Bcl-2-like 10 antibody

Principal name

Bcl-2-like 10 antibody

Alternative names for Bcl-2-like 10 antibody

Bcl2-L-10, BCL2L10, BCLB, Bcl-B, NrH, Apoptosis regulator Bcl-B, Anti-apoptotic protein NrH

SwissProt ID

Q9HD36 (Human), Q9Z0F3 (Mouse)

Gene ID

10017 (BCL2L10), 12049 (Bcl2l10)

Available reactivities

Hu (Human)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection))

Background of Bcl-2-like 10 antibody

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq]

General readings

Kang Y, Lee DC, et al. (2007). Biochem Biophys Res Commun. 359(1):76-82.Guillemin Y, Lalle P, et al. (2009). J Mol Med (Berl). 87(9):923-40.

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