Bcl-2-like 1 antibody

Principal name

Bcl-2-like 1 antibody

Alternative names for Bcl-2-like 1 antibody

Bcl2-L-1, BCL2L1, BCL2L, BCLX, Bcl-x, bcl-xL, bcl-xS, Bcl-2-like protein 1

SwissProt ID

O77737 (Pig), P53563 (Rat), Q07816 (Chick), Q07817 (Human), Q07817-1, Q64373 (Mouse)

Gene ID

598 (BCL2L1), 12048 (Bcl2l1), 24888

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit), Mky (Monkey), Fe (Feline), Sh (Sheep), Hst (Hamster)

Available hosts

Rabbit, Mouse, Sheep

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Frozen Sections (C), Immunoprecipitation (IP)

Background of Bcl-2-like 1 antibody

bcl-x is a bcl-2-related gene that can function as a regulator of programmed cell death (apoptosis) independent of bcl-2. Alternative splicing results in two distinct bcl-x mRNAs. The larger mRNA gives rise to a protein product, bcl-xl, which is similar in size and predicted structure to bcl-2 (1). The smaller mRNA gives rise to bcl-xS. bcl-x immunoreactivity has been detected in a wide variety of cell types and the protein is typically present in the cytosol in association with the mitochondrial periphery, a property shared with bcl-2 however membrane bound forms of bcl-x have been demonstrated in thymocytes (2-4). Following the induction of apoptosis all of the bcl-x protein shifts to the membrane form (2). Of the two isoforms of bcl-x, the long (bcl-xl) is the most abundant mRNA species expressed in embryonic and adult tissues and most likely differs from bcl-2 in its regulatory activity on cell differentiation through controlled tissue specific expression (1,3). Like its homolog bcl-2, bcl-x undergoes phosphorylation, a modification that requires that a specific 60 amino acid loop region be intact, which in turn appears to regulate activity (5,6). Structurally, based on 3D-structure analysis, bcl-x forms pH sensitive cation-selective ion channels in membranes a property shared with the pore forming domains of several bacterial toxins (7). Bcl-xl has been shown to modify the cell’s response to oxidants, to participate in resistance to chemotherapeutic agents and radiation, and to play a key role in the development of the developing CNS (8-10).

General readings

Bachelor,M.A. et al., (2004) J. Biol. Chem. 279 (41), 42658-42668

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Bcl-2-like 1 antibody

Sample (30 ug of whole cell lysate). . A:NIH-3T3. 12% SDS PAGE. . TA308852 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 1 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-BCL-XL mouse monoclonal antibody. (TA500097) Mouse IgG2a OTI4A9 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Bcl-2-like 1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-BCL2L1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506188) Mouse IgG1 OTI2D1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Bcl-2-like 1 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between BCL2L1 and BAX. HeLa cells were stained with anti-BCL2L1 rabbit purified polyclonal 1:1200 and anti-BAX mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Bcl-2-like 1 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between BID and BCL2L1. HeLa cells were stained with anti-BID rabbit purified polyclonal 1:1200 and anti-BCL2L1 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse IgG1 3E2-2A5 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Bcl-2-like 1 antibody

Human Hodgkin’s lymphoma stained with Anti-Bcl-xL Mouse 7D9/SPM519 Purified Hu, Ms P
0.5 ml / €360.00
  Acris Antibodies GmbH

Bcl-2-like 1 antibody

Human Hodgkin’s lymphoma stained with Anti-Bcl-xL Mouse 7D9/SPM519 Purified Hu, Ms P
1 ml / €500.00
  Acris Antibodies GmbH

Bcl-2-like 1 antibody

Human Hodgkin’s lymphoma stained with Anti-Bcl-xL Mouse 7D9/SPM519 Purified Hu, Ms P
0.1 ml / €200.00
  Acris Antibodies GmbH

Bcl-2-like 1 (1-50) antibody

Western blot analysis of Bcl-X in Jurkat lysate using Bcl-X Antibody Cat.-No AP32834PU (Clone BX006). Mouse IgG2a BX006 Purified Hu, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Bcl-2-like 1 (1-50) antibody

Western blot analysis of Bcl-X in Jurkat lysate using Bcl-X Antibody Cat.-No AP32834PU (Clone BX006). Mouse IgG2a BX006 Purified Hu, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Bcl-2-like 1 (1-50) antibody

Western blot analysis of Bcl-X in Jurkat lysate using Bcl-X Antibody Cat.-No AP32834PU (Clone BX006). Mouse IgG2a BX006 Purified Hu, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Bcl-2-like 1 antibody

Formalin-Paraffin Hodgkin's lymphoma stained with Bcl-X Antibody Cat.-No AM33365PU (Clone 2H12). Note cytoplasmic and membrane staining. Mouse IgG2a 2H12 Purified Hu, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Bcl-2-like 1 antibody

Formalin-Paraffin Hodgkin's lymphoma stained with Bcl-X Antibody Cat.-No AM33365PU (Clone 2H12). Note cytoplasmic and membrane staining. Mouse IgG2a 2H12 Purified Hu, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Bcl-2-like 1 antibody

Formalin-Paraffin Hodgkin's lymphoma stained with Bcl-X Antibody Cat.-No AM33365PU (Clone 2H12). Note cytoplasmic and membrane staining. Mouse IgG2a 2H12 Purified Hu, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Bcl-2-like 1 antibody

Formalin-paraffin Hodgkin's lymphoma stained with Bcl-x Antibody Cat.-No AM50165PU (Clone SPM165). Note cytoplasmic and membrane staining. Mouse IgG2a SPM165 Purified Hu, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Bcl-2-like 1 antibody

Formalin-paraffin Hodgkin's lymphoma stained with Bcl-x Antibody Cat.-No AM50165PU (Clone SPM165). Note cytoplasmic and membrane staining. Mouse IgG2a SPM165 Purified Hu, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Bcl-2-like 1 antibody

Formalin-paraffin Hodgkin's lymphoma stained with Bcl-x Antibody Cat.-No AM50165PU (Clone SPM165). Note cytoplasmic and membrane staining. Mouse IgG2a SPM165 Purified Hu, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Bcl-2-like 1 antibody

Formalin-Paraffin Hodgkin's lymphoma stained with Bcl-X Antibody Cat.-No AM50202PU (Clone BX006 + 2H12). Note cytoplasmic and membrane staining. Mouse IgG2a BX006 + 2H12 Purified Hu, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Bcl-2-like 1 antibody

Formalin-Paraffin Hodgkin's lymphoma stained with Bcl-X Antibody Cat.-No AM50202PU (Clone BX006 + 2H12). Note cytoplasmic and membrane staining. Mouse IgG2a BX006 + 2H12 Purified Hu, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Bcl-2-like 1 antibody

Formalin-Paraffin Hodgkin's lymphoma stained with Bcl-X Antibody Cat.-No AM50202PU (Clone BX006 + 2H12). Note cytoplasmic and membrane staining. Mouse IgG2a BX006 + 2H12 Purified Hu, Ms, Por, Rt C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

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