Beclin-1 antibody

Principal name

Beclin-1 antibody

Alternative names for Beclin-1 antibody

BECN1, GT197, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197

SwissProt ID

O88597 (Mouse), Q14457 (Human), Q4A1L4 (Bovin), Q4A1L5 (Pig), Q5ZKS6 (Chick), Q91XJ1 (Rat)

Gene ID

8678 (BECN1)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Chk (Chicken), Eq (Equine), Mky (Monkey), Por (Porcine), Rt (Rat), Xen (Xenopus), Can (Canine), Prim (Primate), Hst (Hamster)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of Beclin-1 antibody

Bellini-1 (beclin 1, autophagy related) is a protein that in humans is encoded by the BECN1 gene, also known as BECN1, ATG6, VPS30, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, autophagy-related gene (Atg) 6. Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, are required for the initiation of the formation of the autophagosome in autophagy. Human beclin encodes a novel 450-amino acid protein containing a coiled-coil region, within which it has limited homology to myosin-like proteins. Northern blot analysis of mouse and adult human tissues revealed widespread beclin expression. A 2.2-kb transcript was present at highest levels in human skeletal muscle and at detectable levels in all tissues examined. In some tissues, additional 1.7- and 1.4-kb transcripts were observed, suggesting the presence of alternatively spliced transcripts. Immunoperoxidase staining of human hippocampus and frontal cortex sections revealed beclin immunoreactivity in many neurons throughout these regions, as well as in some glial cells. Beclin protects against infection by a neurovirulent strain of Sindbis virus that is known to overcome the protective effects of Bcl2. Liang et al.  showed that beclin reduced Sindbis virus replication in mouse brain and reduced Sindbis virus-induced cell death in mouse brain.

General readings

1. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 2005; 115:911-9.
Tsao T-S, Lodish HF, and Fruebis J. ACRP30, a new hormone controlling fat and glucose metabolism. Euro. J. Pharmacol. 2002; 440:213-21.
2. Wong GW, Wang J, Hug C, et al. A family of Acrp30/ adiponectin structural and functional paralogs. Proc. Natl. Acad. Sci. USA 2004; 101:10302-7.
3. Shapiro L and Scherer PE. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr. Biol. 1998; 8:335-8.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Beclin-1 antibody

Anti-BECN1 mouse monoclonal antibody (TA502617) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY BECN1(RC201629). Mouse IgG2a OTI4A10 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Beclin-1 antibody

Detection of Beclin in mouse liver tissue lysate (50 ug). ECL detection at 1 minute Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Beclin-1 antibody

Western Blot: Beclin 1 Antibody [TA336561] - Beclin 1 antibody image from verified customer review. Rabbit Purified Can, Hu, Ms, Por, Prim C, ICC/IF, P, WB
50 µl / €325.00
  OriGene Technologies, Inc.

Beclin-1 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-BECN1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502517) Mouse IgG2a OTI3H8 Purified Hu, Mky, Rt F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Beclin-1 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-BECN1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502527) Mouse IgG1 OTI3F3 Purified Hu, Mky, Rt F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Beclin-1 antibody

Immunofluorescent staining of HeLa cells using anti-BECN1 mouse monoclonal antibody (TA502615). Mouse IgG2a OTI2C5 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Beclin-1 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-BECN1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502616) Mouse IgG1 OTI3C3 Purified Can, Hu, Mky, Rt F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Beclin-1 antibody

Anti-BECN1 mouse monoclonal antibody (TA502618) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY BECN1(RC201629). Mouse IgG2a OTI2D4 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Beclin-1 antibody

Anti-BECN1 mouse monoclonal antibody (TA502619) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY BECN1(RC201629). Mouse IgG1 OTI2A7 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Beclin-1 antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-BECN1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502643) Mouse IgG2a OTI1F1 Purified Can, Hu, Rt F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Beclin-1 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-BECN1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502674) Mouse IgG1 OTI1E1 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Beclin-1 antibody

Immunohistochemical analysis of paraffin-embedded breast cancer tissues (left) and liver cancer tissues (right) using BECN1 antibody Cat.-No AM06595SU-N with DAB staining. Mouse IgG1 2A4 Ascites Hu E, F, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

Beclin-1 (C-term) antibody

Immunohistochemistry staining of human heart (Formalin-fixed, Paraffin-embedded tissue after heat-induced antigen retrieval) using Beclin-1 antibody Cat.-No. AP22863PU-N (C-term). Rabbit Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Beclin-1 (N-term) antibody

Human Lung, Respiratory Epithelium (formalin-fixed, paraffin-embedded) stained with BECN1 antibody AP22864PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Beclin-1 antibody

Detection of Beclin 1 in liver lysates. Lane 1 mouse liver, Lane 2 human liver Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Beclin-1 (C-term) antibody

Western blot analysis of Beclin-1 in A431 cell lysate with Beclin-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Beclin-1 (N-term) antibody

Western blot analysis of Beclin-1 in 293 cell lysate with Beclin-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Beclin-1 antibody

Gel: 8%SDS-PAGE,Lysate: 40 µg,Lane 1-2: 293T cells, Raji cells,Primary antibody:BECN1 Antibody at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Beclin-1 antibody

Predicted cell location: Cell membrane, Cytoplasm . Positive control: Human brain and tonsil tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human brain and tonsil tissue using BECN1 antibody at dilution 1/15, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Beclin-1 antibody

Western Blot: Beclin 1 Antibody (1B7) [TA336696] - Analysis of Beclin 1 in 1. NIH3T3 lysate and 2. Cos7 cell lysate. Mouse IgG1 1B7 Purified Bov, Chk, Eq, Hu, Ms, Rt C, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

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