Bcl-2-like 11 antibody

Principal name

Bcl-2-like 11 antibody

Alternative names for Bcl-2-like 11 antibody

Bcl2-L-11, BCL2L11, BIM, BimEL, BimL, BimS, Bcl2-interacting mediator of cell death

SwissProt ID

O43521 (Human), O54918 (Mouse), O88498 (Rat)

Gene ID

10018 (BCL2L11), 12125 (Bcl2l11)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Goat, Rat, Hamster

Available applications

Paraffin Sections (P), Functional assay (FN), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C), Flow Cytometry (F)

Background of Bcl-2-like 11 antibody

Apoptosis or programmed cell death is a physiological cellular process characterized by cell shrinkage, membrane blebbing, DNA fragmentation, and release of Cytochrome C from the mitochondria. It is utilized by the organism to get rid of unwanted cells, which is critical for normal development and homeostasis of an organism. Disregulation of normal apoptosis process have been implicated in a variety of diseases, including cancer, autoimmune diseases, viral infections, etc. Programmed cell death occurs through complex cascades of cell signaling in which Bcl-2 family members, among others, play an important role.The Bcl-2 family of proteins regulate apoptosis as well as execute death signals at the mitochondrion. Members of this family include both pro- and anti-apoptotic proteins that hare homology sequences called Bcl-2 Homology domains (BH1-4) which mediate dimmer formation. The BH3 proteins, such as BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region, which is required for their apoptotic function. They may trigger release of death-inducing molecules such as Cytochrome C, Smac, and endonuclease G. Anti-apoptotic family members, including Bcl-2 and Bcl-XL, play inhibitory roles. Bcl-2 family proteins may form homodimers or heterodimers between pro- and anti-apoptotic members, the ratios of which determine the cell fate.

General readings

1. Marani M, Tenev T, Hancock D, Downward J, Lemoine NR.
Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.
Mol Cell Biol. 2002 Jun;22(11):3577-89. PMID: 11997495­¬«1

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Bcl-2-like 11 (Center) antibody

Formalin-fixed and paraffin-embedded human colon carcinoma reacted with BCL2L11 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu E, F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Bcl-2-like 11 antibody

Western blot analysis of Bim in K562 cell lysate with Bim EL antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 BOD antibody

Human placenta stained with Anti-Bim antibody Rabbit Purified Hu, Ms, Rt P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

Bcl-2-like 11 BOD antibody

Human placenta stained with Anti-Bim antibody Rabbit Purified Hu, Ms, Rt P, WB
1 ml / €440.00
  Acris Antibodies GmbH

Bcl-2-like 11 BOD antibody

Human placenta stained with Anti-Bim antibody Rabbit Purified Hu, Ms, Rt P, WB
0.1 ml / €180.00
  Acris Antibodies GmbH

Bcl-2-like 11 (C-term) antibody

TA302948 staining (0.5µg/ml) of K562lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Western blot analysis of Bim in K562 (K) and A549 (A) whole cell lysates with Bim antibody at 1 ug/ml. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 (Center) antibody

Western blot analysis of Bim in K562 cell lysates with Bim antibody (IN2) at (A) 2.5 and (B) 5 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 (2-198) antibody

Western blot analysis of (A) 5 and (B) 25 ng of Bim recombinant protein with Bim antibody at 1 ug/mL. Mouse IgG 1C2C8 Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 (2-198) antibody

Western blot analysis of 5 ng of Bim recombinant protein with Bim antibody at 1 ug/mL. Mouse IgG 1C2H4 Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Western blot analysis on COS7 cell lysate using BIM Antibody Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Western blot analysis of extracts from COS7, using Bim antibody (#TA326096).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Western blot analysis of Bim in K562 (Left) and A549 (Right) whole cell lysates using a 1:1000 dilution of the antibody Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Western blot analysis of Bim Bod in A549 cell lysates using 10ug of the antibody Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Western blot analysis of extracts of mouse eye tissue, using BIM antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 antibody

Western blot analysis of BIM expression in COS7 cells Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 11 pSer69/65 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using BIM pSer69 antibody AP02527PU Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
0.1 ml / €320.00
  Acris Antibodies GmbH

Bcl-2-like 11 pSer69/65 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using BIM pSer69 antibody AP02527PU Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
50 µl / €240.00
  Acris Antibodies GmbH

Bcl-2-like 11 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using BIM antibody. Rabbit Aff - Purified Hu, Ms P, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

Bcl-2-like 11 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using BIM antibody. Rabbit Aff - Purified Hu, Ms P, WB
50 µl / €230.00
  Acris Antibodies GmbH

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