Bcl-2 antibody

Principal name

Bcl-2 antibody

Alternative names for Bcl-2 antibody

BCL2, Bcl-2 alpha, Apoptosis regulator Bcl-2, B-Cell CLL/lymphoma 2

SwissProt ID

O02718 (Bovin), P10415 (Human), P10417 (Mouse), P49950 (Rat), Q00709 (Chick), Q6R755 (Canfa)

Gene ID

596 (BCL2), 24224 (Bcl2), 12043

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Bov (Bovine), Mky (Monkey), Por (Porcine)

Available hosts

Rabbit, Mouse, Sheep, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunoprecipitation (IP), Flow Cytometry (F), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Neutralisation (NEUT)

Background of Bcl-2 antibody

Bcl-2 is a 26 kDa member of the family of proteins involved in regulation of programmed cell death, or apoptosis. It is expressed in a variety of both normal and neoplastic tissues and appears to be membranebound since it is detectable in crude membrane and nuclear fractions, but not in the soluble fraction of cell lysates. Overexpression of Bcl-2 can prevent apoptosis, while formation of heterodimers with Bax, another Bcl-2-related protein, inhibits Bcl-2’s ability to promote cell survival.
Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. (Ref.2) It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. (Ref.3)
Bcl-2 is a widely studied protein that has been shown to be a potent inhibitor of programmed cell death. It has been localized to the outer mitochondrial membrane, perinuclear membrane, and endoplasmic reticulum. Bcl-2 is expressed in memory and resting, or other long-lived lymphoid cells, follicular mantle cells, medullary thymocytes, and lymphomas. Germical center cells and cortical thymocytes are negative for Bcl-2. Upregulation of Bcl-2 prevents or delays apoptosis induced by a variety of stimuli, including growth factor deprivation, gamma-irradiation, glucocorticoids, and chemotherapeutic agents. During lymphoid development, expression of the Bcl-2 protein appears to be regulated in a stage-specific manner, and is thought to be a survival signal for positive selection.

General readings

1. Bartoszewski R  et al. Mangiferin has an additive effect on the apoptotic properties of hesperidin in Cyclopia sp. tea extracts. PLoS One 9:e92128 (2014). WB ; Human . 
2. Adams SM  et al. Soy isoflavones genistein and daidzein exert anti-apoptotic actions via a selective ER-mediated mechanism in neurons following HIV-1 Tat(1-86) exposure. PLoS One 7:e37540 (2012). ELISA ; Rat .
3. Fujita H  et al. Novel method for measuring active tension generation by C2C12 myotube using UV-crosslinked collagen film. Biotechnol Bioeng 106:482-9 (2010). WB ; Mouse .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Bcl-2 (61-76) antibody

Western blot analysis of extracts from mouse splenocytes using anti-Bcl-2, clone BCL/10C4. Mouse IgG1 BCL/10C4 Purified Ms, Rt F, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2 (61-76) antibody

Western blot analysis of extracts from mouse splenocytes using anti-Bcl-2, clone BCL/10C4. Mouse IgG1 BCL/10C4 Purified Ms, Rt F, ICC/IF, WB
25 µg / €210.00
  Acris Antibodies GmbH

Bcl-2 (41-54) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with Bcl-2 Antibody Cat.-No AM32832PU (Clone 8C8). Note cell membrane and cytoplasmic staining. Mouse IgG1 8C8 Purified Hu, Mky, Por C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Bcl-2 (41-54) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with Bcl-2 Antibody Cat.-No AM32832PU (Clone 8C8). Note cell membrane and cytoplasmic staining. Mouse IgG1 8C8 Purified Hu, Mky, Por C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Bcl-2 (41-54) antibody

Formalin-Fixed, Paraffin-Embedded Human tonsil stained with Bcl-2 Antibody Cat.-No AM32832PU (Clone 8C8). Note cell membrane and cytoplasmic staining. Mouse IgG1 8C8 Purified Hu, Mky, Por C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Bcl-2 antibody

Western blot analysis of extracts of various cell lines using BCL2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2 antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-BCL2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA803003) Mouse IgG1 OTI2E5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Bcl-2 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-BCL2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA806591) Mouse IgG2b OTI9D3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Bcl-2 (1-211) antibody

Immunofluorescence of HeLa cells stained with Hoechst 3342 (Blue) for nucleus staining and with monoclonal anti-human Bcl-2 antibody (1:500) with Texas Red (Red). Mouse IgG2b AT1B5 Purified Hu, Ms E, F, ICC/IF, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

Bcl-2 (1-211) antibody

Immunofluorescence of HeLa cells stained with Hoechst 3342 (Blue) for nucleus staining and with monoclonal anti-human Bcl-2 antibody (1:500) with Texas Red (Red). Mouse IgG2b AT1B5 Purified Hu, Ms E, F, ICC/IF, WB
50 µl / €230.00
  Acris Antibodies GmbH

Bcl-2 (N-term) antibody

Representative pictures of Bcl2 expression in HEK293 cells, visualized with clonal rabbit anti-Bcl2 monospecific antibody (clone P22-A). Primary antibody dilution - 1:200.  Rabbit IgG P22-A Aff - Purified Hu, Ms, Rt C, E, ICC/IF, IP, P, WB
0.1 ml / €460.00
  DB Biotech, spol. s r.o.

Sample sizes available

Bcl-2 (N-term) antibody

Representative pictures of Bcl2 expression in HEK293 cells, visualized with clonal rabbit anti-Bcl2 monospecific antibody (clone P22-A). Primary antibody dilution - 1:200.  Rabbit IgG P22-A Aff - Purified Hu, Ms, Rt C, E, ICC/IF, IP, P, WB
50 µl / €310.00
  DB Biotech, spol. s r.o.

Sample sizes available

Bcl-2 (41-54) antibody

Formalin-Paraffin non-Hodgkin's lymphoma stained with Bcl-2 Antibody (Clone 100/D5) Cat.-No AM33245PU. Note nuclear membrane & cytoplasmic staining. Mouse IgG1 100/D5 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Bcl-2 (41-54) antibody

Formalin-Paraffin non-Hodgkin's lymphoma stained with Bcl-2 Antibody (Clone 100/D5) Cat.-No AM33245PU. Note nuclear membrane & cytoplasmic staining. Mouse IgG1 100/D5 Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Bcl-2 (41-54) antibody

Formalin-Paraffin non-Hodgkin's lymphoma stained with Bcl-2 Antibody (Clone 100/D5) Cat.-No AM33245PU. Note nuclear membrane & cytoplasmic staining. Mouse IgG1 100/D5 Purified Hu C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Bcl-2 antibody

Formalin-Paraffin non-Hodgkin's lymphoma stained with Bcl-2 Antibody Cat.-No AM33344PU (Clone 124). Note nuclear membrane & cytoplasmic staining. Mouse IgG1 124 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Bcl-2 antibody

Formalin-Paraffin non-Hodgkin's lymphoma stained with Bcl-2 Antibody Cat.-No AM33344PU (Clone 124). Note nuclear membrane & cytoplasmic staining. Mouse IgG1 124 Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Bcl-2 antibody

Formalin-Paraffin non-Hodgkin's lymphoma stained with Bcl-2 Antibody Cat.-No AM33344PU (Clone 124). Note nuclear membrane & cytoplasmic staining. Mouse IgG1 124 Purified Hu C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Bcl-2 antibody

Formalin-paraffin non-Hodgkin's lymphoma stained with Bcl-2 Antibody Cat.-No AM50163PU (Clone SPM117). Note nuclear membrane & cytoplasmic staining. Mouse IgG1 SPM117 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Bcl-2 antibody

Formalin-paraffin non-Hodgkin's lymphoma stained with Bcl-2 Antibody Cat.-No AM50163PU (Clone SPM117). Note nuclear membrane & cytoplasmic staining. Mouse IgG1 SPM117 Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

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