Bcl-2-like 11 antibody

Principal name

Bcl-2-like 11 antibody

Alternative names for Bcl-2-like 11 antibody

Bcl2-L-11, BCL2L11, BIM, BimEL, BimL, BimS, Bcl2-interacting mediator of cell death

SwissProt ID

O43521 (Human), O54918 (Mouse), O88498 (Rat)

Gene ID

10018 (BCL2L11), 12125 (Bcl2l11), 64547

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Goat, Rat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Bcl-2-like 11 antibody

Bim/Bod is a pro-apoptotic protein belonging to the BH3-only group of Bcl-2 family members including Bad, Bid, Bik, Hrk and Noxa that contain a BH3 domain but lack other conserved BH1 or BH2 domains. Bim induces apoptosis by binding to and antagonizing anti-apoptotic members of the Bcl-2 family. Interactions have been observed with Bcl-2, Bcl-xL, Mcl-1, Bcl-w, Bfl-1 and BHRF-1. Bim functions in regulating apoptosis associated with thymocyte negative selection and following growth factor withdrawal, during which Bim expression is elevated. Three major isoforms of Bim are generated by altertive splicing: BimEL, BimL and BimS. The shortest form, BimS, is the most cytotoxic and is generally only transiently expressed during apoptosis. The BimEL and BimL isoforms may be sequestered to the dynein motor complex through an interaction with the dynein light chain and released from this complex during apoptosis. Apoptotic activity of these longer isoforms may be regulated by phosphorylation. Environmental stress triggers Bim phosphorylation by JNK and results in its dissociation from the dynein complex and increased apoptotic activity.

General readings

1. Marani M, Tenev T, Hancock D, Downward J, Lemoine NR.
Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.
Mol Cell Biol. 2002 Jun;22(11):3577-89. PMID: 11997495­¬«1

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Bcl-2-like 11 (Center) antibody

Formalin-fixed and paraffin-embedded human colon carcinoma reacted with BCL2L11 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu E, F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Bcl-2-like 11 antibody

Western blot analysis of Bim in K562 cell lysate with Bim EL antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 BOD antibody

Human placenta stained with Anti-Bim antibody Rabbit Purified Hu, Ms, Rt P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

Bcl-2-like 11 BOD antibody

Human placenta stained with Anti-Bim antibody Rabbit Purified Hu, Ms, Rt P, WB
1 ml / €450.00
  Acris Antibodies GmbH

Bcl-2-like 11 BOD antibody

Human placenta stained with Anti-Bim antibody Rabbit Purified Hu, Ms, Rt P, WB
0.1 ml / €180.00
  Acris Antibodies GmbH

Bcl-2-like 11 (C-term) antibody

TA302948 staining (0.5µg/ml) of K562lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Western blot analysis of Bim in K562 (K) and A549 (A) whole cell lysates with Bim antibody at 1 ug/ml. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 (Center) antibody

Western blot analysis of Bim in K562 cell lysates with Bim antibody (IN2) at (A) 2.5 and (B) 5 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using BIM (phospho-Ser69/65) antibody. Rabbit IgG Purified Hu, Ms, Rt P
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 (2-198) antibody

Western blot analysis of (A) 5 and (B) 25 ng of Bim recombinant protein with Bim antibody at 1 ug/mL. Mouse IgG 1C2C8 Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 (2-198) antibody

Western blot analysis of 5 ng of Bim recombinant protein with Bim antibody at 1 ug/mL. Mouse IgG 1C2H4 Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Western blot analysis on COS7 cell lysate using BIM Antibody Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Western blot analysis of extracts from COS7, using Bim antibody (#TA326096).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Western blot analysis of Bim in K562 (Left) and A549 (Right) whole cell lysates using a 1:1000 dilution of the antibody Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Western blot analysis of Bim Bod in A549 cell lysates using 10ug of the antibody Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Western blot analysis of extracts of mouse eye tissue, using BIM antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using Phospho-BCL2L11-S69 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Western blot analysis of BIM expression in COS7 cells Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Bcl-2-like 11 Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 pSer69/65 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using BIM pSer69 antibody AP02527PU Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
0.1 ml / €320.00
  Acris Antibodies GmbH

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