335 (BCL11A), 305589

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Ze (Zebrafish), African clawed frog, Eq (Equine), Por (Porcine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of Bcl-11A antibody

We know how important it is to your research to have access to antibodies specific for your model. As it is often impossible to know which antibody will work best for a specific sample and application, we now offer SuperNovus Packs. These packs include different antibodies to the same protein to give you the ability to decide for yourself. The SuperNovus Packs are all offered at a discount price compared to purchasing each antibody individually. The B cell leukemia 11A protein (BCL11A/Evi9/CTIP1) has been implicated in hematopoietic cell development and malignancies. BCL11A is a transcriptional repressor that binds directly to a GC-rich motif and is also recruited to a promoter template via interaction with the orphan nuclear receptor, chicken ovalbumin upstream promoter transcription factor II. In both cases, BCL11A-mediated transcriptional repression is only minimally reversed by trichostatin A, suggesting the possible lack of involvement of class I or II histone deacetylases. Nonetheless, chromatin immunoprecipitation assays revealed that expression of BCL11A in mammalian cells resulted in deacetylation of histones H3 and/or H4 that were associated with the promoter region of a reporter gene. BCL11A mediated transcriptional repression, as well as deacetylation of histone H3/H4 in BCL11A-transfected cells, was partially reversed by nicotinamide, an inhibitor of class III histone deacetylases such as SIRT1. SIRT1 was found to interact directly with BCL11A and was recruited to the promoter template in a BCL11A-dependent manner leading to transcriptional repression. These findings indicate a role for SIRT1 in transcriptional repression mediated by BCL11A in mammalian cells.

General readings

Uda,M., (2008) Proc. Natl. Acad. Sci. U.S.A. 105 (5), 1620-1625

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Bcl-11A antibody

Western blot analysis of extracts of various cell lines, using BCL11A antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-11A antibody

WB Suggested Anti-BCL11A Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Human heart Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Bcl-11A antibody

Host: Rabbit; Target Name: Bcl11a; Sample Tissue: Rat Spleen lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Bcl-11A antibody

WB Suggested Anti-BCL11A Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: PANC1 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Bcl-11A antibody

ELISA: Ctip1 Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-11A antibody

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 3D9 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Bcl-11A (C-term) antibody

Western blot analysis of BCL11A Antibody (C-term) (Cat. #AP50355PU-N) in Jurkat, Ramos, 293, NCI-H460 cell line lysates (35µg/lane). BCL11A (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Bcl-11A (BCL-11A + 11B) antibody

Bcl-11A Rabbit Aff - Purified Hu C, E, WB
25 µg / €430.00
  Acris Antibodies GmbH

Bcl-11A antibody

Bcl-11A Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Bcl-11A antibody

Western Blot analysis of BCL11A expression in transfected 293T cell line (H00053335-T01) by BCL11A MaxPab polyclonal antibody.

Lane 1: BCL11A transfected lysate(26.73 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Bcl-11A antibody

Bcl-11A Mouse Hu WB
50 µg / €370.00
  Abnova Taiwan Corp.

Bcl-11A antibody

Western Blot analysis of BCL11A expression in transfected 293T cell line (H00053335-T01) by BCL11A MaxPab polyclonal antibody.

Lane 1: BCL11A transfected lysate(26.90 KDa).
Lane 2: Non-transfected lysate. Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

Bcl-11A antibody

Western Blot analysis of BCL11A expression in transfected 293T cell line (H00053335-T01) by BCL11A MaxPab polyclonal antibody.

Lane 1: BCL11A transfected lysate(26.90 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Bcl-11A antibody

Immunoperoxidase of monoclonal antibody to BCL11A on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml] Mouse IgG2a 3D9 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Bcl-11A antibody

Human Spleen; Immunohistochemistry with Human Spleen lysate tissue at an antibody concentration of 5.0ug/ml using anti-BCL11A antibody (ARP39322_P050); BCL11A antibody - N-terminal region (ARP39322_P050) in Human Spleen cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

Bcl-11A (C-term) antibody

Human PANC1; WB Suggested Anti-BCL11A Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: PANC1 cell lysate; BCL11A antibody - C-terminal region (ARP39569_P050) in Human PANC1 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Bcl-11A antibody

ELISA: Ctip1 Antibody [21250002] Rabbit Hu E, P
50 µg / €440.00
  Novus Biologicals Inc.

Bcl-11A antibody

WB and IP: Bcl-11a Antibodies SuperNovus Pack NB100-948-Detection of Human Bcl11a on HeLa whole cell lysates using NB600-259. Bcl11a was also immunoprecipitated using NB600-258, NB600-259, NB600-261. Rabbit Aff - Purified Hu IP, WB
3 vials / €700.00
  Novus Biologicals Inc.

Bcl-11A (N-term) antibody

WB and IP: Bcl-11a Antibody [NB600-258] - Detection of Human Bcl11a on HeLa whole cell lysate using NB600-258. Bcl11a was also immunoprecipitated using affinity purified rabbit anti-Bcl11a antibodies NB600-258, NB600-259, and NB600-261. Rabbit Aff - Purified Hu IP, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Bcl-11A (transcript variant 3)

Bcl-11A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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