Bcl-2-like 7 antibody

Principal name

Bcl-2-like 7 antibody

Alternative names for Bcl-2-like 7 antibody

BAK1, BAK, BCL2L7, Bcl2-L-7, CDN1, Bcl-2 homologous antagonist/killer, Apoptosis regulator BAK, Bcl-2-like protein 7, cell death inhibitor 1

SwissProt ID

O08734 (Mouse), Q16611 (Human)

Gene ID

578 (BAK1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Hst (Hamster), Por (Porcine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of Bcl-2-like 7 antibody

Apoptosis or programmed cell death is a physiological cellular process characterized by cell shrinkage, membrane blebbing, DNA fragmentation, and release of Cytochrome C from the mitochondria. It is utilized by the organism to get rid of unwanted cells, which is critical for normal development and homeostasis of an organism. Disregulation of normal apoptosis process have been implicated in a variety of diseases, including cancer, autoimmune diseases, viral infections, etc. Programmed cell death occurs through complex cascades of cell signaling in which Bcl-2 family members, among others, play an important role.The Bcl-2 family of proteins regulate apoptosis as well as execute death signals at the mitochondrion. Bak or Bcl-2 homologous antagonist is a member of the Bcl-2 family of holologous proteins which function in the regulation of apoptosis. The Bcl-2 related proteins interact with one another through the formation of homo and heterodimers. The susceptibility of cells to apoptotic stimuli is thought to be controlled by the relativeratios of the different Bcl-2 family proteins. Bak is a 211 aa protein (24kD) which has been demonstrated to accelerate the rate of apoptosis in growth factor deprived murine lymphoid, neuronal and fibroblastic cell lines. Bak has been localized by immunohistochemistry to the cytosol of cells and stains in a punctate pattern characteristic of other bcl-2 family proteins, which have been localized to intracellular organelles. Immunohistochemical studies further show that Bak expression is widespread, and may show some correlation with the apoptopic state of cells.

General readings

Birgit Kemmerling, et al. (2008) Plant Signal Behav, 3(2): 116–118.
Libo Shan, et al. (2008) Cell Host Microbe, 4(1): 17–27.
Xu-Bao Shi, et al. (2007) Proc Natl Acad Sci U S A, 104(50): 19983–19988.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Bcl-2-like 7 (1-14) antibody

Human Lung, respiratory epithelium: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Bcl-2-like 7 (N-term) antibody

TA302647 staining (0.5µg/ml) of A431 lysate (RIPA buffer, 30µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Hu, Ms, Por, Rt E, WB
20 µg / €200.00
  Acris Antibodies GmbH

Bcl-2-like 7 (N-term) antibody

TA302647 staining (0.5µg/ml) of A431 lysate (RIPA buffer, 30µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Hu, Ms, Por, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 7 (N-term) antibody

Western blot analysis of Bak in L1210 cell lysates with Bak antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 7 antibody

Western blot analysis of extracts from 293 cells, using Bak antibody (#TA311844).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 7 antibody

Predicted band size: 23kDa. Positive control: Hela, A431, 293T and Jurkat cell lysate. Recommended dilution: 1/1000-5000. (Gel: 12%SDS-PAGE Lane1-4: Hela, A431, 293T and Jurkat cell lysate Lysates: 40 ug per lane Primary antibody: 1/900 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 5 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 7 antibody

Western blot analysis of extracts of MCF7 cell lines, using BAK1 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 7 antibody

WB Suggested Anti-BAK1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Muscle Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 7 antibody

Western blot analysis on 293 cell lysate using Bak Antibody Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Bcl-2-like 7 antibody

Immunofluorescence of human HeLa cells stained with Hoechst 3342 (Blue) for nucleus staining and monoclonal anti-human BAK1 antibody (1:500) with Texas Red (Red). Mouse IgG2a AT8B4 Purified Hu, Ms E, ICC/IF, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

Bcl-2-like 7 antibody

Immunofluorescence of human HeLa cells stained with Hoechst 3342 (Blue) for nucleus staining and monoclonal anti-human BAK1 antibody (1:500) with Texas Red (Red). Mouse IgG2a AT8B4 Purified Hu, Ms E, ICC/IF, WB
50 µl / €230.00
  Acris Antibodies GmbH

Bcl-2-like 7 antibody

Immunohistochemistry (IHC) analyzes of Bak1/2 antibody (Cat.-No.: AP06026PU-N) in paraffin-embedded human skeletal muscle tissue. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Bcl-2-like 7 (BH3 Domain) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Bcl-2-like 7 (N-term) antibody

Human Skeletal Muscle (formalin-fixed, paraffin-embedded) stained with BAK1 antibody AP22701PU-N at 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hst, Hu, Ms P
0.25 ml / €470.00
  Acris Antibodies GmbH

Bcl-2-like 7 Control Peptide

Bcl-2-like 7
50 µg / €160.00
  Acris Antibodies GmbH

Bcl-2-like 7 antibody

Western Blot analysis of BAK1 expression in transfected 293T cell line (H00000578-T02) by BAK1 MaxPab polyclonal antibody.

Lane 1: BAK1 transfected lysate(23.40 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Bcl-2-like 7 antibody

Bcl-2-like 7 Mouse IgM 1E4 Ascites Hu E
0.2 ml / €370.00
  Abnova Taiwan Corp.

Bcl-2-like 7 antibody

Formalin-fixed paraffin-embedded human tissue for Bak expression using BAK1 polyclonal antibody ( Cat # PAB0333 ) at 1 : 2000. A. Ductal breast carcinoma. B. Lymphocyte infiltration in soft tissue adjacent to colon carcinoma. Hematoxylin-eosin counterstain. Rabbit Hu IP, P
50 µl / €390.00
  Abnova Taiwan Corp.

Bcl-2-like 7 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the BAK1 polyclonal antibody ( Cat # PAB2439 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Bcl-2-like 7 antibody

BAK1 polyclonal antibody ( Cat # PAB6121 ) staining ( 0.5 µg/ml ) of A-431 lysate ( RIPA buffer, 30 µg total protein per lane ) . Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

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